International journal of Nanoparticles and Nanotechnology (IJNN) is a multidisciplinary, peer reviewed journal which includes all the major fields in nanotechnology and Nano science. Nanoscience and nanotechnology brought up an unprecedented excitement in the scientific and engineering communities, especially the last decade. It is the engineering of functional systems at the molecular scale. This covers both current work and concepts that are more advanced.  International journal of Nanoparticles and Nanotechnology   publishes original research papers during a broad area of nanoscience & engineering. IJNN provides an ideal forum for presenting original reports of theoretical and experimental nanoscience and nanotechnology research. Nanotechnology is a gathering of rising innovations in which the structure of matter is controlled at the nanometer scale, the size of little quantities of molecules, to create novel materials and gadgets that have valuable and one of kind properties. IJNN is naturally multidisciplinary, and welcomes submissions across biological, physical, engineering, and computer sciences. Contributions from both academia and industry are equally encouraged. IJNN also publishes innovative techniques and instrumentation for the fabrication, characterization and testing of nano-enabled devices and technologies, as well as advanced modelling and simulation methods.


committee

Members

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Xiaohong Li

Professor

I received my B.A. in 1991 from Fudan University, M.Sc. in Polymer Chemistry and Physics in 1994 from Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, and Ph.D. in Chemistry in 1999 from Institute of Chemistry, Chinese Academy of Sciences.

I was a postdoctoral fellow in College of Pharmacy, Ohio State University (2000-2002) and Department of Biomedical Engineering, Johns Hopkins University (2002-2004).

current research interests are biomaterials design, controlled drug release for cancer treatment and tissue regeneration.

  1. Y.W. Liu, T. Xia, J.J. Wei, Q.J. Liu, X.H. Li*. Micropatterned coculture of cardiac myocytes on fibrous scaffolds for predictive screening of drug cardiotoxicities. Nanoscale, 9, 4950–4962 (2017).
  2. L. Zhao, T. Wang, Q. Wu, Y. Liu, Z.J. Chen, X.H. Li*. Fluorescent Strips of Electrospun Fibers for Ratiometric Sensing of Serum Heparin and Urine Trypsin. ACS Appl. Mater. Interfaces, 9, 3400–3410 (2017).
  3. M.H. Chen, Y. Zhang, Z.J. Chen, S.Z. Xie, X.M. Luo, X.H. Li*. Synergistic antitumor efficacy of redox and pH dually responsive micelleplexes for co-delivery of camptothecin and genes. Acta Biomater., 49, 444–455 (2017).
  4. L. Zhao, S.Z. Xie, X.J. Song, J.J. Wei, Z. Zhang, X.H. Li*. Ratiometric fluorescent response of electrospun fibrous strips for real-time sensing of alkaline phosphatase in serum. Biosens. Bioelectron., 91, 217–224 (2017).
  5. S.W. Wang, Q. Feng, J.S. Sun*, F. Gao, W. Fan, Z. Zhang, X.H. Li*, X.Y. Jiang*. Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding. ACS Nano, 10, 298−306 (2016).
  6. J.J. Wei, J.F. Lu, Y.W. Liu, S.L. Yan, X.H. Li*. Spheroid culture of primary hepatocytes with short fibers as a predictable in vitro model for drug screening. J. Mater. Chem. B., 4, 7155–7167 (2016).
  7. S.Z. Xie, S.H. Tai, H.X. Song, X.M. Luo, H. Zhang, X.H. Li*. Genetically engineering of Escherichia coli and immobilization on electrospun fibers for drug delivery purposes. J. Mater. Chem. B., 4, 6820–6829 (2016).
  8. Y.W. Liu, J.F. Lu, G.S. Xu, J.J. Wei, Z.B. Zhang*, X.H. Li*. Tuning the conductivity and inner structure of electrospun fibers to promote cardiomyocyte elongation and synchronous beating. Mater. Sci. Eng. C, 69, 865–874 (2016).
  9. Z.J. Chen, N. He, M.H. Chen, L. Zhao, X.H. Li*. Tunable conjugation densities of camptothecin on hyaluronic acid for tumor targeting and reduction-triggered release. Acta Biomater., 43, 195–207 (2016).
