International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.


committee

Members

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Paulo Renato Zuquim Antas

Principal Investigator

INSTITUTION AND LOCATION

DEGREE

YEAR

FIELD OF STUDY

Oswaldo Cruz Institute, FIOCRUZ, Brazil

Ph.D.

2005

Infectious Diseases, TB

Oswaldo Cruz Institute, FIOCRUZ, Brazil

M.Sc.

1996

Infectious Diseases

Federal University of Rio de Janeiro, UFRJ, Brazil

B.Sc., Professor

1992

Biology and Education

Positions and Honors.

 

Antas PRZ. Biography / Who´s Who in Medicine and Healthcare, Marquis Who, 5th and 62thEdition.

 

Positions and Employments

 

FIOCRUZ, Brazil                                                                                Current

Permanent Investigator, Research Associate

 

FOA University, Brazil                                                                           2009-2011

Associate Professor (Parasitology course)

 

Vanderbilt University Medical Center                                        2006-2007

Post-Doctoral Research Fellow

 

Vanderbilt University Medical Center                                        2004-2005

Term-Professional

 

Editorial Boards of Scientific and Scholarly Journals:

Member of the Editorial Board of the Journal of Ancient Diseases & Preventive Remedies, 2013-

Member of the Editorial Board of the Clinical Journal of Vaccines and Vaccination, 2014-

Member of the Editorial Board of the SM Vaccines and Vaccination Journal, 2015-

Member of the Editorial Board of the Journal of Clinical Infectious Diseases and Practices, 2015-

Member of the Editorial Board of the Archives of Pulmonology and Respiratory Care, 2015-

Member of the Editorial Board of the ARC Journals of Immunology and Vaccines, 2015-

Member of the Editorial Board of the Journal of Immunology and Vaccination, 2016-

Member of the Editorial Board of the Jacobs Journal of Biochemistry, 2016-

Member of the Editorial Board of the MAYFEB Journal of Medicine, 2016-

Member of the Editorial Board of the Austin Journal of Clinical Immunology, 2016-

Member of the Editorial Board of the IORE Journal of Immunology, 2016-

Member of the Editorial Board of the SciFed Journal of Immunology, 2016-

Member of the Editorial Board of the Journal of Infectious Diseases and Pathogenesis, 2016-

Member of the Editorial Board of the Lung, Pulmonary & Respiratory Research Journal, 2016-

Member of the Editorial Board of the Journal of Mucosal Immunology Research, 2017-

Member of the Editorial Board of the Insights in Tuberculosis Journal, 2017-

Member of the Editorial Board of the International Journal of Pulmonology and Infectious Diseases, 2017-

Member of the Editorial Board of the EC Paediatrics Journal, 2017-

Member of the Editorial Board of the Journal of Allergy and Immunology, 2017-

Member of the Editorial Board of the Journal of Clinical Immunology & Research, 2017-

Member of the Editorial Board of the Journal of Community and Preventive Medicine, 2017-

Member of the Editorial Board of the Clinical Research in Immunology Journal, 2017-

Member of the Editorial Board of the Journal of PeerScientist, 2017-

Member of the Editorial Board of the Journal of Hematology and Clinical Therapeutics, 2017-

Member of the Editorial Board of the Annals of Microbiology and Infectious Diseases, 2017-

Member of the Editorial Board of the Journal of Hematology and Serology, 2017-

Member of the Editorial Board of the Journal of Vaccines & Vaccination Open Access, 2017-

Member of the Editorial Board of the Journal of Acute and Chronic Disease Reports, 2017-

Member of the Editorial Board of the Journal of Chest and Lung Research, 2017-

Member of the Editorial Board of the International Journal of Paediatrics and Neonatology, 2017-

Member of the Editorial Board of the Journal of Clinical Immunology and Research, 2017-

Member of the Editorial Board of the Enliven: Immunology and Immunotechniques Journal, 2017-

Member of the Editorial Board of the Bulletin of Clinical Immunology Journal, 2018-

Member of the Editorial Board of the Frontiers in Medicine and Health Research Journal, 2018-

Member of the Editorial Board of the Journal of Emerging and Rare Diseases, 2018

 

Selected peer-reviewed publications (in chronological order).

