International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.


committee

Members

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NITIN SAKSENA

Professor

1986  PhD (Microbiology) Saugar University
1982  Master of Science Saugar University
1980  Bachelor of Science Saugar University

2011  ANZ Trustees Judith Mason Foundation Award
2010  Pillar Award by Roche Australia for Hepatitis C biomarkers
2009  Strategic Funding Award (NHMRC) to develop rapid diagnostic test for resistant mutations on H1N1 2009 virus
2006  Strategic Funding Award (NHMRC) to develop rapid diagnostic test for resistant mutations on H5N1 virus
2003  Strategic Funding Award (NHMRC) to develop SARS virus diagnostic test

2013  Invited Speaker, World DNA and Genome Day, Nanjing, China
2012  Guest speaker, HIV Drug Resistance Workshop, Sydney, Australia
2011  Guest speaker, HIV Congress, Mumbai, India
2011  Invited speaker, HIV DART Conference, Kawai, Hawaii, USA
2011  Chief Guest speaker for the World AIDS day, University of Hawaii, Honolulu, USA

Books

2012 - 2013

E-Book: Current Perspectives in Non-progressive HIV disease. Frontiers in Immunology, 2013, Switzerland. Editor: Nitin K. Saksena.

Special Issues

Edited a special issue of “INFECTIOUS DISEASE REPORTS” on HIV for the world AIDS Day. Page Press, Italy. Editors: Nitin K. Saksena, Dominic E. Dwyer (Australia) and Richard Y Zhao (USA).

• Editing a special issue of MICROARRAYS on “Human diseases and genomics” due 2017 March.

1998-99

Saksena NK. Human Immunodeficiency Viruses: Biology, Immunology and Molecular Biology; 1998, Published from

Medical Systems Spa, Genoa, Italy, 700 pages. (Listed by World Health Organisation in 10 best books on HIV. See 2001-Book Review by C. Loveday In the J Antimicrobial Chemotherapy 47, 126-127.

Saksena NK. Progress and new trends in Human Immunodeficiency Virus type 1 genomics and proteomics. In Tech Publishers, Zagreb, Croatia. Due 2012 October. (In Process)

Monographs

1996

Saksena NK. Recent Advances in AIDS Research: Published by Medical Systems Apa, Italy, 110 pages. 1996

Commentaries 2015

• Do Sleeper Viruses Awaken in ALS? ALZFORUM, 23 Nov 2015

• Dementia a la Mold? Fungi May Lurk in Alzheimer’s Brains. ALZFORUM, 19 Oct 2015

• A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity. ALZFORUM, 25 Feb 2015.

Peer Reviewed Scientific Publications

2018

Wei Zhang, Xinyue Li, Longlong Wang, Jianxiang Deng, Liya Lin, Lei Tian, Jinghua Wu, Nitin K. Saksena, Huanming Yang, Jian Wang, I-Ming Wang & Xiao Liu.Identification of Variable and Joining germline genes and alleles for Rhesus macaque from B-cell receptor repertoires. Frontiers in Immunology, 2018 (In Press).

2017

• Wei Zhang,* Qiang Feng,* Changxi Wang,* Xiaojing Zeng,* Yuanping Du,* Liya Lin,* Jinghua Wu,* Longfei Fu,* Kai Yang,* Xiaoying Xu,* Hanshi Xu,* Yi Zhao,* Xue mei Li,* Ursula Huber Schoenauer,† Andreas Stadlmayr,† Nitin K. Saksena,# Herbert Tilg,‖ Christian Datz†,‡ and Xiao Liu*,‡. Characterization of BCR repertoire in the intestinal mucosa and of tumor-infiltrating lymphocytes in colorectal adenoma and carcinoma. Journal of Immunology

(2017).

2016

• Li Zhou, Lauren Fowler, and Nitin K. Saksena. Micro-RNAs and their role in HIV non-progressive disease. International Trends in Immunity, Italy Vol 4 No.1 (2-16).

• Lauren Fowler, Viviane Conceicao, Suneth S. Perera1, Priyanka Gupta, Choo Beng Chew, Wayne B. Dyer and Nitin K. Saksena. First Evidence for the Disease-Stage, Cell-Type, and Virus Specificity of microRNAs during Human Immunodeficiency Virus Type-1 Infection. In Medical Sciences (Switzerland) 4; 2 (1-34) 2016.

• Suneth Perera, Bin Wang, Arturo Damian, Wayne Dyer, Li Zhou, Viviane Conceicao and Nitin K. Saksena. Retrospective proteomic analysis of cellular immune responses and protective correlates of p24 vaccination in an HIV elite controller using antibody arrays. In Press in MICROARRAYS 2016, 5; 14 (2-19) Switzerland.

• Priyanka Gupta, Bing Liu, Jing Q. Wu, Belinda J. Goldie, Wayne B. Dyer, Dominic E. Dwyer, Adam P. Carroll, Chantel Fitzsimmons, Murray J. Cairns and Nitin K. Saksena, and. Gene-microRNA interactions in HCV-infected hepatocellular carcinoma and peripheral blood mononuclear cells are both associated with cancer pathways. In Press in MicroRNAs: Novel Biomarkers for Liver Diseases-SPECIAL ISSUE (Journal of Clinical Medicine), 2016.

• Raany Rahme, Li Zhou, Priyanka Gupta, Bin Wang, Viviane Conceicao, Murray Cairns and Nitin K. Saksena. Joint mRNA and miRNA profiling shows the first Evidence for genomic overlaps between HIV-associated Dementia (HAD) and Alzheimer1s disease. In Press in The Research for Neurodegenerative Disease"-Special Issue of journal Medical Sciences. (Basel, Switzerland) (2016).

• Wei Zhang, Qiang Feng, Changxi Wang, Xiaoying Xu, Longfei Fu, Kai Yang, Jinghua Wu, Liya Lin, Hanshi Xu, Yi Zhao, Xiaojing Zeng, Ursula Huber Schoenauer, Nitin Saksena, Herbert Tilg, Christian Datz & Xiao Liu. Characterization of BCR repertoire in intestinal mucosa and TILs in colorectal adenoma–carcinoma samples using an unbiased method. Communicated to Science Reports.

