The Online International  Journal of Onco Scientific Networks & Oncology is a peer-reviewed open acess journal that publishes original research articles as well as review articles in all areas of Oncology. this practical journal also includes information on new products, new therapies and patient management, as well as reviews of the latest research. Cancer is a complex problem. The international effort to understand and control it involves clinicians trained in many branches of medicine and scientists from most biological disciplines, chemistry, pharmaceutical and physical sciences The International Online Journal of Cancer & Therapeutics exists to serve the needs of this diverse community, providing a forum for prompt communication of original and innovative research findings that have relevance to understanding the etiology of cancer and to improving the treatment and survival of patients.

The journal publishes important original studies, reviews, and perspectives within the major topic areas of biology of premalignancy, risk factors and risk assessment, early detection research, immunoprevention, and chemopreventive and other interventions, including the basic science behind them. This journal comprises preclinical, clinical and translational research, with special attention given to molecular discoveries and an emphasis on building a translational bridge between the basic and clinical sciences. Main focuses of interest include: systemic anticancer therapy (with specific interest on molecular targeted agents and new immune therapies), randomized trials (including negatives ones), top-level guidelines, and new fields currently emerging as key components of personalized medicine, such as molecular pathology, bioinformatics, modern statistics, and biotechnologies. Radiotherapy, surgery and pediatrics manuscripts can be considered if they display a clear interaction with one of the fields above or are paradigm-shifting.

Oncology is the diagnosis and treatment of cancers,including breast,prostate,colon,lung and ovarian cancers as well as brain tumors,leukemia,lymphoma and many other types of cancer.. A doctor who works in the field of oncology is called an oncologist. The primary regions of oncology are radiation, which is worried with radiation treatment, or radiotherapy; surgical, which is contained specialists who spend significant time in tumor evacuation; therapeutic, which manages disease drugs, including chemotherapy; and interventional, which includes interventional radiologists who have some expertise in insignificantly obtrusive picture guided tumor treatment.




Anjia Han


  • 7/2012-8/2012 -  Clinical Visitor, Department of Pathology, University of Texas Southwestern Medical Center, USA
  • 2006,10-2007,9 Postdoctoral researcher, Department of Pathology, University of Illinois at Chicago, Chicago, USA.
  • 2006,5-2006,9 Postdoctoral researcher, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, USA
  • 2004,10-2006,4 Postdoctoral researcher, Department of Pathology, University of Pittsburgh, Pittsburgh, USA 1998, 9-2002,12 Ph.D., Department of Pathology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • 1993,9-1996,7 MS, Department of Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou, China 1988,9-1993,7 BS, Clinic Medicine, Shanxi Medical College, Taiyuan, China 

1. Tang J, Shi H, Li H, Zhen T, Dong Y, Zhang F, Yang Y, Han A*.The interaction of hepatoma-derived growth factor and β-catenin promotes tumorigenesis of synovial sarcoma. Tumour Biol. 2016 Aug;37(8):10287-301.
2. Tang J, Shi H, Dong Y, Zhen T, Li H, Zhang F, Han A*.The interaction of SS18 and β-catenin promotes tumorigenesis of synovial sarcoma. Int J Clin Exp Pathol. 2016
3. Shi H, Zhen T, Zhang F, Dong Y, Han A*.Multifocal epithelioid angiosarcoma of the jejunum: a case report. Pathology. 2016 Jan;48(1):91-3
4. Liang J, Chen Y, Zhang F, Shi H1,Dong Y, Li H, Zhen T, Han A*. Genomic variation of Epstein-Barr virus in inflammatory pseudotumor-like follicular dendritic cell tumor. Histopathology. 2016 Nov;69(5):883-884.