 

  1. Acute phase protein profiles and stages in Trypanosoma cruzi-infected children: a study in Bolivian endemic areas for Chagas’ Disease. T.C. Araújo-Jorge, P.R.Z. Antas, N. Medrano-Mercado, F. Torrico, R. Correa Oliveira, A. C. L. Chaves and A. J. RomanhaProceedings of 10th International Congress of Immunology, 1998.
  2. Early, Intermediate and Late acute stages in Chagas’ disease: a study combining Anti-Galactose IgG, Specific Serodiagnosis and Polymerase chain reaction analysis. Paulo R. Z. Antas , N. Medrano-Mercado, F. Torrico, R. Ugarte-Fernandez, F. Gómez, R. Correa Oliveira, A. C. L. Chaves, A. J. Romanha and T. C. Araújo-Jorge - American Journal of Tropical Medicine and Hygiene, 61(2), 1999, pp. 308-314.
  3. A Realiable and Specific ELISA Method to Capture IgM from Human Chagasic Sera Using Fixed Epimastigotes of Trypanosoma cruzi. Paulo R. Z. Antas, Emily N. Azevedo, Maurício R. M. P. Luz, Norah Medrano-Mercado, Andréa C. L. Chaves, Pedro G. Vidigal, Ângela C. Volpini, Álvaro J. Romanha and Tânia C. Araújo-Jorge Parasitology Research, 86(10), 2000, pp. 813-820.
  4. T-Cell repertoire analysis in acute and chronic human Chagas' disease: differential frequencies of vbeta5 expressing T cells. Costa RP, Gollob KJ, Fonseca LL, Rocha MO, Chaves AC, Medrano-Mercado N, Araujo-Jorge TC, Antas PR, Colley DG, Correa-Oliveira R, Gazzinelli G, Carvalho-Parra J and Dutra WOScandinavian Journal of Immunology, 51(5), 2000, pp. 511-519.
  5. Kinetics of T Cell-Activation Molecules in Response to Mycobacterium tuberculosis Antigens. Antas PRZ, Oliveira EB, Milagres AS, Franken KLMC, Ottenhoff THM, Klatser P, Sarno EN and Sampaio EP - Memórias do Instituto Oswaldo Cruz, 97(8), 2002, pp. 1097-1099.
  1. T Cell Responses to the Mycobacterium tuberculosis Specific Antigen ESAT-6 in Brazilian Tuberculosis Patients. Cardoso FLL, Antas PRZ, Milagres AS, Geluk A, Franken KLMC, Oliveira EB, Teles RMB, Teixeira HC, Nogueira SA, Sarno EN, Klatser P, Ottenhoff THM and Sampaio EPInfection and Immunity, 70(12), 2002, pp. 6707-6714.
  2. Phenotypic Features of Peripheral Blood Leucocytes During Early Stages of Human Infection with Trypanosoma cruzi. Sathler-Avelar R, Lemos EM, Reis DD, Medrano-Mercado N, Araujo-Jorge TC, Antas PRZ, Correa-Oliveira R, Teixeira-Carvalho A, Eloi-Santos SM, Favato D, Martins-Filho OA - Scandinavian Journal of Immunology, 58(6), 2003, pp. 655-663.
  3. Whole Blood Assay to Access T Cell-Immune Responses to Mycobacterium tuberculosis Antigens in Healthy Brazilian Individuals. Antas PRZ, Cardoso FLL, Oliveira EB, Gomes PKC, Cunha KS, Sarno EN and Sampaio EP - Memórias do Instituto Oswaldo Cruz, 99(1), 2004, pp. 53-55.
  4. Patterns of intracellular cytokines in CD4 and CD8 T cells from patients with mycobacterial infections. Antas PRZ, Sales JS, Pereira KC, Oliveira EB, Cunha KS, Sarno EN and Sampaio EPBrazilian Journal of Medical and Biological Research, 37(8), 2004, pp. 1119-1129.
  5. Leishmania (Viannia) braziliensis: human mast cell line activation induced by logarithmic and stationary promastigote derived-lysates. de Oliveira MP, Lima MC, Calheiros AS, Martins MA, Antas PRZ, De Luca PM and Pirmez CExperimental Parasitology, 109(2), 2005, pp. 72-79.