• Kabo Matlho, Xin Maggie Wang, Viviane Conceicao, Suneth S. Perera, Bin Wang, Maly Soedjono,, Monica Miranda Saksena, Dominic E. Dwyer and Nitin K. Saksena. Plasma Viremia and Non-Progressive Disease Status during HIV Infection can be predicted by the CD14+CD16-low Monocyte Subset. To Biomarkers in Medicine (2016).

2015

• Wu JQ, Saksena MM, Soriano V, Vispo E, Saksena NK. Differential regulation of cytotoxicity pathway discriminating between HIV, HCV mono- and co-infection identified by transcriptome profiling of PBMCs. Virol J. 2015 Jan 27;12:4. doi: 10.1186/s12985-014-0236-6.

2014

• Gupta P, Bing Liu, Jingqin Wu, Vincente Soriano, Eugenia Vispo, Murray J Cairns, Adam P Carroll, Belinda Goldie, Cairns MJ and Saksena NK. Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection. Virology, Virology;450-451:336-49. 2014 Feb.

• Viviane N da Conceicao, Wayne B Dyer, Kaushal Gandhi, Priyanka Gupta, and Nitin K. Saksena. Genome-wide analysis of primary peripheral blood mononuclear cells from HIV+ patients-pre-and post- HAART show immune activation and inflammation the main drivers of host gene expression. In press- Molecular and Cellular Therapies, 2014.

• Li Zhou, Lauren Fowler and Nitin K. Saksena. Micro-RNAs and their role in HIV non-progressive diseases. In Press in Frontiers in Immunology –HIV AIDS (E-Book edited by Saksena NK). 2014.

• Gupta P, Cairns MJ and Saksena NK. Gene expression and its regulation by micro-RNA in HCV infection and HCV – mediated hepatocellular carcinoma. In Press- Virology J. 11: 64, 2014.

2013

• Gupta P, Bing Liu, Jingqin Wu, Vincente Soriano, Eugenia Vispo, Murray J Cairns, Adam P Carroll, Belinda Goldie, Cairns MJ and Saksena NK. Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection. Virology (In Press), 2013.

• Fowler L and Saksena NK. "Micro-RNA: new players in HIV-pathogenesis, diagnosis, prognosis and antiviral therapy." AIDS Rev 15(1): 3-14. 2013.

Saksena NK, Conceicao V, Perera SS and Wu J (2013). "Gene array data relevant to immunological and virological monitoring of human immunodeficiency virus type 1 infection." Curr Opin HIV AIDS 8(2): 132-139.

Wu JQ, Sasse TR, Wolkenstein G, Conceicao V, Saksena MM, Soedjono M, Perera SS, Wang B, Dwyer DE, Saksena NK and Wolkenstein G (2013). "Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors." Virology 435(2): 308-319.

Ho YS and Saksena NK (2013). "Glycosylation in Envelope glycoprotein and its biological implications." Future Virology 8(8): 783-800.

Gupta P and Saksena NK (2013). "miRNAs: small molecules with big impact on HIV infection and pathogenesis." Future Virology 8(8): 769-781.

Zhou L, Saksena MM and Saksena NK (2013). "Viruses and Neurodegeneration." Virology Journal 10(172): 3-14.

Saksena NK, Dwyer DE, Zhao RY. (Editors) "Current perspectives in HIV/AIDS". Special Issue on HIV/AIDS. Infectious Disease Reports. Vol 5, No 1S (2013).

Zhou L and Saksena NK. "HIV-associated neurocognitive disorders" Special Issue on HIV/AIDS. Infectious Disease Reports. Vol 5, No 1S (2013).

Gupta P. "Hepatitis C virus and HIV type 1 co-infection". Special Issue on HIV/AIDS. Infectious Disease Reports. Vol 5, No 1S (2013).

• Jakobsen MR, Cashin K, Roche M, Sterjovski J, Ellett A, Borm K, Flynn J, Erikstrup C, Gouillou M, Gray LR, Saksena NKWang B, Purcell DF, Kallestrup P, Zinyama-Gutsire R, Gomo E, Ullum H, Ostergaard L, Lee B, Ramsland PA, Churchill MJ, Gorry PR. Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naive Subjects with Progressive HIV-1 Subtype C Infection. PLoS One. 2013 Jun 18;8(6):e65950. Print 2013.

Saksena NK. "Non-progressive HIV Disease" (e-book). Frontiers in Immunology. Frontiers Press. Switzerland. 2013.

2012

• Magdalena Czubala, Kabo Matlho, Maria Arriaga,Wayne B. Dyer, Wang B, Choo Beng Chew, Dominic E. Dwyer and Saksena NK. Title High frequency of stop codons in the HIV-1 protease gene frame in HIV+ individuals with below detectable levels of plasma viremia during HAART.. American Journal of Infectious Diseases 8 (3), 115-122, 2012.

• Li Zhou, Gulietta M. Pupo, Priyanka Gupta, Bing Liu, Sieu L. Tran, Raany Rahme, Bin Wang, Rejane Rua, Helen Rizos, Adam Carroll, Murray J. Cairns. Saksena NK. A parallel genomewide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration. BMC Genomics. 13; 677; 2012.

• Li Zhou, Viviane Conceicao, Priyanka Gupta, Saksena NK. Why are the neurodegenerative disease-related pathways overrepresented in primary HIV-infected peripheral blood mononuclear cells: A genome-wide perspective. Virology Journal. 9; 308; 2012.

• Tara Sasse, Jingqin Wu, Li Zhou and Saksena NK. Monocytes and their Role in Human Immunodeficiency Virus Pathogenesis.In American Journal of Infectious Diseases. 8 (2): 92-105. 2012.

2011

• Wang B ,Taylor J ,Ratnamohan M ,Mcphie K ,Kesson A ,Dixit R ,Booy R ,Hurt AC ,Saksena NK and Dwyer De (2012(accepted)). "Frequency of oseltamivir resistance in Sydney, during the Newcastle outbreak of community transmitted oseltamivir-resistant influenza A(H1N1)pdm09 virus, Australia. Eurosurveillance. June to August 2011.

• Gupta P, Wu JQ, Qiang L, Wong K, George J, Soriano V, Rhodes B, Wang B and Saksena NK. Parallel miRNA and mRNA profiling in HCV-infected peripheral blood cells (PBMC) and tumor/non-tumor liver tissue from patients with hepatocellular carcinoma (HCC) show correlation with cancer pathways. Global Antiviral J, Vol 7, Suppl 1, pp 73; 2011.

