International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.




Aude Magerus-Chatinet

Research scientist

Doctor AudeMagerus-Chatinetwas born in Reims (Champagne, France). She earned a research professorship from the Paris Descartes University, a PhD degree from the PARIS VI University, Master’s Degree in Immunology,and a bachelor’s degree in biochemistry from the University of Reims.  She is aresearch scientist at the Imagine Institute in Paris (France). Her background includes 18 years of experience as researcher in Immunology.  She first studies the regulation of the SDF1 chemokine’s expression at the Pasteur Institute of Paris. She worked 5 years at the Cochin Institute on the role of dendritic cells in the mucosal transmission of the HIV-1. Then she moved to Necker’s hospital for Sick childrento work on the genetic factors involved in the pediatric autoimmune diseases outcome.

She is an active member of the directive board of the French Society of Immunology and acted as a reviewer for PlosOne, Haematologica and Journal of ImmunologyResearch.

Current Research

  • Search for new genes involved in pediatric autoimmune diseases
  • Immune check-point control
  • T cells homeostasis

Interested topics

  • Pediatric autoimmune diseases
  • ALPS
  • Dendritic cells
  • 2009 – Recipient, Award from Immunotherapy, LFB society.
  • 2010 - Recipient, Award from Immunotherapy, LFB society.
  • Dr P. Arkwright ; St Mary'sHospital, Manchester, Department of Child Health, UK.
  • Dr J. Pachlopnick Schmid ; PediatricImmunology and Children'sResearch Center, UniversityChildren'sHospital Zurich, Zurich, Switzerland.
  • Pr S. Ehl ; Center for ChronicImmunodeficiency, UniversityMedical Center Freiburg, University of Freiburg, Freiburg, Germany; Center for Paediatrics and Adolescent Medicine, UniversityMedical Center, University of Freiburg, Freiburg, Germany.
  • Dr M. Madkaikar- Dr K. Gosh ; Department of PediatricImmunology and LeukocyteBiology, National Institute of Immunohaematology (ICMR), Mumbai, India
  • Dr I. Mabrouk ; Research Unit of MolecularBiologyLeukemia and Lymphomas, Faculty of Medicine of Sousse, Sousse, Tunisia.
  • 7 congress oral presentations
  • 27 peer-review publications
  1. Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome.Vavassori S, Galson JD, Trück J, van den Berg A, Tamminga RYJ, Magerus-Chatinet A, Pellé O, Camenisch Gross U, Marques Maggio E, Prader S, Opitz L, Nüesch U, Mauracher A, Volkmer B, Speer O, Suda L, Röthlisberger B, Zimmermann DR, Müller R, Diepstra A, Visser L, Haralambieva E, Neven B, Rieux-Laucat F, PachlopnikSchmid J.
    Blood Adv. 2017 Jun 22;1(15):1101-1106.
  2. In Vitro Evaluation of the Apoptosis Function in Human Activated T Cells.
    Magerus-Chatinet A, Rieux-Laucat F.
    Methods Mol Biol. 2017;1557:33-40.
  3. Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome. Christian Klemann, Myrian Esquivel, AudeMagerus-Chatinet, MyriamRicarda Lorenz, Ilka Fuchs, Nathalie Neveux, Martin Castelle, Jan Rohr, Claudia Bettoni da Cunha, Martin Ebinger, Robin Kobbe, Bernhard Kremens, Florian Kollert, EleonoraGambineri, Kai Lehmberg, Markus Seidel, Kathrin Siepermann, Thomas Voelker, Volker Schuster, SiguneGoldacker, Klaus Schwarz, CarstenSpeckmann, Capucine Picard, Alain Fischer, Frederic Rieux-Laucat, Stephan Ehl, and Anne Rensing-Ehl, BenedicteNeven.
    Haematologica 2017 Feb;102(2):e52-e56.
  4. Defective anti-polysaccharide response and splenic marginal zone disorganization in ALPS patients. Neven B, Bruneau J, Stolzenberg MC, Meyts I, Magerus-Chatinet A, Moens L, Lanzarotti N, Weller S, Amiranoff D, Florkin B, Bader-Meunier B, Leverger G, Ferster A, Chantrain C, Blanche S, Picard C, Molina TJ, Brousse N, Durandy A, Rizzi M, Bossuyt X, Fischer A, Rieux-Laucat F.
    Blood. 2014 Sep 4;124(10):1597-609.
  5. Somatic loss of heterozygosity, but not haploinsufficiency alone, leads to full-blown autoimmune lymphoproliferative syndrome in 1 of 12 family members with FAS start codon mutation. Hauck F, Magerus-Chatinet A, Vicca S, Rensing-Ehl A, Roesen-Wolff A, Roesler J, Rieux-Laucat F. ClinImmunol. 2013 Apr; 147(1): 61-8.
  6. Diagnosis of autoimmune lymphoproliferative syndrome caused by FAS deficiency in adults. Lambotte O, Neven B, Galicier L, Magerus-Chatinet A, Schleinitz N, Hermine O, Meyts I, Picard C, Godeau B, Fischer A, Rieux-Laucat F.
    Haematologica. 2013 Mar; 98(3): 389-92.
  7. Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation. Magerus-Chatinet A, Stolzenberg MC, Lanzarotti N, Neven B, Daussy C, Picard C, Neveux N, Desai M, Rao M, Ghosh K, Madkaikar M, Fischer A, Rieux-Laucat F.
    J Allergy ClinImmunol. 2013 Feb; 131(2): 486-90.
  8. A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation. Neven B, Magerus-Chatinet A, Florkin B, Gobert D, Lambotte O, De Somer L, Lanzarotti N, Stolzenberg MC, Bader-Meunier B, Aladjidi N, Chantrain C, Bertrand Y, Jeziorski E, Leverger G, Michel G, Suarez F, Oksenhendler E, Hermine O, Blanche S, Picard C, Fischer A, Rieux-Laucat F Blood. 2011 Nov 3; 118 (18):4798-807.
  9. Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation Magerus-Chatinet A, Neven B, Stolzenberg MC, Daussy C, Arkwright PD,Lanzarotti N, Schaffner C, Cluet-Dennetiere S, Haerynck F, Michel G, Bole-Feysot C, Zarhrate M, Radford-Weiss I, Romana SP, Picard C, Fischer A and Rieux-Laucat F.J Clin Invest. 2011 Jan 4; 121(1):106-12. 
  10. FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function. Magerus-Chatinet A, Stolzenberg MC, Loffredo MS, Neven B, Schaffner C, Ducrot N, Arkwright PD, Bader-Meunier B, Barbot J, Blanche S, Casanova JL, Debré M, Ferster A, Fieschi C, Florkin B, Galambrun C, Hermine O, Lambotte O, Solary E, Thomas C, Le Deist F, Picard C, Fischer A, Rieux-Laucat F. Blood. 2009 Mar 26; 113(13):3027-30.