  6. T cell-immune responses to Mycobacterial antigens in Brazilian tuberculosis patients and controls. Antas PRZ, Cardoso FLL, Pereira KC, Franken KLMC, Cunha KS, Klatser P, Sarno EN, Ottenhoff THM and Sampaio EPTransactions of the Royal Society of Tropical Medicine and Hygiene, 99(9), 2005, pp. 699-707.
  7. Detection of in vitro interferon-g and serum tumour necrosis factor-a in multidrug-resistant tuberculosis patients. A. Fortes, K. Pereira, P.R.Z. Antas, C. L. M. C. Franken, M. Dalcolmo, M. M. Ribeiro-Carvalho, K. S. Cunha, A. Geluk, A. Kritski, A. Kolk, P. Klatser, E. N. Sarno, T. H. M. Ottenhoff and E. P. SampaioClinical and Experimental Immunology, 141(3), 2005, pp. 541-548.
  8. Cytokines and Mycobacterium leprae Induce Apoptosis in Human Schwann Cells. Oliveira RB, Sampaio EP, Aarestrup F, Teles RM, Silva TP, Oliveira AL, Antas PRZ, Sarno EN Journal of Neuropathology and Experimental Neurology, 64(10), 2005, pp. 882-890.
  9. Does kinetics play a relevant role for intracellular staining? Antas PRZ. Microbes and Infection, 8, 2006, p. 955.
  10. Decreased CD4+ Lymphocytes and Innate Immune Responses in Adults with Prior Extrapulmonary Tuberculosis. P.R.Z. Antas, L. Ding, J. Hackman, L. Reeves-Hammock, A.K. Shintani, J. Schiffer, S.M. Holland and T.R. Sterling The Journal of Allergy and Clinical Immunology, 117(4), 2006, pp. 916-923.
  11. Another Round for the CD4+CD25+ Regulatory T Cells in Patients with Tuberculosis. Antas PRZ and Sampaio EP - American Journal of Respiratory and Critical Care Medicine, 176(2), 2007, pp. 214-215.
  12. New vaccines against tuberculosis: lessons learned from BCG immunisation in Brazil. P.R.Z. Antas and Castello-Branco L.R.R. - Transactions of the Royal Society of Tropical Medicine and Hygiene, 102(7), 2008, pp. 628-630.
  13. Polymorphisms in IL-1 beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. Alison A Motsinger-Reif, Paulo RZ Antas, Noffisat O Oki, Shawn Levy, Steven M Holland and Timothy R Sterling - BMC medical genetics, 11(1), 2010, pp. 37-37.
  14. In-vitro study of the host-parasite interactions between mouse macrophages and the opportunistic fungus Paecilomyces lilacinus. Peixoto E, Oliveira JC, Antas PRZ and Borba CM.Annals of Tropical Medicine and Parasitology, 104(6), 2010, pp. 529-534.
  15. Novel human genetic variants associated with extrapulmonary tuberculosis: a pilot genome wide association study. Noffisat O Oki, Alison A Motsinger-Reif, Paulo RZ Antas, Shawn Levy, Steven M Holland and Timothy R Sterling.BMC Research Notes, 4(1), 2011, pp. 28-28.
  16. Regulatory T cells phenotype in different clinical forms of Chagas' disease. de Araújo FF, Vitelli-Avelar DM, Teixeira-Carvalho A, Antas PRZ, Assis Silva Gomes J, Sathler-Avelar R, Otávio Costa Rocha M, Elói-Santos SM, Pinho RT, Correa-Oliveira R and Martins-Filho OA.PLoS Neglected Tropical Diseases, 5(5), 2011, pp. e992.
  17. Patterns of in vitro cell-death, metaloproteinase-9 and pro-inflammatory cytokines in human monocytes induced by the BCG vaccine, Moreau strain. C.J.A. Simas, D.P.H. Silva, C.G.G. Ponte, L.R.R. Castello-Branco and P.R.Z. AntasVaccine, 29(38), 2011, pp. 6446- 6450.