• Gupta P and Saksena NK. Human microRNA (hsa-miR-21): a novel marker for HIV+HCV co-infection. Global Antiviral J, Vol 7, Suppl 1, pp 122; 2011.

• Bin Wang, Dominic E Dwyer, Maly Soedjono, Haijing Shia, Kabo Matlho, Mala Ratnamohan, Christopher C Blyth, Ken McPhie, and Nitin K. Saksena. Cluster cases of Influenza A (H1N1) D222D/G/N/S haemagglutinin mutants during 2009 influenza pandemic. J Clin Virol. 2011 Dec;52(4):304-6

• Li Zhou, Gulietta M. Pupo, Sieu L Tran, Bin Wang, Rejane Rua, Helen Rizos, Thomas Ng, Nitin K. Saksena. Genome-wide expression profiles in the frontal cortex of HIV patients with and without HIV-associated dementia (HAD) Mol Neurodegeneration. 2010 Jun 24;5:27. doi: 10.1186/1750-1326-5-27.

• Wu JQ, Dominic E. Dwyer, Wayne B Dyer, Yee Hwa Yang, Bin Wang, and Saksena NK. Genome-wide analysis of primary T cell (CD4+ and CD8) transcriptomes show Evidence for a network of enriched pathways associated with HIV disease. Retrovirology. Mar 16;8:18. doi: 10.1186/1742-4690-8-18, 2011.

• Wang B, Steain MC, Dwyer DE, Cunningham AL, Saksena NK. Synthetic long oligonucleotides to generate artificial templates for use as positive controls in molecular assays: drug resistance mutations in influenza virus as an example. Virol J. 8:405 2011.

2010

Saksena NK, Bin Wang, Li Zhou, Maly Soedjono, Yung Shwen Ho and Viviane Conceicao. HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites. Journal of HIV and Palliative care, Dove Press. 2; 103-

122: 2010.

• Lau KA, Bin Wang, Monica Miranda-Saksena, Ross Boadle, Adeeba Kamarulzaman, Kee-Peng Ng and Nitin K. SaksenaEvidence for possible biological advantages of the newly emerging HIV-1 circulating recombinant form (CRF) from Malaysia − CRF33_01B in comparison to its progenitors− CRF01_AE and subtype B. In Press- Current HIV Research, USA. Apr 1;8(3):259-71. 2010.

• Wightman F, Ajantha Solomon, Gabriela Khoury, Justin Green, Lachlan Gray, Paul R Gorry, Nitin K. Saksena, Yung Shwen Ho, Jennifer Hoy, Suzanne M Crowe, Paul U Cameron Sharon R Lewin. Both CD31-positive and CD31-negative naive CD4 T-cells are persistent HIV-infected reservoirs in individuals receiving antiretroviral therapy. Journal of Infectious Diseases Dec 1;202(11):1738-48. 2010.

• Zhou L, Eve Diefenbach, Ben Crossett, Rejane Rua, Bin Wang, Amit Kapur, Bruce J. Brew and Nitin K. Saksena. First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: Proteomic analysis of the frontal cortex from HIV+ patients with and without dementia. Molecular Neurodegeneration Jun 24;5:27. 2010.

• Zhou L, Rua R, Ng T, Vongrad V, Ho YS, Geczy C, Hsu K, Brew BJ, Saksena NK.

• Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia. BMC Infect Diseases. ;2; 9:192. 2010.

• Wade J, Sterjovski J, Gray L, Roche M, Chiavaroli L, Ellett A, Jakobsen MR, Cowley D, Pereira Cda F, Saksena NK, Wang B, Purcell DF, Karlsson I, Fenyo EM, Churchill M, Gorry PR. Enhanced CD4+ cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection. Virology. 2010 Jan 20;396(2):246-55.

• Yoo P, Ho YS, Ng, J, Charleston M, Saksena NK, Yang P and Zomaya AY. Hierarchical Kernel mixture models for the prediction of AIDS disease progression using HIV structural gp120 profiles. BMC Genomics 11 (suppl): S22; 1-10. 2010.

• Wang B, Dwyer DE, Blyth CC, Soedjono M, Shi H, Kesson A, Ratnamohan M, McPhie K, Cunningham AL, Saksena NKDetection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections. Antiviral Res.Jul;87(1):16-21. 2010.

2009

• Gray, L., M. Roche, M. J. Churchill, J. Sterjovski, A. Ellett, P. Poumbourios, S. Sherieff, B. Wang, NK. Saksena, D. F. Purcell, S. Wesselingh, A. L. Cunningham, B. J. Brew, D. Gabuzda and P. R. Gorry (2009). "Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain." J Virol 83(11): 5430-5441.

Saksena, NK., J. Q. Wu, K. A. Lau, L. Zhou, M. Soedjono and B. Wang. CD8 Antiviral Soluble Factors and Human Immunodefieciency Virus (HIV) Control. M. A. Ph.D, Bentham Books (Bentam Science Publishers): 11-34.2009

• Steain, M. C., D. E. Dwyer, A. C. Hurt, C. Kol, N. K. Saksena, A. L. Cunningham and B. Wang (2009). "Detection of influenza A H1N1 and H3N2 mutations conferring resistance to oseltamivir using rolling circle amplification." Antiviral Res 84(3): 242-248.

• van Hal, S. J., B. Herring, Z. Deris, B. Wang, N. K. Saksena and D. E. Dwyer (2009). "HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure." Retrovirology 6: 12.

• Wang, B., D. E. Dwyer, C. B. Chew, C. Kol, Z. P. He, H. Joshi, M. C. Steain, A. L. Cunningham and N. K. Saksena (2009). "Sensitive detection of the K103N non-nucleoside reverse transcriptase inhibitor resistance mutation in treatmentnaive HIV-1 infected individuals by rolling circle amplification." J Virol Methods 161(1): 128-135.

2008

• Wu JQ, Wang B, Saksena NK. Transitory viremic surges in an HIV+ elite controller can shift cellular transcriptome profile: a word of caution for microarray studies. J Virol. 2008 Aug 13. [Epub ahead of print] PMID: 18701597.