  10. S.W. Wang, J.S. Sun*, Y.X. Jia, L. Yang, N.X. Wang, Y.L. Xianyu, W.W. Chen, X.H. Li*, R.T. Cha, X.Y. Jiang*. Nanocrystalline cellulose-assisted generation of silver nanoparticles for nonenzymatic glucose detection and antibacterial agent. Biomacromolecules, , 17, 2472−2478 (2016).
  11. J.M. Chen, Z.G. Liu, M.H. Chen, H. Zhang, X.H. Li*. Electrospun gelatin fibers with a multiple release of antibiotics accelerate dermal regeneration in infected deep burns. Macromol. Biosci., 16, 1368−1380 (2016).
  12. H. Zhang, Y. Liu, M.H. Chen, X.M. Luo, X.H. Li*. Shape effects of electrospun fiber rods on the tissue distribution and antitumor efficacy. J. Controlled Release, 244, 52−62 (2016).
  13. X.M. Luo,# G.S. Xu,# J.J. Wei, M.H. Chen, H. Zhang, X.H. Li*. Tunable release of chemotherapeutic and vascular disrupting agents from injectable fiber fragments potentiates combination chemotherapy. Int. J. Pharm., 506, 1–12 (2016).
  14. Y.W. Liu, J.J. Wei, J.F. Lu, D.M. Lei, S.L. Yan, X.H. Li*. Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism. Mater. Sci. Eng. C, 63, 475–484 (2016).
  15. S.W. Wang, Q. Feng, J.S. Sun*, F. Gao, W. Fan, Z. Zhang, X.H. Li*, X.Y. Jiang*. Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding. ACS Nano, 10, 298−306 (2016).
  16. X.M. Luo, M.H. Chen, Y. Zhang, Z.J. Chen, X.H. Li*. Pharmacokinetics and antitumor efficacy of micelles assembled from multiarmed amphiphilic copolymers with drug conjugates in comparison with drug-encapsulated micelles. Eur. J. Pharm. Biopharm., 98, 9–19 (2016).
  17. S.L. Yan, J.J. Wei, Y.W. Liu, H. Zhang, J.M. Chen, X.H. Li*. Hepatocyte spheroid culture on fibrous scaffolds with grafted functional ligands as an in vitro model for predicting drug metabolism and hepatotoxicity. Acta Biomater., 28, 138–148 (2015).
  18. H.Y. Li, H.Y. Wan, T. Xia, M.H. Chen, Y. Zhang, X.M. Luo, X.H. Li*. Therapeutic angiogenesis in ischemic muscles after local injection of fragmented fibers with loaded traditional Chinese medicine. Nanoscale, 7, 13075–13087 (2015)
  19. J.J. Wei, X.M. Luo, M.H. Chen, J.F. Lu, X.H. Li*. Spatial distribution and antitumor activities after intratumoral injection of fragmented fibers with loaded hydroxycamptothecin. Acta Biomater., 23, 189–200 (2015)
  20. L. Zhao, Y.F. Chen, J. Yuan, M.H. Chen, H. Zhang, X.H. Li*. Electrospun fibrous mats with conjugated tetraphenylethylene and mannose for sensitive turn-on fluorescent sensing of Escherichia coli. ACS Appl. Mater. Inter., 7, 5177−5186 (2015).
  21. Y. Zhang, M.H. Chen, X.M. Luo, H. Zhang, C.Y. Liu, H.Y. Li, X.H. Li*. Tuning multiple arms for camptothecin and folate conjugations on star-shaped copolymers to enhance glutathione-mediated intracellular drug delivery. Polym. Chem., 6, 2192 – 2203 (2015).
  22. H.N. Li, Y.W. Liu, J.F. Lu, J.J. Wei, X.H. Li*. Micropatterned coculture of vascular endothelial and smooth muscle cells on layered electrospun fibrous mats toward blood vessel engineering. J. Biomed. Mater. Res. Part A, 10.1002/jbm.a.35332.
  23. Y.W. Liu, J.F. Lu, H.N. Li, J.J. Wei, X.H. Li*. Engineering blood vessels through micropatterned coculture of vascular endothelial and smooth muscle cells on bilayered electrospun fibrous mats with pDNA inoculations. Acta Biomater., 11, 114–125 (2015).