  18. Neglected and emerging fungal infections: review of hyalohyphomycosis by Paecilomyces lilacinus focusing in disease burden, in vitro antifungal susceptibility and management. Antas PRZ, Brito MM, Peixoto E, Ponte CG, Borba CM.Microbes and Infection, 14(1), 2012, pp. 1-8.
  19. Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases. Paulo RZ Antas, Steven M Holland and Timothy R Sterling. – Revista da Sociedade Brasileira de Medicina Tropical, 45(1), 2012, pp. 134-137.
  20. Comments on the neonatal bacillus calmette-guérin vaccination: adding notes in proof of nonspecific effect. Ponte CG, Antas PRZ, Peres LM and Marinho SP.American Journal of Respiratory and Critical Care Medicine, 187(7), 2013, pp. 778-779.
  21. A whole blood assay as a simple, broad assessment of cytokines and chemokines to evaluate human immune responses to Mycobacterium tuberculosis antigens. Dolores Silva, Carlos GG Ponte, Mariana A Hacker and Paulo RZ Antas.Acta Tropica, 127(2), 2013, pp. 75-81.
  22. Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection. Bastos ML, Menzies D, Belo MT, Teixeira EG, de Abreu ST, Antas PRZ and Trajman A.The International Journal of Tuberculosis and Lung Disease, 17(7), 2013, pp. 909-916.
  23. Detection of antibody to Purpureocillium lilacinum by immunofluorescent assay and flow cytometry in serum of infected C57BL/6 mice. Danielly C.M. de Sequeira, Mariana L.P. Peixoto, Paula M. De Luca, Joseli Oliveira-Ferreira, Paulo RZ Antas, Cintia M. Borba.Journal of Immunological Methods, 396, 2013, pp. 147-151.
  24. The Fiocruz latest contribution for understanding human tuberculosis vaccine development and its pathogenesis. Antas PRZ.Journal of Ancient Diseases & Preventive Remedies, 1, 2013, p. e107.
  25. Novel Recombinant BCG Vaccines: Do the Ordinary Platforms Matter? Antas PRZ.Journal of Ancient Diseases & Preventive Remedies, 2(1), 2014, p. 108.
  26. Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections. Rodrigues-da-Silva RN, Lima Junior JD, Fonseca BD, Antas PRZ, Baldez A, Storer FL, Santos F, Banic DM, Oliveira-Ferreira JD.Memórias do Instituto Oswaldo Cruz, April;109(2), 2014, pp. 154-162.
  27. Infection and Immunity section no. 35: A whole blood assay as a simple, broad assessment of cytokines and chemokines to evaluate human immune responses to Mycobacterium tuberculosis antigens. Dolores Silva, Carlos GG Ponte, Mariana A Hacker and Paulo RZ Antas.World Biomedical Frontiers, Apr, 2014, p. 1.
  28. Perceptions of Human Tuberculosis Vaccine: The Fiocruz Latest. Paulo RZ Antas.Clinical Journal of Vaccines and Vaccination, 1(1), 2014, p. 001.
  29. In vitro T-cell profile induced by BCG Moreau in healthy Brazilian volunteers. Ponte C, Peres L, Marinho S, Lima J, Siqueira M, Pedro T, De Luca P, Cascabulho C, Castello-Branco LR, Antas PRZ.Human Vaccines & Immunotherapeutics, 11(2), 2015, pp. 450-457.
  30. Comments on the elevated IL-27 expression in neonates: relevance between detecting nucleotide sequence or protein synthesized. Antas PRZ, Lima JR, Pedro TQ, Silva RC, Ponte CG.Immunology Letters, March;164(1), 2015, pp. 53-54.
  31. Biomarkers for the neglected Chagas disease: how remarkable! Pinho RT, Antas PRZ. - Jacobs Journal of Biomarkers, 1(1), 2015, pp. 006-010.
