International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.




ShijunJ. Zheng



Dr. Shijun J Zheng is a Professor of Microbiology and Immunology in the college of Veterinary Medicine at China Agricultural University. He completed a DVM in the College of Veterinary Medicine at China Agricultural University in 1987 and a PhD in the Dept of Veterinary and Animal Sciences at the University of Massachusetts Amherst in 2000. He underwent postdoctoral training at the University of Pennsylvania School of Medicine (2000-2005) working on mechanism of autoimmune diseases and microbial pathogenesis. He then returned to China as a specially recruited talent and worked as a Professor of Microbiology and Immunology in the College of Veterinary Medicine and as a Principal Investigator in the State Key Laboratory of Agriobiotechnology at China Agricultural University.


He obtained a State Outstanding Talented Youth Grant from National Nature Science Foundation of China (NSFC) in 2007, was awarded with an honor of State New Century Hundreds-thousands Talent in 2009, and received the honor of State Council Special Subsidy Talent in 2012. He acted as an associate Dean for the College of Veterinary medicine from 2010-2015. He served as an Editorial Board member for a couple of scientific journals, acting as an Editor-in-Chief for the journal Asian Case Reports in Veterinary Medicine, as an associate Editor-in-Chief for the Chinese journal of Veterinary Medicine, and as an editorial board member for the journal Frontier in Agricultural Science and Engineering. He also serves as a deputy secretary for the Chinese Society of Avian Disease, and acts as an Executive Board Member for Beijing Immunology Society and for the Chinese Society of Animal Infectious Disease.

He has supervised 53 graduate students since he returned to China in 2005. Among these students, 30 graduated with PhD degrees and 23 with Master degrees. He gives lectures on Molecular Immunology, Zoonosis, Specialty English for Veterinary Major and Avian disease diagnostics and controls. He received Outstanding Teacher Honor awarded by Chinese Academy of Agricultural Sciences (2010-2014).

His research interest is primarily focused on the pathogenesis of microbial infection. He has made important contributions to the understandings of the molecular mechanism underlying IBDV and ARV-induced apoptosis in the host cells. He is also applying the knowledge gained from his basic research and expertise in molecular biology and immunology to study the persistent infection or immunosuppression of some microbial infections. The long-term objective of his studies is to provide a platform for rational design of effective vaccines to control infectious diseases of animals. He has over 50 published papers in various international Journals including Nature Immunology, J Clinical Investigation, J Immunology, Diabetes, J Biological Chemistry, J Virology, Frontier in Immunology, Frontier in Cellular and Infection Microbiology, Immunobiology, Frontier in Microbiolgy, Veterinary Microbiology, Virus Research, PLoS ONE, BBRC, Virology J, Archives of Virology and Poultry Science. He authored or coauthored 16 Animal disease control related books or chapters in Veterinary fields.