5. Chen Y, Shi H, Li H, Zhen T, Han A*.Clinicopathological features of inflammatory pseudotumour-like follicular dendritic cell tumour of the abdomen.Histopathology. 2016 May;68(6):858-65
6. Shi H, Zou T, Li H, Zhen T, Zhang F, Han A*.Malignant perivascular epithelioid cell tumour with rhabdomyosarcomatous differentiation of the pelvic cavity.Histopathology. 2016 Apr;68(5):763-6.
7. Chen J, Yan Z, Zeng H, Li H, Han A*.Teaching NeuroImages: Primary dural mucosa-associated lymphoid tissue lymphoma. Neurology 2015, 84(14): e107-8
8. Lian J, Tang J, Shi H, Li H, Zhen T, Xie W, Zhang F, Yang Y, Han A*. Positive feedback loop of hepatoma-derived growth factor and β-catenin promotes carcinogenesis of colorectal cancer. Oncotarget. 2015 ;6(30):29357-74
9. Wang F, Tang J, Wang J, Shi H, Han A*. A rare perivascular epithelioid cell tumor (PEComa) of the duodenum misdiagnosed by endoscopic needle aspiration biopsy. Pathology 2015 Dec;47(7):695-8.
10. Chen Y, Wang F, Han A. Fat-forming solitary fibrous tumor of the kidney: a case report and literature review. Int J Clin Exp Pathol. 2015 Jul 1;8(7):8632-5.
11. Shi H, Tang Q, Zhen T, Li H, Zhang F, Han A*. Yolk sac tumor of the external auditory canal: a case report and literature review. Int J Clin Exp Pathol. 2015 Nov 1;8(11):15001-6
12. Shi H, Li H, Zhen T, Zhang F, Dong Y, Zhang W, Han A*.Clinicopathological features of angiomatoid fibrous histiocytoma: a series of 21 cases with variant morphology. Int J Clin Exp Pathol. 2015 Jan 1;8(1):772-8. 13. Zhen T, Dai S, Li H, Yang Y, Kang L, Shi H, Zhang F, Yang D, Cai S, He Y, Liang Y, Han A*. MACC1 promotes carcinogenesis of colorectal cancer via β-catenin signaling. Oncotarget. 2014; 5(11):3756-69
14. Li H, Dai S, Zhen T, Shi H, Zhang F,Yang Y, Kang L, Liang Y, Han A*. Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. Eur J cancer 2014, 50(6):1207-1221
15. Yang Y, Zhen T, Zhang F, Dai S, Kang L, Liang Y, Xue L, Han A*. p53 and hepatoma-derived growth factor expression and their clinicopathological association with Ewing family tumour.J Clin Pathol. 2014; 67(3):235-42. (IF 2.44)
16. Cao Q, Liu F, Niu G, Xue L, Han A*. Blastic plasmacytoid dendritic cell neoplasm with EWSR1 gene rearrangement.J Clin Pathol. 2014 Jan;67(1):90-2. (IF 2.44)
17. Yang Y, Li H, Zhang F, Shi H, Zhen T, Dai S, Kang L, Liang Y, Wang J, Han A*. Clinical and biological significance of hepatoma-derived growth factor in Ewing's sarcoma. J Pathol. 2013 Nov;231(3):323-34.
18. Hu K, Liao D, Wu W, Han AJ, Shi HJ, Wang F, Wang X, Zhong L, Duan T, Wu Y, Cao J, Tang J, Sang Y, Wang L, Lv X, Xu S, Zhang RH, Deng WG, Li SP, Zeng YX, Kang T*.. Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma.Oncotarget 2013 Mar 21. [Epub ahead of print]
19. Zhang F, Yang Q, Meng F, Shi H, Li H, Liang Y, Han A*. Astrocyte elevated gene-1 interacts with β-catenin and increases migration and invasion of colorectal carcinoma. Mol Carcinog. 2013 Aug;52(8):603-10
20. Meng F, Li H, Shi H, Yang Q, Zhang F, Yang Y, Kang L, Zhen T, Dai S, Dong Y, Han A*. MACC1 down-regulation inhibits proliferation and tumourigenicity of nasopharyngeal carcinoma cells through Akt/β-catenin signaling pathway. PLoS One. 2013;8(4):e60821.
