International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.


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Members

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MariaFoti

AssistantProfessor

Dr. Maria FOTI isassistant professor at the University of Milano-Bicocca from 2004 wheresheteaches General Pathologycourses. She is also a member of the Doctorate School in NeuroScience. She graduated in Milan and obtained her PhD in Biotechnology at the University of Milan. The research activity was on the field of dendritic cell expression profiling.She joined Prof. Castagnoli's laboratory at the CNR, center of molecular and cellular pharmacology, Milano as a postdoctoral fellow where she studied the molecular mechanisms associated to early events during dendritic cells activation and maturation. From thesestudies a role of dendriticcells in innate immunityissuggested.

she was appointed as researcher at the R & D Department of the pharmaceutical company Bayer in Milan that lately in 2001, became Axxams.r.l. (spin off of Bayer) a science-driven biotechnology company focused on early-stage discovery. Dr. Foti developsdifferentcell-basedassays for the screening of antimicrobialcompounds and discoverednovel gene reporter systemsthatlead to the inventionpatented under the application N° EP1413584. She set up the functionalgenomicslaboratory to start projects for the selection of biomarkersusing the microarraytechnology in the field of Immunology, cancer and toxicology.

From 2004 shebecameassistant professor at the University of Milano-Bicocca whereinitiallysheheaded the Research Team of Genopolis, a functionalgenomicsconsortium and AffymetrixCorelab for transcriptionalprofilinganalysis. Shecoordinated the reseachunit in the GenopolisConsortium and the externalscientificcollaborations. She started working in the research area of ImmunoGenomics where Functional Genomics studies are applied to study the trascriptomics of the cell of the immune system.

The research activity has been dedicated to the understanding of the molecular pathways regulating Dendritic Cells (DCs) and Monocytes Biology in health and disease. She has extensive experience in ImmunoGenomics of inflammatory-based diseases and Biomarkers development. She pioneered the first studies using Genome-Wide technologies to characterize the molecular mechanisms in human diseases. Dr.Foti's lab has a strong focus on cells of the innate immunity including the role of APC in autoimmunity and their regulation in tissue and organ homeostasis. She also developed a novel molecular assay that can be used as quality control in DC-based therapies and initiated a biomarker discovery program in autoimmunity and in oncology. Presently, she is studying the interaction between MSCs and DCs cells and the reciprocal molecular signals that regulate these interactions in chronic inflammatory conditions and in Cancer. She serves as a reviewer for the following Grant Agencies: Basic Research Grants Science Foundation Ireland; The Research Foundation - Flanders (FWO) agency, Belgium; Medical Research Council MRC, London UK.Peer-reviewer of scientific journals (European Journal of immunology, Inflammation Research, Journal of Immunology, BMC Immunology, Biotechniques, PlosONE and Vaccine).

CurrentResearch

  • Dendritic Cell Biology
  • Autoimmune Disorders
  • MyeloidCells-MSCsInteractions
  • Cytototoxic T cellsRegulation
     

Interested topics

  • Trained Immunity
  • Host-Pathogen Interactions
  • ImmunoGenomics
  • Immune Cells Regulation
  • 1997 – International Scholar, “HUMAN GENOME SCIENCES”, Rockville, MD. USA.
  • 1996 – Fellow, University of Zurich, Switzerland
  • 2004 – Faculty Appointment, University of Milano-Bicocca
  • 2011 – Delegation Leader, International Consortium of Cell therapy, Czech Republic and Europe (ICCT)
  • 2014 – Research Committee Coordinator, Dept. Surgery and Translation Medicine, University of Milano-Bicocca
  • 2014 – Advisory Board, Italian Consultation Board Societal Challenge 2 “Food Security, Sustainable Agriculture and Forestry, Marine and Maritime and Inland Water Research and The Bioeconomy” - Horizon 2020
  • 2015 – Expert Panel, National Agency for Evaluation of the University System and Research
  • 2016 – Expert Panel, Italian Ministry of University and Research, MIUR
  • IPBS- Université de Toulouse, Université Paul Sabatier, Institut dePharmacologie et de Biologie Structurale, Toulouse, France.
  • Institut Pasteur Unité de GénétiqueMycobactérienne,Paris, France.
  • Medical Microbiology, Centre for Infection, Division of Cellular &Molecular Medicine, St. George's University of London, Cranmer Terrace, Tooting, London, UK
  • CNRS UMR‐8162, UPS, Hôpital Marie Lannelongue, LePlessis‐Robinson, France
  • MedizinischeUniversität Innsbruck, Austria
  • Centre de BiologieStructurale et de Bioinformatique(CBSB) Structure et Fonction des Membranes Biologiques (SFMB) UniversiteLibre de Bruxelles,Bruxelles, Belgium
  • Neurology IV Department, Neuromuscular Diseases and Neuroimmunology, Fondazione Istituto Neurologico “Carlo Besta”, Milan, Italy.
  • Università Cattolica del S. Cuore, Roma
  • IRCCS S. Maria Nascente, Fondazione DonGnocchi, U.O. Sclerosi Multipla

 

  • Guest Editor for Clinical and Developmental Immunology Hindawi Publishing Corporation(http://www.hindawi.com)
  • Editorial Board Member for International Journal of Autoimmune Disorders & Therapy
  • Cytokine Effector Functions in Tissue, Elsevier editionInc