  24. C.Y. Liu, J. Yuan, X.M. Luo, M.H. Chen, Z.J. Chen, Y.C. Zhao, X.H. Li*. Folate decorated and reduction-sensitive micelles assembled from amphiphilic polymer–camptothecin conjugates for intracellular drug delivery. Mol. Pharm., 11, 4258−4269 (2014). (ACS Editors’ Choice)
  25. X.M. Luo, H. Zhang, M.H. Chen, J.J. Wei, Y. Zhang, X.H. Li*. Antimetastasis and antitumor efficacy promoted by sequential release of vascular disrupting and chemotherapeutic agents from electrospun fibers. Int. J. Pharm., 475, 438–449 (2014).
  26. S.W. Wang, W. Chen, S. He, Q.L. Zhao, X.H. Li,* J.S. Sun,* X.Y. Jiang.* Mesosilica-coated ultrafine fibers for highly efficient laccase encapsulation. Nanoscale, 6: 6468–6472 (2014).
  27. Y.W. Liu, L. Zhang, J.J. Wei, S.L. Yan, J.S. Yu, X.H. Li*. Promoting hepatocyte spheroid formation and functions by coculture with fibroblasts on micropatterned electrospun fibrous scaffolds. J. Mater. Chem. B., 2, 3029–3040 (2014).
  28. X.Q. Guo, T. Xia, H. Wang, F. Chen, R. Cheng, X.M. Luo, X.H. Li*. Electrosprayed microparticles with loaded pDNA-calcium phosphate nanoparticles to promote the regeneration of mature blood vessels. Pharm. Res., 31: 874–886 (2014).
  29. Y.W. Liu, H.N. Li, S.L. Yan, J.J. Wei, X.H. Li*. Hepatocyte cocultures with endothelial cells and fibroblasts on micropatterned fibrous mats to promote liver-specific functions and capillary formation capabilities. Biomacromolecules, 15: 1044−1054 (2014).
  30. X.M. Luo, G.Q. Jia, H.X. Song, C.Y. Liu, G.N. Wu, X.H. Li*. Promoting antitumor activities of hydroxycamptothecin by encapsulation into acid-labile nanoparticles using electrospraying. Pharm. Res., 31: 46–59 (2014).
  31. L. Zhao, Q.J. Liu, S.L. Yan, Z.J. Chen, J.M. Chen, X.H. Li*. Multimeric immobilization of alcohol oxidase on electrospun fibers for valid tests of alcoholic saliva. J. Biotech., 168: 46– 54 (2013).
  32. F. Chen, H.Y. Wan, T. Xia, X.Q. Guo, H. Wang, Y.W. Liu, X.H. Li*. Promoted regeneration of mature blood vessels by electrospun fibers with loaded multiple pDNA-calcium phosphate nanoparticles. Eur. J. Pharm. Biopharm., 85: 699–710 (2013).
  33. H. Wang,Y. Zhang, T. Xia, W. Wei, F. Chen, X.Q. Guo, X.H. Li*. Synergistic promotion of blood vessel regeneration by astragaloside IV and ferulic acid from electrospun fibrous mats. Mol. Pharm., 10: 2394−2403 (2013).
  34. Y.W. Liu , L. Zhang , H.N. Li , S.L. Yan , J.S. Yu , J. Weng , X.H. Li*. Electrospun fibrous mats on lithographically micropatterned collectors to control cellular behaviors. Langmuir, 28: 17134–17142 (2012).
  35. Y.W. Liu, H.N. Li, Q.J. Liu, X.H. Li*. Micropatterned Electrospun Fibrous Scaffolds for Coculture of Hepatocytes and Fibroblasts. J. Tissue Eng. Regen. Med., 6(Suppl.1): 121 (2012).
  36. X.M. Luo, G.S. Xu, H.X. Song, S.X. Yang, S.L. Yan, G.Q. Jia, X.H. Li*. Promoted antitumor activities of acid-labile electrospun fibers loaded with hydroxycamptothecin via intratumoral implantation. Eur. J. Pharm. Biopharm., 82: 545–553 (2012).
  37. Y.W. Liu, X.H. Li,* B. Zou, J.G. Chen, Z.B. Cai, S.X. Qu, M.H. Zhu, L.M. Qian. Fretting behaviors of hot-pressed electrospun hydroxyapatite/poly(DL-lactide) fibrous composites as potential orthopaedic implants. Tribo. Int., 53: 124–133 (2012).
  38. S.H. He, T. Xia, H. Wang, L. Wei, X.M. Luo, X.H. Li*. Multiple releases of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels. Acta Biomater., 8: 2659–2669 (2012).