21. Chen W, Shi H, Liu Y, Ke Z, Han A*. Endotracheal angiomatoid 'malignant' fibrous histiocytoma: EWSR1 gene rearrangement.Pathology. 2013 Aug;45(5):506-8
22. Ye Z, Cao Q, Niu G, Liang Y, Liu Y, Jiang L, Yu X, Han A*. p63 and p53 expression in extranodal NK/T cell lymphoma, nasal type. J Clin Pathol. 2013 Aug;66(8):676-80.
23. Tang QL, Xie XB, Wang J, Chen Q, Han AJ, Zou CY, Yin JQ, Liu DW, Liang Y, Zhao ZQ, Yong BC, Zhang RH, Feng QS, Deng WG, Zhu XF, Zhou BP, Zeng YX, Shen JN, Kang T. Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma . J NATL CANCER I, 2012 May 16;104(10):749-63.
24. Liu D, Shi H, Ke Z, Han A*. Primary cardiac diffuse large B-cell lymphoma, non-germinal centre B-cell type in an immunocompetent woman. Interact Cardiovasc Thorac Surg. 2012 Aug;15(2):282-4.
25. Xiao P, Shi H, Zhang H, Meng F, Peng J, Ke Z, Wang K, Liu Y, Han A*. Epstein-Barr virus-associated intrahepatic cholangiocarcinoma bearing an intense lymphoplasmacytic infiltration. J Clin Pathol. 2012 Jun;65(6):570-3.
26. Song Y, Yang QX, Zhang F, Meng F, Li H, Dong Y, Han A*. Suppression of nasopharyngeal carcinoma cell by targeting β-catenin signaling pathway. Cancer Epidemiol. 2012; 36(2):e116-21
27. Cai XD, Zhou YB, Huang LX, Zeng QL, Zhang LJ, Wang QQ, Li SL, Feng JQ, Han AJ. Reduced expression of Krüppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma. Biochem Biophys Res Commun. 2012 Feb 3;418(1):67-73.
28. Sun S, Ke Z, Wang F, Li S, Chen W, Han A, Wang Z, Shi H, Wang LT, Chen X. Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Hum Pathol. 2012 Jul;43(7):1051-60.
29. Wang Z, Yang S, Shi H, Du H, Xue L, Wang L, Dong Y, Han A*. Histopathological and immunophenotypic features of testicular tumour of the adrenogenital syndrome. Histopathology 2011;58(7):1013-8
30. Ye Z, Xiao Y, Shi H, Ke Z, Liu Y, Liang Y, Han A*. Sporadic Burkitt lymphoma in southern China: 12 years' experience in a single institution in Guangzhou. J Clin Pathol. 2011 Dec;64(12):1132-5.
31. Zhang F, Meng F, Li H, Dong Y, Yang W, Han A*. Suppression of retinoid X receptor alpha and aberrant β-catenin expression significantly associates with progression of colorectal carcinoma. Eur J Cancer. 2011 Sep;47(13):2060-7.