  32. Revisiting the current assays associated to host immune responses against tuberculosis infection. Mothe BR, Antas PRZ. - Journal of Ancient Diseases & Preventive Remedies; 3(2) 2015, pp. 123.
  33. The Brazilian Experience on BCG Immunization and the Development of New Vaccines against Tuberculosis. Antas PRZ. - SM Vaccines and Vaccination Journal, 1(1), 2015, pp. 1002.
  34. Notes for the immune responses in neonates: commonly expected dampening of the type-1 associated immunity during BCG vaccination. Antas PRZ, Lima JR, Pedro TQ, Ponte CGG. - Journal of Ancient Diseases & Preventive Remedies; 3(2) 2015, pp. 124.
  35. A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. Carpenter C, Sidney J, Kolla R, Nayak K, Tomiyama H, Tomiyama C, Padilla OA, Rozot V, Ahamed SF, Ponte C, Rolla V, Antas PRZ, Chandele A, Kenneth J, Laxmi S, Makgotlho E, Vanini V, Ippolito G, Kazanova AS, Panteleev AV, Hanekom W, Mayanja-Kizza H, Lewinsohn D, Saito M, McElrath MJ, Boom WH, Goletti D, Gilman R, Lyadova IV, Scriba TJ, Kallas EG, Murali-Krishna K, Sette A, Lindestam Arlehamn CS. - Tuberculosis (Edinb); 2015.
  36. Immunity and immune modulation in Trypanosoma cruzi infection. Cardillo F, Pinho RT, Antas PRZ, Mengel J. - Pathogens and Disease; 2015.
  37. The role of host soluble inflammatory mediators induced by the BCG vaccine for the initiation of in vitro monocyte apoptosis in healthy Brazilian volunteers. Lima J, Siqueira M, Pedro T, Ponte C, Peres L, Marinho S, Castello-Branco LR, Antas PRZ. - Journal of Inflammation (Lond); 2015.
  38. Human neonates display altered ex vivo monokine production related to healthy adults. Antas PRZ, Pedro TQ, Santiago EA, Lima JR, Silva RC, Melca LA, Ponte CG. - Immunology Letters, February;170, 2016, pp. 64-67.
  39. Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable! Pinho RT, Waghabi MC, Cardillo F, Mengel J, Antas PRZ. - Frontiers in Immunology, 7:306, 2016.
  40. Crucial requirement for standardization during the development of novel recombinant BCG vaccines: does the corresponding substrain background matter? Antas PRZ. - Human Vaccines & Immunotherapeutics, 12(12), 2016, pp. 3099-3102.
  41. The differential in vitro presentation of Mycobacterium leprae antigens by human dendritic cells is determined by the mechanism of host cell adhesion. Santos DO, Coelho JG, Neri ECL, Campos-Souza IC, Ponte CGG, Antas PRZ. - Journal of Clinical & Cellular Immunology 7, 2016, pp. 443.
  42. Experimental Hyalohyphomycosis by Purpureocillium lilacinum: Outcome of the Infection in C57BL/6 Murine Models. de Sequeira DCM, Menezes RC, Oliveira MME, Antas PRZ, De Luca PM, de Oliveira-Ferreira J, Borba CM. - Frontiers in Microbiology, 8:1617, 2017.
  43. A Pilot Study of Correlations between an IFN-Gamma ELISPOT Assay and the Tuberculin Skin Test. Antas PRZ, Silva D, Ponte CGG. - Austin Journal of Clinical Immunology 4(1), 2017, pp. 1032-1034.
  44. The patterns of in vitro cell-death and inflammatory cytokines induced by distinct BCG vaccine strains are differentially induced in human mononuclear cells. Ponte C, Hacker M, Moraes M, Castello-Branco L, Silva F, Antas PRZ. - Human Vaccines & Immunotherapeutics, 14(1), 2018, pp. 28-35.