  39. X.J. Cai, X.H. Li,* Y.W. Liu, G.N. Wu, Y.C. Zhao, F. Chen, Z.W. Gu. Galactose decorated acid-liable nanoparticles encapsulating quantum dots for enhanced cellular uptake and subcellular localization. Pharm. Res., 29: 2167–2179 (2012).
  40. S.H. He, X.H. Li,* Y. Yang, G.Q. Jia, J. Zou. Correlations of in vitro and in vivo degradation tests on electrospun poly-DL-lactide-poly(ethylene glycol) fibers. J. Appl. Polym. Sci., 125: 2207–2215 (2012).
  41. B. Zou, X. Chen, W. Zhi, Y.W. Liu, W.G. Cui, S.C Hu, X.H. Li*. Promoted healing of femoral defects with in situ grown fibrous composites of hydroxyapatite and poly(DL-lactide). J. Biomed. Mater. Res. Part A, 100A: 1407–1418 (2012).
  42. B. Zou, Y.W. Liu, X.M. Luo, F. Chen, X.Q. Guo, X.H. Li*. Electrospun fibrous scaffolds with continuous gradations in mineral contents and biological cues for manipulating cellular behaviors. Acta Biomater., 8: 1576–1585 (2012).
  43. X.M. Luo, C.Y. Xie, H. Wang, C.Y. Liu, S.L. Yan, X.H. Li*. Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation. Int. J. Pharm., 425: 19–28 (2012).
  44. Z. Chen, X.J. Cai, Y. Yang, G.N. Wu, Y.W. Liu, F. Chen, X.H. Li*. Promoted transfection efficiency of pDNA polyplexes-loaded biodegradable microparticles containing acid-labile segments and galactose grafts. Pharm. Res., 29: 471–482 (2012).
  45. Y. Yang, T. Xia,, F. Chen, W. Wei, C.Y. Liu, S.H. He, X.H. Li*. Electrospun fibers with plasmid bFGF polyplexes loadings promote skin wound healing in diabetic rats. Mol. Pharm., 9: 48−58 (2012).
  46. Y. Yang, X.H. Li*, S.H. He, L. Cheng, F. Chen, S.B. Zhou, J. Weng. Biodegradable ultrafine fibers with core-sheath structures for protein delivery and its optimization. Polym. Adv. Technol., 22: 1842–1850 (2011).
  47. J. Zou, Y. Yang, Y.W. Liu, F. Chen, X.H. Li*. Release kinetics and cellular profiles for bFGF-loaded electrospun fibers: Effect of the conjugation density and molecular weight of heparin. Polymer, 52: 3357–3367 (2011).
  48. Y. Yang, T. Xia, W. Zhi, L. Wei, J. Weng, C. Zhang, X.H. Li*. Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor. Biomaterials, 32: 4243–4254 (2011).
  49. Y. Yang, X.H. Li*, L. Cheng, S.H. He, J. Zou, F. Chen, Z.B. Zhang. Core-sheath-structured fibers with pDNA polyplex loadings for optimal release profile and transfection efficiency as potential tissue engineering scaffolds. Acta Biomater. 7: 2533–2543 (2011).
  50. B. Zou, X.H. Li,* H.H. Zhuang, W.G. Cui, J. Zou, J.G. Chen. Degradation behaviors of electrospun fibrous composites of hydroxyapatite and chemically modified poly(DL-lactide). Polym. Degrad. Stabil., 96: 114–122 (2011).
  51. J.G. Chen, X.H. Li,* W.G. Cui, C.Y. Xie, J. Zou, B. Zou. In situ grown fibrous composites of poly(DL-lactide) and hydroxyapatite as potential tissue engineering scaffolds. Polymer, 51: 6268–6277 (2010).
  52. W.G. Cui, X.H. Li,* C.Y. Xie, J.G. Chen, J. Zou, S.B. Zhou, J. Weng. Controllable growth of hydroxyapatite on electrospun poly(DL-lactide) fibers grafted with chitosan as potential tissue engineering scaffolds. Polymer, 51: 2320–2328 (2010).
  53. W.G. Cui, X.H. Li,* C.Y. Xie, H.H. Zhuang, S.B. Zhou, J. Weng. Hydroxyapatite nucleation and growth mechanism on electrospun fibers functionalized with different chemical groups and their combinations. Biomaterials, 31: 4620–4629 (2010).
