Dr. Uhlenhaut was born in Braunschweig, Germany, and holds a Master’s degree in Biotechnology from the Technical University (of Braunschweig). She received additional training at the Georgia Institute of Technology in Atlanta, USA, from where she holds a Master of Science in Applied Biology, at the Salk Institute for Biological Studies in LaJolla, California, and at the German Cancer Research Center in Heidelberg. She graduated with a Ph.D. Degree in Molecular Biology from the EMBL University of Heidelberg Joint International Ph.D. Program in 2007. During that time, Dr. Uhlenhaut got interested in understanding mechanisms of transcriptional regulation, specifically by using genome wide approaches. During her postdoctoral training in the lab of Dr. Ron Evans at the Salk Institute in San Diego, she focused on applying NGS techniques to study mechanisms of transcriptional repression by nuclear hormone receptors. She returned to the Max Delbrück Center for Molecular Medicine in Berlin, Germany in 2010 and was recruited to the Helmholtz Diabetes Center in Munich in 2013. Her lab uses a combination of mouse genetics, cutting edge genomics, bioinformatics, proteomics and molecular biology techniques to identify gene networks governing metabolic homeostasis.
Current Research
Nuclear Hormone Receptors in metabolic homeostasis
NGS (ChIP-Seq, RNA-Seq, bioinformatics)
Mouse models (metabolic disease, inflammation)
Transcriptional Regulation
Interested topics
Non-coding parts of the genome (ncRNAs, enhancers, promoters, 3D genome organization)
Transcription & chromatin modifications
Diabetes, obesity, immunometabolism, inflammation
Nuclear receptors
2015 – Recipient, Friedmund Neumann Prize of the Schering Foundation
2014 – Recipient, ERC Starting Grant
2013 – Recipient, Emmy Noether Program Award
2010 - DAAD travel grants
2010 – EMBO Long Term Fellowship
2008 – Fritz Thyssen Foundation Postdoc Fellowship
The Salk Institute, La Jolla, CA, USA
Northwestern School of Medicine, Chicago, IL, USA
University of Groningen Medical Center, The Netherlands
Ulm University, Germany
The University of Milan, Italy
Venetian Institute of Molecular Medicine, Padova, Italy
UPenn, Philadelphia, USA
Max Planck Institute for Biochemistry, Munich, Germany
Charite Hospital, Berlin, Germany
LMU Munich, Germany
Editorships
Editorial Board Member, Nuclear Receptor Research
Reviewing activities for EMBO J, Sci Reports, PLOS, MolMetab, FEBS Letters etc.
Conference Organization
Topic Day, Diabetes, Helmholtz Center Munich
Membership
2014 – AcademiaNet
2014 – 64th Lindau Nobel Laureate Meeting
2014- Young Leaders in Science (Schering Foundation)
2010 – Robert Bosch Foundation Fast Track Program
2010 – Helmholtz Mentoring Program Taking The Lead