  • Innate immunity
  • Autoimmune inflammation
  • Pathogen-host interaction
  • Vaccine development
  • 2007 – Recipient, State Outstanding Talented Youth Foundation (NSFC)
  • 2009 – Recipient, State New Century Hundreds-thousands Talent
  • 2012 – Recipient, State Council Special Subsidy  for Talents
  • 2011-2014, Recipient, Chinese Academy of Agricultural Science Elite Lecturer
  • 2004 – Member of American Association of Immunologists
  • 2005 –Member of American Society of Microbiology
  • 2015 –Member of American Society for Biochemistry and Molecular Biology
  • 2005- Executive Board Member for the Beijing Society of Immunology
  • 2005 –Executive Board Member for the Chinese Society of Animal Infectious Diseases
  1. Wang B, Fu M, Liu Y, Wang Y, Li X, Cao H, and Zheng SJ* gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK. Frontier in Cellular and Infection Microbiology 2018, March 7, 8(55); 1-13, doi: 10.3389/fcimb.2018.00055
  2. Chen X, He Z, Fu M, Wang Y, Wu H, Li X, Cao H, and Zheng SJ * The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation, J Virology 2018 , Jan 10. 92(6). pii: e02101-17. doi: 10.1128/JVI.02101-17.
  3. Wang B, Duan X, Fu M, Liu Y, Wang Y, Li X, Cao H, and Zheng SJ* The Association of Ribosomal Protein L18 (RPL18) with IBDV VP3 Enhances Viral Replication, Virus Research 2018, Feb 2;245:69-79.
  4. He Z, Chen X, Fu M, Tang J, Li X, Cao H, Wang Y, and Zheng SJ*. Infectious bursal disease virus protein VP4 suppresses, type I interferon expression via inhibiting K48-linked ubiquitylation of glucocorticoid-induced leucine zipper (GILZ), Immunobiology 2018, Apr – May, 223(4-5):374-382.
  5. Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, and Zheng SJ*, gga-miR-130b suppresses infectious bursal disease virus replication via targeting the viral genome and cellular SOCS5, J Virology 2017 Dec 14;92(1). pii: e01646-17. doi: 10.1128/JVI.01646-17. Print 2018 Jan 1.
  6. Qin Y, Xu Z, Wang Y, Li X, Cao H, and Zheng SJ*, VP2 of Infectious Bursal Disease Virus induces apoptosis via triggering Oral Cancer Overexpressed 1 (ORAOV1) protein degradation. Frontiers in Microbiology 2017, July, 8(1): doi: 10.3389/fmicb.2017.01351
  7. Li X, Liu Y, Wang Y, Liu J, Li XQ, Cao H, Gao X and Zheng SJ*, Negative regulation of hepatic inflammation by the Soluble Resistance-Related Calcium Binding Protein via STAT3. Frontier in Immunology 2017, June 29, 8: 1-14 (doi: 10.3389/fimmu.2017.00709)
  8. Qin Y and Zheng SJ* .Infectious Bursal Disease Virus-Host Interactions: Multifunctional Viral Proteins that Perform Multiple and Differing Jobs. International J of Molecular Sciences 2017, 18, 161; doi:10.3390/ijms18010161
  9. Xu Z, Qin Y, Wang Y, Li X, Cao H, and Zheng SJ*,  A Critical role of bacterioferritin in Salmonella pullorum-induced IFN-β expression in DF-1 cells, Frontiers in Microbiology 2016, 7(1): doi: 10.3389/fmicb.2016.00020
  10. Wu H, H Z, Tang J, Li X, Cao H, Wang Y*, and Zheng SJ* A critical role of LAMP-1 in avian reovirus P10 degradation associated with inhibition of apoptosis and virus release. Arch Virol 2016,  161:899–911
  11. Lin W, Zhang Z, Xu Z, Wang B, Li XQ, Cao H, Wang Y*, and Zheng SJ*. The Association of Receptor of Activated Protein Kinase C 1(RACK1)with Infectious Bursal Disease Virus Protein VP5 and VDAC2 Inhibits Apoptosis and Enhances Viral Replication. J Biol Chem. 2015, 290(13): 8500-10.
  12. Zhang Z, Lin W, Wu H, Li XQ, Cao H, Wang Y*,and Zheng SJ*, Critical Roles of Eukaryotic Elongation Factor 1 alpha (eEF1A1) in Avian Reovirus Sigma C-induced Apoptosis and Inhibition of Viral Growth. Archives of Virology 2015, 160:1449–1461.
  13. Zheng W, Li X, Wang J, Li XQ, Cao H, Wang Y, Zeng Q*, and Zheng SJ*. A critical role of interferon-induced protein IFP35 in Foot-and-Mouth Disease Virus (FMDV) protein 2C-induced type I interferon response in cells. Archives of Virology 2014, 159(11):2925-35.
  14.   Li X, Wang J, Liu J,Li Z, Wang Y, Xue Y, Li XQ, Cao H, and Zheng SJ*. Engagement of Soluble Resistance-Related Calcium Binding Protein (sorcin) with foot-and-mouth disease virus (FMDV) VP1 inhibits type I interferon response in cells, Vet Microbiology 2013,166: 35–46. 
  15. Li Z, Wang Y, Li X, Li XQ, Cao H, and Zheng SJ*. Critical Roles of Glucocorticoid-Induced Leucine Zipper in Infectious Bursal Disease Virus (IBDV)-induced Suppression of Type I Interferon Expression and Enhancement of IBDV Growth in Host Cells via Interaction with VP4. Journal of Virology 2013, 87(2):1221-1231.
  16. Li X, Li XQ, Cao H, Wang Y, and Zheng SJ*. Engagement of new castle disease virus (NDV) matrix (M) protein with charged multivesicular body protein (CHMP) 4 facilitates viral replication. Virus Research 2013, 171: 80-88.