  54. C.Y. Xie, X.H. Li,* X.M. Luo, Y. Yang, W.G. Cui, J. Zou, S.B. Zhou. Release modulation and cytotoxicity of hydroxycamptothecin-loaded electrospun fibers with 2-hydroxypropyl-β-cyclodextrin inoculations. Int. J. Pharm., 391: 55–64 (2010).
  55. J.G. Chen, X.H. Li,* W.G. Cui, C.Y Xie, J. Zou, B. Zou. Fibrous composites with anisotropic distribution of mechanical properties after layer-by-layer deposition of aligned electrospun fibers. Adv. Eng. Mater., 12: B529–538 (2010).
  56. Y. Yang, X.L. Zhu, W.G. Cui, X.H. Li,* Y. Jin.* Electrospun composite mats of poly[(D,L-lactide)-co-glycolide] and collagen with high porosity as potential scaffolds for skin tissue engineering. Macromol. Mater. Eng., 294: 611–619 (2009).
  57. W.G. Cui, X.L. Zhu, Y. Yang, X.H. Li,* Y. Jin.* Evaluation of electrospun fibrous scaffolds of poly(DL-lactide) and poly(ethylene glycol) for skin tissue engineering. Mater. Sci. Eng. C, 29: 1869–1876 (2009).
  58. W.G. Cui, X.H. Li,* J.G. Chen, S.B. Zhou, J. Weng. In situ growth kinetics of hydroxyapatite on electrospun poly(DL-lactide) fibers with gelatin grafted. Cryst. Growth Des., 8: 4576–4582 (2008).
  59. G. Yu, X.H. Li,* X.J. Cai, W.G. Cui, S.B. Zhou, J. Weng. The photoluminescence enhancement of electrospun poly(ethylene oxide) fibers with CdS and polyaniline inoculations. Acta Mater., 56: 5775–5782 (2008).
  60. X.L. Zhu, W.G. Cui, X.H. Li,* Y. Jin.* Electrospun fibrous mats with high porosity as potential scaffolds for skin tissue engineering. Biomacromolecules, 9: 1795–1801 (2008).
  61. W.G. Cui, M.B. Qi, X.H. Li,* S.Z. Huang, S.B. Zhou, J. Weng. Electrospun fibers of acid-labile biodegradable polymers with acetal groups as potential drug carriers. Int. J. Pharm., 361: 47–55 (2008).
  62. M.B. Qi, X.H. Li,* Y. Yang, S.B. Zhou. Electrospun fibers of acid-labile biodegradable polymers containing ortho ester groups for controlled release of paracetamol. Eur. J. Pharm. Biopharm., 70: 445–452 (2008).
  63. W.G. Cui, X.H. Li,* S.B. Zhou, J. Weng. Degradation patterns and surface wettability of electrospun fibrous mats. Polym. Degrad. Stabil., 93: 731-738 (2008).
  64. Y. Yang, X.H. Li *, M.B. Qi, S.B. Zhou, J. Weng. Release pattern and structural integrity of lysozyme encapsulated in core-sheath structured poly(DL-lactide) ultrafine fibers prepared by emulsion electrospinning. Eur. J. Pharm. Biopharm., 69: 106–116 (2008).
  65. Y. Yang, X.H. Li *, W.G. Cui, S.B. Zhou, R. Tan, C.Y. Wang. Structural stability and release profiles of proteins from core-shell poly (DL-lactide) ultrafine fibers prepared by emulsion electrospinning. J. Biomed. Mater. Res., 86A: 374–385 (2008).
  66. W.G. Cui, X.H. Li,* S.B. Zhou, J. Weng. In situ growth of hydroxyapatite within electrospun poly(DL-lactide) fibers. J. Biomed. Mater. Res., 82A: 831–841 (2007).
  67. W.G. Cui, X.H. Li*, S.B. Zhou, J. Weng. Investigation on process parameters of electrospinning system through orthogonal experimental design. J. Appl. Polym. Sci., 103: 3105-3112 (2007).
  68. W.G. Cui, S. B. Zhou, X.H. Li*, J. Weng. Drug-loaded biodegradable polymeric nanofibers prepared by electrospinning. Tissue engineering, 12:1070 (2006).
  69. W.G. Cui, X.H. Li*, X.L. Zhu, G. Yu, S.B. Zhou, J. Weng. Investigation of drug release and matrix degradation of electrospun poly(DL-lactide) fibers with paracetanol inoculation. Biomacromolecules, 7: 1623-1629 (2006).