• Wu JQ, Dwyer DE, Dyer WB, Yang YH, Wang B, Saksena NK. Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses. Virology. 2008Aug 8. [Epub ahead of print] PMID: 18692859.

• Caly L, Saksena NK, Piller SC, Jans DA. Impaired nuclear import and viral incorporation of Vpr derived from a HIV longterm non-progressor. Retrovirology. 2008 Jul 18;5:67.

• Zhou L, Ng T, Yuksel A, Wang B, Dwyer DE and Saksena NK: Absence of HIV infection in the choroid plexus of two patients who died rapidly with HIV-associated dementia. AIDS Research & Human Retroviruses, 24(6): 839-843. 2008.

• Lau KA Bin Wang, Adeeba Kamarulzaman, Kee-Peng Ng and Nitin K. Saksena.Continuous crossover(s) events of HIV-1 CRF01_AE and B subtype strains in Malaysia: Evidence of Rapid and Extensive HIV-1 Evolution in the Region. Current HIV Research, 6(2) 108-16; 2008.

• Fujii YR and Saksena NK:”RNA and the Regulation of Gene Expression” (Book Chapter) in “RNA and the Regulation of Gene Expression: A Hidden Layer of Complexity”, Publisher: Horizon Scientific Press; Editor: Kevin V. Morris, The Scripps Research Institute, 10550 N. Terrey Pines Road, La Jolla, CA, 92037. 2008 (In press, January 1, 2008). ISBN 1904455255, 9781904455257; 228 pages.

Saksena NK, Wu JQ, Potter SJ, Wilkinson J and Wang B. HIV interaction with the CD8+ T cells. Current HIV Research (Peer Reviewed) 6(1); 1-9: 2008.

• Ho YS, Abecasis AB, Theys K, Deforche K, Dwyer DE, Charleston M, Vandamme AM, Saksena NK.HIV-1 gp120 N-linked

glycosylation differs between plasma and leukocyte compartments. Virol J. 2008 Jan 23;5(1):14 [Epub ahead of print].

• Steain MC, Wang B and Saksena NK. The possible contribution of HIV-induced syncytia to the generation of intersubtype recombinants in vitro. AIDS, 22(9)1009-17; 2008).

• Jing Qin Wu, Wayne B. Dyer, Jeremy Chrisp, Larissa Belov, Bin Wang and Nitin K. Saksena. Longitudinal Microarray Analysis of Cell Surface Antigens on Peripheral Blood Mononuclear Cells from HIV+ Individuals on Highly Active Antiretroviral Therapy. Retrovirology, 5: 24 2008.

2007

Saksena NK, Rhodes B, Wang B and Soriano V. Elite HIV controllers: Myth or a reality. (Review) AIDS Reviews 9: 195- 207: 2007.

• Lau KA, Wang B and Saksena NK. Emerging trends of HIV epidemiology in Asia. (Review) AIDS Reviews 9; 218-229: 2007

• Lau K, Wang B, Kamarulzaman A, Ng KP, and Saksena NK. Near full-length sequence analysis of HIV-1 CRF33_01B/B Intersubtype recombinant from Malaysia: Evidence of secondary recombinant derived from CRF33_01B. AIDS

Research & Human Retroviruses 23, 1139-1143; 2007.

• Wang YM, Wang B, Dyer WB, Lachireddy K, Peng NG and Saksena NK. Evidence for predominance of CCR5-using HIV-1 strains during HAART. Current HIV Research 5, 221-234, 2007.

• Wang YM, Dyer WB, Workman, C, Wang B, Ng KP, Lachireddy K, Chew CB, Sullivan J and Saksena NK. Drug resistance and viral evolution in plasma and peripheral blood cells during structured treatment interruption (STI) and noninterrupted HAART. Current HIV Research 2, 235-250, 2007.

• Wang B, Lau KA, Ong LY, Shah M, Steain MC, Foley B, Dwyer DE, Chew CB, Kamarulzaman A, Ng KP and Saksena NKComplex patterns of the HIV-1 epidemic in Kuala Lumpur, Malaysia: Evidence for expansion of circulating recombinant form CRF33_01B and detection of multiple other recombinants. Virology 367, 388-397; 2007.

• Sterjovski J, Churchill MJ, Ellett A, Gray LR, Roche MJ, Dunfee RL, Purcell DF, Saksena N, Wang B, Sonza S, Wesselingh SL, Karlsson I, Fenyo EM, Gabuzda D, Cunningham AL, Gorry PR. Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS. Retrovirology. Dec 12;4(1):89 [Epub ahead of print] 2007.

• Wu JQ, Wang B, Belov L, Chrisp J, Learmont J, Dyer WB, Zaunders J, Cunningham AL, Dwyer DE, Saksena NK. Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages. Retrovirology. Nov 26;4(1):83 [Epub ahead of print] 2007.

• Sivakumaran H, Wang B, Gill MJ, Beckholdt B, Saksena NK, Harrich D. Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort. Virology J. Oct 25;4(1):107 [Epub ahead of print] 2007.

2006

• Arriaga ME, Jillian Carr, Peng Li and Saksena NK. Interaction between HIV-1 and APOBEC3 sub-family of proteins. Current HIV Research. 4, 401-401; 2006.

• Hales G, et al., and the CREST STUDY GROUP FOR HIV DRUG RESISTANCE (includes Saksena NK). A randomized trial comparing genotypic and virtual phenotypic interpretation of HIV Drug Resistance: The CREST study. PLOS Clinical Trials July e18; 1-9, 2006.

• Steain MC, Wang B and Saksena NK. Analysis of HIV-1 sequences vertically transmitted to infants in Kisumu, Kenya. Journal of Clinical Virology, 36(4)298-302: 2006.

• Potter SJ, Lemey P, Dyer WB, Sullivan JS, Chew CB, Vandamme AM, Dwyer DE, Saksena NK. Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAART. Virology, 348(1) 35-46: 2006.

• Verity EE, Williams LA, Haddad DN, Choy V, O'Loughlin C, Chatfield C, Saksena NK, Cunningham A, Gelder F, McPhee DA. Broad neutralization and complement-mediated lysis of HIV-1 by PEHRG214, a novel caprine anti-HIV-1 polyclonal antibody. AIDS, 28;20(4):505-15: 2006.