32. Ye C, Pan L, Huang Y, Ye R, Han A, Li S, Li X, Wang S. Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations. J Vasc Surg. 2011 Dec;54(6):1760-1768.e3
33. Ye C, Yin H, Lin Y, Zhou L, Ye R, Li X, Han A, Wang S. Abdominal Aorta Aneurysms in Children: Single-Center Experience of Six Patients. Ann Thorac Surg. 2011 Jan;93(1):201-5
34. You S, Zhang F, Meng F, Li H, Liu Q, Liang Y, Dong Y, Yang W, Han A*. EBV-encoded LMP1 increases nuclear β-catenin accumulation and its transcriptional activity in nasopharyngeal carcinoma. Tumour Biol. 2011 Aug;32(4):623-30.PMID: 21336584
35. Ye Z,Shi H, Peng T, Han A*.Clinical and pathological features of high grade primary cardiac osteosarcoma. Interact Cardiovasc Thorac Surg. 2011 Jan;12(1):94-5 PMID: 21098423
36. Xiao P, Liu D, Peng J, Gao Z, Dong Y, Wu H, Han A*. Aggressive angiomyxoma of sphenoidal sinus. Pathology 2011;43(1):79-81 PMID: 21240074
37. Liu D,Xiao P, Gao Z, Xue L, Wang L, Liu Y, Han A*.Chondroblastoma with adamantinoma differentiation of the calcaneus. Pathology 2011;43(2):174-176 PMID: 21233685
38. Yang J, Zhang F, Fang H, Ye Z, Lin S, Han A*. Clinicopathologic features of primary lymphoma in soft tissue. Leuk Lymphoma. 2010 Nov;51(11):2039-46 PMID: 20929318
39. Fang HQ, Yang J, Zhang FF, Cui Y, Han AJ*. Clinical and Pathological features of Gastric glomus tumors. World J Gastroenterology, 2010;16(36): 4616-4620 PMID: 20857536
40. Liu Q, Han A*, You S, Yang Q, Liang Y, Dong Y. The association of genomic variation of Epstein–Barr virus BamHI F fragment with the proliferation of nasopharyngeal carcinoma. APMIS 2010; 118(9):657-64. PMID: 20718717
41. Liu L, Wu J, Ying Z, Chen B, Han A, Liang Y, Song L, Yuan J, Li J, Li M. Astrocyte elevated gene-1 upregulates matrix metalloproteinase- 9 and induces human glioma invasion. Cancer Res. 2010; 70(9):3750-9 PMID: 20388776
42. Fang W, Han A, Bi X, Xiong B, Yang W. Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling. Int J Cancer. 2010; 127(1): 32-42 PMID: 19904745
43. Hu D, Bi X, Fang W, Han A, Yang W. GSK3β is involved in JNK2-mediated β-catenin inhibition. PLoS One. 2009 Aug 13;4(8):e6640 PMID: 19675674
44. Wang Z, Yang Shicong, Wang LT, Han A*. Primary extrauterine undifferentiated endometrial sarcoma with osseous and cartilaginous differentiation. Pathology, 2009; 41(5):503-505 PMID: 19900096
45. Han A., Tong C., Hu D.,Bi X., Yang W. A direct protein-protein interaction is involved in the suppression of β-catenin transcription by retinoid X receptor α in colorectal cancer cells. Cancer Biol Ther. 2008; 7(3) 454-459 PMID: 181196974
46. Han A.,Song Z, Tong C, Hu D, Bi X, Augenlicht LH, Yang W.Sulindac suppresses β-catenin expression in human cancer cells. Eur J Pharmacol. 2008; 583(1) 26-31 PMID: 18291362
47. Hu D, Fang W, Han A, Gallagher L, Davis RJ, Xiong B, Yang W. c-Jun NH2-terminal kinase 1 interacts with and negatively regulates Wnt/{beta}-catenin signaling through GSK3{beta}pathway. Carcinogenesis. 2008;29(12):2317-24 PMID: 18952597
48. Feng C, Han A, Ye C, Xu R, Li M. The HMG-CoA Reductase Pathway, Statins and Angioprevention. Semin Ophthalmol. 2006, 21(1):29-35 PMID: 16517442
49. Han AJ*, Xiong M, Gu YY, et al. Lymphoepithelioma-like carcinoma of the lung with a better prognosis: A clinicopathologic study of 32 cases. Am J Clin Pathol 2001,115(6): 841-850 PMID: 11392880
50. Han AJ*, Xiong M, Zong YS. Association of Epstein-Barr Virus with lymphoepithelioma-like carcinoma of the lung in Southern China. Am J Clin Pathol 2000,114(2):220-226 PMID: 10941337