International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.




Seung-Yong Seong



Seoul National University College of Medicine


Ph.D. (Microbiology and Immunology)



Department of Microbiology and Immunology,

Seoul National University College of Medicine




M.S. (Microbiology and Immunology)



Seoul National University College of Medicine


Bachelor, Medical doctor    1990

Seoul National University College of Medicine



Letter of Commendation (Governer, Gangwon province, Minister, M. of Health and welfare, Korea)


Yuhan Medical Award, Seoul Medical Association


The best poster award, DC 2007, Bamburg, Germany


Poster Award, International Conference on Inante Immunity, Greece



Hamchun Medical Award, Seoul National University Medical College Alumni Association



Award of Young Investigator,Seoul National University Hospital


Award of excellent paper,The Korean Federation of Science and Technology Societies


Award of Bursary,Federation of Immunological Society of Australia, Immunology Workshop


Sustaining Member Travel Grant Award , 93rd General Meeting of American Society for Microbiology





Korean Society for Microbiology

Korean Society for Immunology

American Society for Microbiology

American Society for Immunology

1990~ present

1990~ present

1991 ~ present

1998 ~ present

Publications (2004~)

  • 2004

1. Seong SY, Matzinger P. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nature Reviews Immunology 2004;4:469-78.

2. Cho NH, Choi CY, Seong SY. Down-regulation of gp96 by Orientiatsutsugamushi. Microbiology and immunology 2004;48:297-305.

3. Koh YS, Yun JH, Seong SY, Choi MS, Kim IS. Chemokine and cytokine production during Orientiatsutsugamushi infection in mice. Microbial pathogenesis 2004;36:51-7.

  • 2005          

1. Yun JH, Koh YS, Lee KH, et al. Chemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientiatsutsugamushi infection. Microbiology and immunology 2005;49:551-7.

  • 2006

1. Kim DH, Cho IH, Kim HS, et al. Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression. Experimental & molecular medicine 2006;38:417-27.

  • 2008

1. Min CK, Bang SY, Cho BA, et al. Role of amphipathic helix of a herpesviral protein in membrane deformation and T cell receptor downregulation. PLoS pathogens 2008;4:e1000209.

  • 2009

1 . Nam-Hyuk Cho, Seung-Yong Seong, Apolipoproteins inhibit the innate immunity activated by necrotic cells or bacterial endotoxin , Immunology. 2009 Sep;128(1 Suppl):e479-86. Epub 2008 Dec 17.

2. Jin Hee Kim, Tae Heung Kang, Kyung Hee Noh, Hyun CheolBae, Seok-Ho Kim, Young Do Yoo, Seung-Yong Seong, Tae Woo Kim, Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8+ T cell-mediated cell death. ImmunolLett. 2009 Jan 29;122(1):58-67.

3. Lee KM, Seong SY. Partial role of TLR4 as a receptor responding to damage-associated molecular pattern. ImmunolLett. 2009 Jun 30;125(1):31-9.

4. Na HY, Mazumdar K, Moon HJ, Chang S, Seong SY. TLR4-independent and PKR-dependent interleukin 1 receptor antagonist expression upon LPS stimulation.

Cell Immunol. 2009;259(1):33-40. Epub 2009 Jun 6.

5. Kang TH, Bae HC, Kim SH, Seo SH, Son SW, Choi EY, Seong SY, Kim TW.

Modification of dendritic cells with interferon-gamma-inducible protein-10 gene to enhance vaccine potency. J Gene Med. 2009 Oct;11(10):889-98.

6. Bae MY, Cho NH, Seong SY. Protective anti-tumour immune responses by murine dendritic cells pulsed with recombinant Tat-carcinoembryonic antigen derived from Escherichia coli. ClinExpImmunol. 2009 Jul;157(1):128-38.

7. Yang H, Cho NH, Seong SY. The Tat-conjugated N-terminal region of mucin antigen 1 (MUC1) induces protective immunity against MUC1-expressing tumours. ClinExpImmunol. 2009 Nov;158(2):174-85

8. Park H, Lee K, Kim M, Lee J, Seong SY, Ko G.  Detection and hazard assessment of pathogenic microorganisms in medical wastes.  J Environ Sci Health A Tox Hazard Subst Environ Eng. 2009 Aug;44(10):995-1003.

9. Lee SH, Taek Han S, Choi SW, Seong SY, You HJ, Ye SK, Chung MH.  Inhibition of Rac and Rac-linked functions by 8-oxo-2'-deoxyguanosine in murine macrophages. Free Radic Res. 2009 Jan;43(1):78-84.

  • 2010

1.  Chun KH, Seong SY. CD14 but not MD2 transmit signals from DAMP. IntImmunopharmacol. 2010 Jan;10(1):98-106.

2. Cho BA, Cho NH, Seong SY, Choi MS, Kim IS.  Intracellular invasion by Orientiatsutsugamushiis mediated by integrin signaling and actin cytoskeleton rearrangements. Infect Immun. 2010 May;78(5):1915-23.