• Shah M, Smit TK, Morgello S, Tourtellotte W, Gelman B, Brew BJ, Saksena NK. Env gp120 sequence analysis of HIV type 1 strains from diverse areas of the brain shows preponderance of CCR5 usage. AIDS Res Hum Retroviruses, 22(2):177-81.

• Gray L, Churchill MJ, Keane N, Sterjovski J, Ellett AM, Purcell DF, Poumbourios P, Kol C, Wang B, Saksena NKWesselingh SL, Price P, French M, Gabuzda D, Gorry PR. Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele.J Virol, 80 (7):3684-91: 2006.

2005

Saksena NK, Wang B, Steain M, Yang RG and Zhang LQ. Snapshot of HIV pathogenesis in China. Cell Research (Nature Group of publications), 15 (11-12): 953-961. 2005.

Saksena NK and Smit TK. HIV-1 neuropathogenesis in the era of HAART. Indian Journal of Medical Research, 121 (4) 256-69: 2005.

• Cali L.Wang B, Mikhail M, Gill MJ, Becthold B, Salemi M, Jans DA, Piller SC, and Saksena NK. Evidence for HostDriven Selection of the HIV-1 vpr Gene in vivo During HIV Disease Progression in a Transfusion Acquired Cohort.
AIDS Research & Human Retroviruses, 21(8) 728-33: 2005.

• Choo Beng Chew, Simon J Potter, Bin Wang, Yuan Min Wang, Chanh Op Shaw, Dominic E Dwyer, Nitin K Saksena. Assessment of Drug Resistance Mutations in Plasma and Peripheral Blood Mononuclear Cells at Different Plasma Viral Loads in Patients Receiving HAART. J. Clin Virology, 33(3) 206-16: 2005.

• Steain MC, Wang B, Yang C, Li M, Nahlen B, Lal RB and Saksena NK. HIV-1 sequence diversity and dual infections in Kisumu, Kenya. AIDS Research & human Retroviruses, 10; 882-5: 2005.

• Wang B, Potter SJ, Lin Y, Cunningham AL, Dwyer DE, Su Y, Ma X, Hou Y and Saksena NK. An approach to rapid and sensitive detection of SARS coronavirus (SARS-CoV) using Rolling Circle Amplification. J. Clin Microbiology, (3);

206-16: 2005.

• Mikhail M, Wang B, Lemey P, Beckthold B, Vandamme AM, Gill JM and Saksena NK. Longitudinal analysis of Fulllength HIV genomes demonstrating transmission of HIV-1 from a non-progressing donor to two recipients who progressed to AIDS. AIDS Res & Human Retroviruses, (6): 575-9: 2005.

• Mikhail M, Bin Wang, Lemey P, Beckholdt B, Vandamme AM, Gill MJ, and Saksena NK. Role of viral evolutionary rate in HIV disease progression in a linked cohort. Retrovirology, June 29; 2 41-50: 2005.

• Wang B, Potter SJ, Lin Y, Cunningham AL, Dwyer DE, Su Y, Ma X, Hou Y and Saksena N. Early and sensitive detection of SARS coronavirus (SARS-CoV) using Rolling Circle Amplification. J. Clin Microbiology, (3); 206-16:

2005.

2004

Saksena NK. TRIM5alpha and HIV-1 resistance in monkeys: Innate immunity to retroviruses. ASHM Journal Club 13 (6); December 2004.

• Steain MC, Wang B, Dwyer DE and Saksena NK. HIV-1 coinfection, superinfection and recombination. Sexual Health, 1, 239-250; 2004 (Peer Reviewed).

• Potter SJ, Chew CB, Steain M and Saksena NK. Obstacles in successful antiretroviral treatment: Problems and perspectives. Indian Journal of Medical Research, 119, 217-237; 2004.

• Smit TK, Brew BJ, Tourtellotte W, Morgello S, Gelman BB and Saksena NK. Evidence of independent evolution of HIV drug resistance in diverse areas of the brain in HIV-infected patients with and without dementia on HAART. J. Virology, 78 (18), 10133-48, 2004.

• Zaunders J, Dyer WB, Wang B, Munier ML, Saksena MM, Newton R, Moore J, Mackay C, Cooper DA, Saksena NK and Kelleher AD. Identification of circulating antigen specific CD4+T lymphocytes with a CCR5+ cytotoxic phenotype in an HIV-1 LTNPs and in CMV infection. Blood, 10.1182, March 2004.

• Otake K, Omoto S, Yamamoto T, Okuyama H, Okada H, Okada N, Kawai M, Saksena NK and Fujii YR. HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferatoractivated receptors. AIDS. 18; 1-10, 2004.

• Mikhail M, Wang B and Saksena NK. Mechanisms involved in non-progressive HIV disease. AIDS Reviews 5, 230-244: 2004 January.

• Shinya Omoto, Masafumi Ito , Yutaka Tsutsumi , Yuko Ichikawa , Harumi Okuyama, Ebiamadon Andi Brisibe , Nitin K Saksena and Yoichi R Fujii. HIV-1 nef suppression by virally encoded microRNA. Retrovirology 1:44: 2004. (70

Citations).

2003

• Herring BL, Ge YC, Wang B, Ratnamohan M, Zheng F, Cunningham AL, Saksena NK and Dwyer DE. Segregation of HIV-1 subtypes by risk factor in Australia. J. Clin Microbiology. 41(10), 4600-4604: 2003.

Saksena NK and Haddad DN. Viral reservoirs an impediment to HAART: New strategies to eliminate HIV-1. Current Drug Target-Infectious Diseases, USA. 3, 179-206: 2003

• Wang B, Mikhail M, Dyer WB, Zaunders JJ, Kelleher AD and Saksena NK. First demonstration of a lack of sequence evolution in a non-progressor, defining replication-incompetent HIV-1 infection. Virology. 312; 135-

150: 2003.

Saksena NK and Potter SJ. Reservoirs of HIV-1 in vivo: Implications for antiretroviral therapy. AIDS Reviews. 5; 3-18: 2003.

• Lemey P, Pybus OG, Wang B, Saksena NK and Vandamme AM. Tracing the origin and history of HIV-2 epidemic. Proceedings of National Academy of Sciences (PNAS), USA. 100, 6588-6592: 2003. (114 citations)

• Lemey P, salemi M, Wang B, Saksena NK, Vandamme A: Maximum likelihood analysis of clock-like behaviour of HIV: Implications on dating strategies in HIV molecular phylogenies. In Press. Journal of Molecular Evolution.