  17. Wang J, Wang Y, Liu J, Ding L, Zhang Q, Li X, Cao H, Tang J, and Zheng SJ*. A critical role of N-myc and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV) 2C-induced apoptosis. Virus Research 2012, 170 (2012) 59– 65.
  18. Luo Z, Li Z, Chen K, Liu R, Li X, Cao H, and Zheng SJ*. Engagement of Heterogeneous Nuclear Ribonucleoprotein M with Listeriolysin O Induces Type I Interferon Expression and Restricts Listeria Monocytogenes Growth in Host Cells. Immunobiology 2012, 217(10): 972-981.
  19. Li Z, Wang Y, Xue Y, Li X, Cao H, and Zheng SJ*. A critical role for voltage-dependent anion channel (VDAC) 2 in infectious bursal disease virus (IBDV)-induced apoptosis in host cells via interacting with VP5. Journal of Virology 2012, 86(3): 1328-1338.
  20. Ruan W, Wu Y, Zheng SJ*. Different genetic patterns in avian Toll-like receptor (TLR)5 genes. Mol Biol Rep. 2012, 39(4)3419-26.
  21. Ruan WK, Wu YH, An J, Cui DF, Li HR, Zheng SJ*. Toll-like receptor 2 type 1 and type 2 polymorphisms in different chicken breeds. Poultry Science. 2012, Jan; 91(1):101-6.
  22. Ruan Q, Kameswaran V, Zhang Y, Zheng S, Sun J, Wang J, Devirgiliis J, Liou HC, Beg AA, Chen YH. The Th17 immune response is controlled by the Rel-ROR{gamma}-ROR{gamma}T transcriptional axis. J Exp Med. 2011 Oct 24; 208 (11):2321-33.
  23. Ruan WK, Zheng SJ*. Polymorphisms of chicken toll-like receptor 1 type 1 and type 2 in different breeds. Poultry Science 2011, Sep; 90(9):1941-7.
  24. Li H, Li X, Lu Y, Wang X, Zheng SJ*. Staphylococcus sciuri exfoliative toxin C is a dimer that modulates macrophage functions. Can. J. of Microbiology 2011, 57: 722-729.
  25. Li H, Wang Y, Ding L, and Zheng SJ*. Staphylococcus sciuri exfoliative toxin C (ExhC) is a necrosis-inducer for mammalian cells. PLoS ONE 2011, 6 (7): e23145: 1-9.
  26. Li H, He F, Zhang Z, Zheng SJ*. Critical roles of amino acids Ser231, His107 and Asp156 of Staphylococcus sciuri exfoliative toxin C (ExhC) in the induction of skin exfoliations of neonate. Biologia 2011: 90-11C
  27. Chen K, Luo Z, Tang J, Zheng SJ*. A critical role of heat shock cognate protein 70 in Apoptin-induced phosphorylation of Akt. Biochem Biophys Res Commun. 2011 Jun 3; 409(2):200-4.
  28. Chen K, Luo Z, Zheng SJ*. Gallus Heat shock cognate protein 70, a novel binding partner of Apoptin. Virol J. 2011 Jun 27; 8: 324-333.
  29. Ruan Q, Zheng SJ, Palmer S, Carmody RJ, Chen YH. Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes. Diabetes 2010, Oct; 59(10):2549-57.
  30. Pang P, Chen FY, Tang J, Ma LF, Wang JC, Zheng SJ*. Avian leukosis virus p27 inhibits tumor necrosis factor αexpression in RAW264.7 macrophages after stimulation with lipopolysaccharide. Acta Virologica 2010, 54:119-124.
  31. Wang L, Suo X,Chen Y and Zheng SJ* Expression of Newcastle disease virus (NDV) M protein from a recombinant plasmid prolongs the survival of NDV-infected chicken embryos and enhances the virus replication. Acta Virologica 2009, 53:105-110.
  32. Wang Y, Lu Y, Duo Y, Wang Y,Chen F,Yang H, Zheng SJ*. Enhanced resistance of restraint stressed mice to sepsis. Journal of Immunology 2008, 181:3441-3448.
  33. Chen S, Wang Y, Chen F, Yang H, Menghou Gan and Zheng SJ*. A highly pathogenic strain of Staphylococcus sciuri caused fatal exudative epidermitis in piglets. PLoS ONE 2007, 2(1)e147: 1-6.
  34. Hilliard A, Hilliard B, Zheng SJ, Sun H, Takashi M, Song W and Chen YH. Translational regulation of autoimmune inflammation and lymphoma by programmed cell death 4. Journal of Immunology 2006,177 (11):8095-8102.
  35. Zheng SJ, L-Cherradi S, Wang P, Xu LY and Chen YH. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 2005, 54: 1423-1428.
  36. Zheng SJ, Jiang J., Shen H., and Chen YH. Reduced apoptosis and listeriosis in TRAIL-null mice. Journal of Immunology 2004, 173: 5652-5658.
  37. Zheng SJ, Wang P., Tsabary G. and Chen YH. Critical role of TRAIL in hepatic cell death and hepatic inflammation. Journal of Clinical Investigation 2004, 113(1): 58-64.
  38. L-Cherridi S*, Zheng SJ*(*Co-first author), Maguaschak, KA and Chen YH. Defective thymocyte apoptosis and accelerated autoimmunune diseases in TRAIL-Null mice. Nature Immunology 2003, 4(3): 255-260.  *Note: The first two authors contributed equally to this study.
  39. L-Cherradi S, Zheng SJ and Chen YH. Critical role of tumor necrosis factor-related apoptosis-inducing ligand in type I diabetes. Diabetes 2003, 52: 2274-2278.
  40. Zheng SJ and Chen YH. TRAIL, Bim and thymic negative selection. Immunological Research 2003, 28/3: 293-299.
  41. L-Cherradi S, Zheng SJ, Hilliard BA, Xu L, Sun J, Alsheadat S and Chen YH. Transcriptional regulation of type I diabetes by nuclear factor-KB. Journal of Immunology 2003, 171:  4886-4892.