3. Cho BA, Cho NH, Min CK, Kim SY, Yang JS, Lee JR, Jung JW, Lee WC, Kim K, Lee MK, Kim S, Kim KP, Seong SY, Choi MS, Kim IS. Global gene expression profile of Orientiatsutsugamushi. Proteomics. 2010 Apr;10(8):1699-715.

  • 2011

1. Kang TH, Kim KW, Bae HC, Seong SY, Kim TW. Enhancement of DNA vaccine

potency by antigen linkage to IFN-gamma-inducible protein-10. Int J Cancer. 2011 Feb 1;128(3):702-14.

2. Nam-Hyuk Cho, Taek-Chin Cheong, Ji Hyun Min, Jun Hua Wu, Sang Jin Lee,

Daehong Kim, Jae-Seong Yang, SangukKim,YoungKeun Kim and Seung-Yong Seong A multifunctional core-shell nanoparticle for dendritic cell based cancer immunotherapy. Nature  Nanotech. 2011 Sep 11;6(10):675-82.

3. Choi HJ, Kim MK, Ko JH, Lee HJ, Jeong HJ, Wee WR, Seong SY, Akira S. Effect of                  Toll-like receptor 2 and 4 of corneal fibroblasts on cytokine expression with co-cultured antigen presenting cells. Cytokine. 2011 Nov;56(2):265-71.

  • 2012

1.  Zuo DC, Choi S, Shahi PK, Kim MY, Park CG, Kim YD, Lee J, Chang IY, Lee HS,                  Yeom SC, Moon HJ, Seong SY, So I, Jun JY. Action of lipopolysaccharide on interstitial cells of cajal from mouse small intestine. Pharmacology. 2012;90(3-4):151-9.

2.  Noh KH, Kim BW, Song KH, Cho H, Lee YH, Kim JH, Chung JY, Kim JH, Hewitt SM, Seong SY, Mao CP, Wu TC, Kim TW. Nanog signaling in cancer promotes stem-like phenotype and immune evasion. J Clin Invest. 2012 Nov 1;122(11):4077-93.

  • 2013

1. Lee SH, Nam KW, Jeong JY, Yoo SJ, Koh YS, Lee S, Heo ST, Seong SY, Lee KH.

The Effects of Climate Change and Globalization on Mosquito Vectors: Evidence from Jeju Island, South Korea on the Potential for Asian Tiger Mosquito (Aedesalbopictus) Influxes and Survival from Vietnam Rather Than Japan. PLoS One. 2013 Jul 24;8(7):e68512.

  • 2014

1. Lee HC, Narayanan S, Park SJ, Seong SY, Hahn YS. Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex. J Biol Chem. 2014 Apr 25;289(17):11861.

2. Noh KH, Park YM, Kim HS, Kang TH, Song KH, Lee YH, Byeon Y, Jeon HN, Jung ID, Shin BC, Lee KM, Seong SY, Han HD, Kim TW. GM-CSF-loaded chitosan hydrogel as an immunoadjuvant enhances antigen-specific immune responses with reduced toxicity. BMC Immunol. 2014 Oct 18;15:48.

  • 2015

1.Cheong TC, Shin EP, Kwon EK, Choi JH, Wang KK, Sharma P, Choi KH, Lim JM,      Kim HG, Oh K, Jeon JH, So I, Kim IG, Choi MS, Kim YK, Seong SY, Kim YR, Cho NH. Functional Manipulation of Dendritic Cells by Photoswitchable Generation of Intracellular Reactive Oxygen Species. ACS Chem Biol. 2015 Mar 20;10(3):757-65.

2. Kim JE, Hong YH, Lee JH, Ahn SW, Kim SM, Park KS, Sung JJ, Lee KW, Seong SY. Pattern difference of dissociated hand muscle atrophy in amyotrophic lateral sclerosis and variants. Muscle Nerve. 2015 Mar.51(3):333-7

3. Pattern of Respiratory Deterioration in Sporadic Amyotrophic Lateral Sclerosis According to Onset Lesion by Using Respiratory Function Tests. Kim DG, Hong YH, Shin JY, Lee KW, Park KS, Seong SY, Sung JJ.ExpNeurobiol. 2015 Dec;24(4):351-7.

4. Neuroprotective Effect of Human Adipose Stem Cell-Derived Extract in Amyotrophic Lateral Sclerosis. Jeon GS, Im W, Shim YM, Lee M, Kim MJ, Hong YH, Seong SY, Kim M, Sung JJ.Neurochem Res. 2015 Dec 8. [Epub ahead of print]

5. Modulation of SOD1 Subcellular Localization by Transfection with Wild- or Mutant-type SOD1 in Primary Neuron and Astrocyte Cultures from ALS Mice. Lee DY, Jeon GS, Shim YM, Seong SY, Lee KW, Sung JJ.ExpNeurobiol. 2015 Sep;24(3):226-34.

  • 2016

1.Neuroprotective Effect of Human Adipose Stem Cell-Derived Extract in Amyotrophic Lateral Sclerosis.Jeon GS, Im W, Shim YM, Lee M, Kim MJ, Hong YH, Seong SY, Kim M, Sung JJ. Neurochem Res. 2016 Apr:41(4): 913-23