2003.

• Potter SJ, Dwyer DE and Saksena NK. Differential cellular distribution of HIV drug resistance in vivo: Evidence for infection of CD8 T cells during HAART. Virology, 305; 339-352 December 2003.

• French M, Amin J, Roth N, Carr A, Law M, Emery S, Drummond F, Cooper D on behalf of OzCombo 2 investigatorsA randomised, open label, comparative trial to evaluate the efficacy and safety of three antiretroviral drug combinations including two nucleoside analogues and nevirapine for previously untreated HIV-1 infection: the OzCombo 2 study. HIV Clinical Trials 3:177-185, 2002.

• Amin J, Moore A, Carr A, French MA, Law M, Emery S, Cooper DA on behalf of the Ozcombo 1 and 2 investigators. Combined analysis of two year follow-up from two open-label randomised trials comparing efficacy of three nucleoside reverse transcriptase inhibitor backbones for previously untreated HIV-1 infection. HIV Clinical Trials 4:252-261, 2003.

2002

• Dwyer DE, Herring BL and Saksena NK: The significance of HIV genetic variability for the clinician. In CPD Infection (U.K), 3(3), 95-99; 2002.

• .Zhao Y, Chen M, Wang B, Yang J, Elder RT, Song X, Yu M and Saksena NK. Functional conservation of HIV-1 Vpr and variability in mother-child pair of long-term non-progressors. Virus Research 89; 1-19, 2002.

• Masciotora S, Owen SM, Rudolph D, Yang C, Wang B, Saksena N, Spira T, Dhawan S and Lal RB: Temporal relationship between V1-V2 variation, macrophage replication and co-receptor adaptation during HIV disease progression. AIDS 16: 1887-1898; 2002.

• Yamamoto T, Omoto S, Mizuguchi M, Mizukami H, Okuyama H, Okada N, Saksena N et al. Double stranded nef interferes with HIV replication. Microbiology and Immunology, 46 (11) 809-817, November 2002.

Saksena NK: Mechanisms in non-progressive HIV disease: World Courier Journal July 25, 2002.

• Wang B, BW Dyer, JJ Zaunders, JS Sullivan, G Harris. JAG Holt, LD Cooper, and NK Saksena. Comprehensive analyses of a unique HIV-1-infected non-progressor reveal novel biological, molecular and immunological mechanisms suppressing viral replication in vivo. Virology. 304; 246-264; 2002.

2001

• Birch MR, Learmont JC, Dyer WB, Deacon NJ, Zaunders JJ, Saksena NK, Cunningham AL, Mills J and Sullivan JS. An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC). J. Clin Microbiol. 22(3); 263-70. 2001.

• Herring B, Saksena NK and Dwyer DE: Molecular classification of HIV viruses. Microbiology Australia, 2001.

• Dwyer DE, Birch C, and Saksena NK: Laboratory Testing for anti-retroviral drug resistance. Microbiology Australia,2001.

Saksena NK, Dyer WB and Wang B. Biological and Molecular Mechanisms in progression and non-progression of HIV disease. AIDS REVIEWS. 13, 133-144, 2001.

• Halani N, B Wang B, YC Ge, H Gharpure, S Hira S, and NK Saksena. Changing Epidemiology of HIV-1 Infection in India: Evidence of subtype B introduction of Bombay from a Common Source. AIDS Res Hum Retroviruses, vol 17, number 7, 637-642; 2001.

• Smit TK, B Wang, T Ng, R Osborne, B Brew, NK Saksena. Varied Tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC) evidence for neurotropic HIV-1 variants. Virology 279; 509-30; 2001.

2000

• Wang, YM, WB.Dyer, C Workman, B Wang, JS Sullivan, NK Saksena. Molecular evidence for drug-induced compartmentalization of HIV-1 quasispecies in a patient with periodic changes to HARRT. AIDS :14: 2265-2272:2000.

• Wang B, RB Lal, DE Dwyer, M Mirand-Saksena, R Boadle, AL Cunningham, NK Saksena. Molecular and biological interaction between two HIV-1 strains from a co-infected patient reveal the first evidence in favour of viral synergism. Virology 274; 105-119: 2000.

• Wang B, TJ Spira, S Owen, RB Lal, NK Saksena. Longitudinal analyses of HIV-1 quasispecies in a cohort of American patients with different disease progression rates: exclusive presence of extended V2 region in slow and long-term no-progressors. AIDS; 14: 213-223: 2000.

• Haddad DN, Birch C, Middleton T, Dwyer DE, Cunningham AL and NK Saksena. Evidence for late stage compartmentalization of HIV-1 resistance mutations between lymphnodes and PBMC. AIDS, 14: 2273-2281;2000.

1999

• Chew BC, BL Herring, F Zheng, C Browne, NK Saksena, AL Cunningham, DE Dwyer. Comparison of three commercial assays for the quantification of HIV-1 RNA in plasma from individuals infected with different HIV-1subtypes. J Clin Virology 14:87-94, 1999.

• Bolton WV, AR Davis, YC Ge, DE Dwyer, KG Kenrick, AL Cunningham, NK Saksena. Molecular evidence for transmission of HTLV-II infection by a human bite. J Clin Microbiol 37:238-240, 1999.

• Song JZ, B Wang, YC Ge, DE Dwyer, AL Cunningham, NK Saksena. Significance of plasma and peripheral blood mononuclear cell derived HIV-1 sequences in establishing epidemiologic linkage between two individuals exposed to HIV-1. Microbial Pathogenesis;26:287-298: 1999.

Saksena NK, B Wang, FJ Novembre, W Bolton, TK Smit, RB Lal. Species-specific changes in i the CCR5 gene from African and Asian nonhuman primates. AIDS Res Hum Retrovir. 15:479-483: 1999.

1998

• Dwyer D, B Herring, YC Ge, W Bolton, RB Ellis-Pegler, M Thomas, BA Schroeder, MC Croxson, JI Mullins, NK Saksena. Human immunodeficiency virus type 1 subtypes B and C detected in New Zealand. AIDS Res Hum Retrovir 14:1101-1105, 1998.

• Wang B, R Jozwiak, YC Ge, NK Saksena. A unique naturally occurring single amino acid mutation in HIV-1 V3 loop can discriminate between its cytopathicity and replication in vivo and in vitro. AIDS Res Hum Retrovir 14:1019-1021, 1998.

Saksena NK, R Jozwiak, B Wang. Molecular and biological mechanisms in the development of AIDS dementia complex (ADC). Res Inf Dis, Bull Institut Pasteur 96:2-18, 1998.

• Chang J, R Jozwiak, B Wang, T Ng, YC Ge, W Bolton, DE Dwyer, C Randle, R Osborn, NK Saksena. Unique HIV type 1 V3 regions sequences from six different regions of the brain: region-specific evolution within host determined quasispecies. AIDS Res Hum Retrovir; 14:25-30. 1998.

1997

• Cunningham AL, H Naif, NK Saksena et al. HIV infection of macrophages and pathogenesis of AIDS dementia complex: interaction of the host cell and viral phenotype. J Leukocyte Biol 62: 117-125, 1997.

• Wang B, P Palasanthiran, J Ziegler, AL Cunningham, NK Saksena. CCR5 and HIV disease progression. Lancet 350:742, 1997.

Saksena NK, YC Ge, B Wang, SH Xiang, J Ziegler, P Palasanthiran, W Bolton, AL Cunnningham. RNA and DNA sequence analysis of the nef gene of HIV-1 strains from the first HIV-1 infected long-term non-progressing mother-child pair. AIDS Res Hum Retrovir 13:425-430, 1997.

Saksena NK, YC Ge, B Wang, SH Xiang, J Ziegler, P Palasanthiran, W Bolton and AL Cunningham. RNA and DNA sequence analysis of the nef gene of HIV-1 strains from the first HIV-1 infected long-term non-progressing mother-child pair. AIDS Research and Human Retroviruses, 13, 729-732; 1997.

• B Wang, YC Ge, R Jozwiak, W Bolton, P Palasanthiran, J Ziegler, J Chang, SH Xiang, AL Cunningham and Saksena NK. In press Molecular analyses of HIV-1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term non-progressing mother and child pair. Journal of Inf Diseases, 175:1510-1515: 1997.

Saksena NK, B Wang, YC Ge, SH Xiang, DE Dwyer and AL Cunningham Coinfection and genetic recombination between HIV-1 strains: possible biological implications in Australia and South East Asia. Annals Academy of Medicine, 26, 1-8, 1997.

• DE Dwyer, YC Ge, B Wang, WV Bolton, JG McCormack, AL Cunningham and Saksena NK. First human immunodeficiency virus type 1 sequences in the V3 region, nef and vpr genes from Papua New Guinea. AIDS Research and Human Retroviruses,13, 625-627, 1997

• B Wang, YC Ge, P Palasanthiran, J Ziegler, W Bolton, SH Xiang, DE Dwyer, AL Cunningham and Saksena NK. HIV type1 V3 loop sequences derived from peripheral blood of transmitting mothers, their infants, and nontransmitting mothers differ in their crown octapeptide motifs. AIDS Research and Human Retroviruses, 13, 275-279, 1997.

Saksena NK, B Wang, YC Ge, J Chang, DE Dwyer, SH Xiang, DR Packham, C Randle and AL Cunningham. Regionspecific changes, gene duplications, and random deletions in the nef gene from HIV-1 infected brain tissues and blood of a demented patient. AIDS Research and Human Retroviruses, 13, 111-116, 1997.

1996

Saksena NK, YC Ge, B Wang, SH Xiang, DE Dwyer, C Randle, P. Palasanthiran, J. Ziegler, and AL Cunningham. An HIV-1 Infected Long-term Non-progressor (LTNP): Molecular Analysis of HIV-1 Strains in the vpr and nef Genes. Academy of Medicine,. 25, No.6, 848-854, 1996.

Saksena NK, A Srinivasan, YC Ge, SH Xiang, A Azad, W Bolton, V Herve, S Reddy, O Diop, MM Saksena, WD Rawlinson, AM Vandamme and FB Sinoussi. Simian T-cell leukaemia virus type-1(STLV-1) from naturally infected feral monkeys from Central and West Africa encode a 91-amino acids p12 (ORF-1) protein as opposed to a 99 amino acids protein encode by HTLV type 1 from humans. AIDS Research and Human Retroviruses, 13, 225-232,1996.

• B Wang, YC Ge, P. Palasanthiran, SH Xiang, J. Ziegler, DE Dwyer, C. Randle, D. Dowton, AL Cunningham and Saksena NK. Gene defects clustered at the C-terminus of the vpr gene of HIV-1 in long-term nonprogressing mother and child pair: in vivo evolution of vpr quasispecies in blood and plasma. Virology. 223, 224-232, 1996.(170 citations)

• Holland D, Dwyer DE, Saksena NK, Naif H, and Cunningham AL Dementia, pancytopenia and death from AIDS within one year of primary HIV infection. Clinical Infectious Diseases 2. 651-2; 1996.

Saksena NK. Global Dissemination and evolution of Human and Simian T-Cell leukaemia viruses type-1 and 2. Venerealogy. 21; 1-8; 1996.

• Ge YC, Wang B, Dwyer DE, Xiang S, Cunningham AL and Saksena NK Length polymorphism in the viral protein R (vpr) gene of Human immunodeficiency virus type 1 (HIV-1).12 (4) 351-354, 1996 AIDS Res Human Retroviruses.1996.

• Dwyer DE, Ge YC, Bolton WV, Wang B, Cunningham AL and Saksena NK Subtype B isolates of Humanimmunodeficiency virus type-1 detected in Australia.. AIDS Res and Human Retroviruses, 21, 31-35; 1996.

• Dwyer DE and Saksena NK Subtypes of HIV in Australia. Australian HIV surveillance report. Vol 12, No. 1: 1-6.1996.

1995

Saksena NK et al. Sequence analysis of Simian T Cell Lymphoma/Leukaemia Virus type 1 from naturally infected monkeys from Central and West Africa reveals evolutionary conservation of immunogenic and neutralizing domains of gp46 surface membrane protein. AIDS Res. Hum Retroviruses. 11, 1265-1267, 1995.

• Bolton, WV, Kenrick, KG, Dwyer, DE, Cunningham AL, and Saksena NK Partial Nucleotide Sequence Analysis of the first case of HTLV-2 from Australia. AIDS Res Hum Retroviruses. 11, 765-767, 1995.

1994

• Dube DK, Saksena NK, Enensoy S, Jones B, Bryz Gornia V, Spicer T. Love JL,.) and Poiesz; et al Serological and nucleic acid analyses for HIV and HTLV infection on Archival human plasma samples from Zaire Virology. 273; 13-23. 1994

• Dube DK, Dube S, Sherman MP, Saksena NK et al Estimation of Genetic Heterogeneity in Primate T-cellLymphoma/Leukaemia Viruses by PCR.. In Methods in Neuroscience: PCR neuroscience ed. (Sarkar G.) Academic Press. 22: 92-109. 1994.

1993

• Dube DK, Sherman MP, Saksena NK, Bryz Gornia V, Mendelson J, love J, Arnold CB, Spicer T, Dube S, Glaser JB, Williams AE, Nishimura M, Jacobsen S, Ferrer JF, Pino N, Guiruelas S and Poiesz BJ Genetic heterogenity in human T-cell leukaemia/Lymphoma virus type II. J. Virology, 67, 1175-1184. 1993.

• Sherman MP, Dube DK, Saksena NK and Polesz BJ. Human T-cell lymphoma/leukaemia retroviruses and Malignancy. In leukaemia. Advances in Research and Treatment Chapter V, 1993.

• Poiesz BJ, Saksena NK, Dube DK, Gavalchin J, Fan N, Lane M and Paul B The biology and epidemiology of the Human T-Cell Lymphoma/Leukaemia Viruses. In the proceedings of the frontiers of infectious diseases. 1993.

Saksena NK, Herve V, Sherman MP, Durand JP, Mathiot C, Muller M, Love JL, Le Guenno B, Barre-Sinoussi F, Dube DK and Polesz BJ. Sequence and phylogenetic analyses of a new STLV-1 from a naturally infected tantalus monkey from Central Africa. Virology, 192, 312-320; 1993.

Saksena NK and Truffaut N. Identification of the product of tetp gene: A possible mechanistic basis for tetracycline resistance in C. perfringens. Folia Microbiologica; 38, 120-129; 1993.

1992

• Sherman MP, Saksena NK, Dube DK, Yanaglhara R and Polesz BJ. Evolutionary insights on the origin of human Tcell lymphoma/leukaemia virus type1 (HTLV-1) derived from sequence analysis of new HTLV-1 variant from Papua New Guinea. Journal of Virology, 66; 2556-2563, 1992.

• Dwyer DE and Saksena NK. Failure of ultra-violet irradiation and autoclaving to eliminate PCR contamination. Molecular and cellular probes, 6, 87-88m 1992.

Saksena NK, Dwyer DE, Muller M, Durand JP, Herve V, Lang MC, and Barre Sinoussi F. PCR amplification of large genomic fragments from human and simian immunodeficiency virus infected cell lines. Life Sciences, 50, 1973-1984, 1992.

• Sherman MP, Dube DK, Saksena NK, and Poiesz BJ . Non-AIDS human retrovirus infection. Canadian Pedriatic Society, 20. 1992

Saksena NK, Sherman MP, Yanagihara R, Dube DK and Polesz BJ. LTR sequence and phylogentic analyses of a newly discovered variant of HTLV-1 isolated from the hagahai of Papua New Guinea. Virology, 189, 1-9; 1992.

• Muller M, Saksena NK, Nerrienet E, Chappey C, Herve V, Durand JP, Barre-Sinoussi F, Campodonico PL, Lang MC, Digoutte JP, Georges AJ, Georges Courbot MC, Sonigo P and Barre-sinoussi F. Simian immunodeficiency viruses from Central and Western Africa: Evidence for a new species specific lentivirus in Tantalus monkey. Journal of Virology, 164, 1261-1270, 1992.

Saksena NK and Truffaut N. Cloning of tetracycline resistance from various strains of clostridium perfringens and expression in E. Coli. Can.J. of Microbiology, 38; 215-221, 1992.

1991

Saksena NK, Dwyer DE, and Barre-Sinoussi F.A sentinel technique for monitoring viral aerosol contamination. Journal of infectious diseases, 164; 1021-2, 1991.

1980-1987 (Publications during my Bachelor of Science and Master of Science) PLANT SCIENCES

Saksena NK Fungicidal action and structure correlation of monosubstituted phenyl-isothiocyanates, Folia Microbiologica (Czechoslovakia), 30, 359-362, 1985.

Saksena NK, et al., Cationic degradation of streptomycin and Kanamycin by Aspergillus niger in broth cultures during fermentation in shake flasks: Hindustan Antibiotics (Idia), Vol 26, No 3-4, 1984.

Saksena NK & H.H.S. Tripathi, Plant volatiles in relation to fungistasis:, Fitoterapia (Italy), vol LVI, 4, 1985.

Saksena NK & H.H.S. Tripathi, Effects of organic volatiles from saccharomyces on the spore germination of fungi: Acta Microb Hung (Hungary), 34, (3-4) 255-257, 1987.

Saksena NK, et al.Complete control of P. parasitica var. Piperina by 5-fluorocytosine:, Phytophthora Newsletter (France), Nov., N°13, 32-33, 1985.

Saksena NK, et al., Efficacity of Hydroxystilbamidine isothionate USP against P. parasitica var. piperina: Phytophyhora Newsletter (France), Nov, N° 13, 30-31, 1985.

Saksena NK & S. Saksena, Enhancement in the antifungal activity of some essential oils in combination against some dermatophytes Indian Perfumer, 28 (1), 42-45, 1984.

Saksena NK, Comparative evaluation of some essential oils for their antifungal activity against some dermatophytes: Indian Perfumer, 28 (1), 35-37, 1984.

Saksena NK et al., Post-harvest accumulation of vitamin C induced by Bacillus fructodestruens in L. esculentum fruits Nat. Acad Sci Lett., (7), 4, 1984.

Saksena NK et al., Decline in the total reducing sugar content during the post harvest infection of L. lycopersicum (L) Karsten fruits by B. fructodestruens: Bull of Bot. Soc., 30-31, pp. 69-71, 1984.