International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.


committee

Members

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SISTO MARGHERITA

Professor

  • Pathophysiology and molecular immunology applied to immunological research lines.
  • Molecular processes underlying the interaction between receptors of the immune response, inflammation and characterization of new anti-inflammatory molecules.
  • Novel therapies for Sjögren’s syndrome autoimmune disease.
  • Evaluation of the pathogenic role of autoantibodies produced in the course of autoimmune diseases.
  • Molecular analysis of transmembrane receptors involved in the penetration of autoantibodies in the target cells and study of the transductional mechanisms triggered by autoantibodies uptake.
  • neovascolarization associated to cancer progression
  • Understanding the molecular basis of immune regulation in autoimmunity.
  • Dysregulation of immunological responses during the pathogenesis of chronic inflammatory diseases.
  • Study of emerging avenues linking inflammation, angiogenesis and autoimmune disorders.

 

2011 Winner of MD Honors Research Award (10.000 $) for the project “ The NF-kB Pathway as a Potential Target for Autoimmune Disease Therapy”.

Spanish National Cancer Research Centre, CNIO, Epithelial Cell Biology Group, Madrid, Spain

Department of Ophthalmology, University of Wisconsin, Wisconsin, USA

Neuropathology Unit, Institute of Experimental Neurology and Division of Neuroscience, IRCCS San Raffaele Scientific Institute (Section of Lecce), Milan, Italy.

Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, Lecce, Italy.

Interdisciplinary Department of Medicine, Section of Rheumatology, University of Bari Medical School, Bari 70124, Italy.

Department of Emergency and Organ Transplantation, Section of Pathological Anatomy, University of Bari Medical School, Bari, Italy

National Cancer Institute, Giovanni Paolo II Bari, Italy

Department of Internal Medicine and Clinical Oncology University of Bari Medical School Bari Italy

Ekuberg Pharma, Lecce, Italy

Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari, I-70124 Bari, Italy

Gastroenterological Hospital 'S. De Bellis' IRCCS, Laboratory of Immunopathology, Castellana Grotte, BA, Italy

Istituto Zooprofilattico Sperimentale della Puglia e Basilicata, Foggia, Italy

2008-to present Member of the Editorial Board of The Open Journal of Autoimmunity

Peer-Reviewed Publications

  1. Sisto M, Lorusso L, Ingravallo G, Tamma R, Nico B, Ribatti D, Ruggieri S, Lisi S. Reduced myofilament component in primary Sjögren's syndrome salivary gland myoepithelial cells. J Mol Histol. 2018 Jan 4. doi: 10.1007/s10735-017-9751-2.
  2. Sisto M, Lorusso L, Ingravallo G, Nico B, Ribatti D, Ruggieri S, Lofrumento DD, Lisi S. Abnormal distribution of AQP4 in minor salivary glands of primary Sjögren's syndrome patients. Autoimmunity. 2017 Jun;50(4):202-210. doi: 10.1080/08916934.2017.1341495.
  3. Sisto M, Lorusso L, Ingravallo G, Lisi S. Exocrine Gland Morphogenesis: Insights into the Role of Amphiregulin from Development to Disease. Arch Immunol Ther Exp (Warsz). 2017 Dec;65(6):477-499. doi: 10.1007/s00005-017-0478-2. Epub 2017 Jun 7. Review.
  4. Sisto M, Lorusso L, Lisi S. Interleukin-15 as a potential new target in Sjögren's syndrome-associated inflammation. Pathology. 2016 Oct;48(6):602-7. doi: 10.1016/j.pathol.2016.06.001.
  5. Sisto M, Lorusso L, Lisi S. TLR2 signals via NF-κB to drive IL-15 production in salivary gland epithelial cells derived from patients with primary Sjögren's syndrome. Clin Exp Med. 2016 Jun 3. [Epub ahead of print]
  6. Sisto M, Barca A, Lofrumento DD, Lisi S. Downstream activation of NF-κB in the EDA-A1/EDAR signalling in Sjögren's syndrome and its regulation by the ubiquitin-editing enzyme A20. Clin Exp Immunol. 2016 May;184(2):183-96. doi: 10.1111/cei.12764. Epub 2016 Feb 23.
  7. Sisto M, Lorusso L, Lisi S. X-linked ectodermal dysplasia receptor (XEDAR) gene silencing prevents caspase-3-mediated apoptosis in Sjögren's syndrome. Clin Exp Med. 2017 Feb;17(1):111-119. doi: 10.1007/s10238-015-0404-z. Epub 2015 Dec 11.
  8. Sisto M, Lisi S. New insights into ADAMs regulation of the GRO-α/CXCR2 system: focus on Sjögren's syndrome. Int Rev Immunol. 2015;34(6):486-99. doi: 10.3109/08830185.2014.975892. Epub 2014 Nov 11. Review.
  9. Lisi S, Sisto M, D'Amore M, Lofrumento DD. Co-culture system of human salivary gland epithelial cells and immune cells from primary Sjögren's syndrome patients: an in vitro approach to study the effects of Rituximab on the activation of the Raf-1/ERK1/2 pathway. Int Immunol. 2015 Apr;27(4):183-94. doi: 10.1093/intimm/dxu100. Epub 2014 Nov 8.
  10. Sisto M, Lisi S, D'Amore M, Lofrumento DD. The metalloproteinase ADAM17 and the epidermal growth factor receptor (EGFR) signaling drive the inflammatory epithelial response in Sjögren's syndrome. Clin Exp Med. 2015 May;15(2):215-25. doi: 10.1007/s10238-014-0279-4. Epub 2014 Mar 25.
  11. Lisi S, D'Amore M, Sisto M. ADAM17 at the interface between inflammation and autoimmunity. Immunol Lett. 2014 Nov;162(1 Pt A):159-69. doi: 10.1016/j.imlet.2014.08.008. Epub 2014 Aug 27. Review.
  12. Sisto M, Lisi S, Ingravallo G, Lofrumento DD, D'Amore M, Ribatti D. Neovascularization is prominent in the chronic inflammatory lesions of Sjögren's syndrome. Int J Exp Pathol. 2014 Apr;95(2):131-7.
  13. Sisto M, Lisi S, D'Amore M, Lofrumento DD. Rituximab-mediated Raf kinase inhibitor protein induction modulates NF-κB in Sjögren syndrome. Immunology. 2014 Sep;143(1):42-51.
  14. Lisi S, Sisto M, Ribatti D, D'Amore M, De Lucro R, Frassanito MA, Lorusso L, Vacca A, Lofrumento DD. Chronic inflammation enhances NGF-β/TrkA system expression via EGFR/MEK/ERK pathway activation in Sjögren's syndrome. J Mol Med (Berl). 2014 May;92(5):523-37. doi: 10.1007/s00109-014-1130-9. Epub 2014 Feb 21.
  15. Sisto M, Lisi S, Ingravallo G, Lofrumento DD, D'Amore M, Ribatti D (2013). Neovascularization is prominent in the chronic inflammatory lesions of Sjögren's Syndrome . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, ISSN: 0959-9673, in press. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  16. Sisto M, Lisi S, Lofrumento DD, Ingravallo G, De Lucro R, D'Amore M (2013). Salivary gland expression level of IκBα regulatory protein in Sjögren's syndrome. JOURNAL OF MOLECULAR HISTOLOGY, vol. 44, p. 447-454, ISSN: 1567-2379. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  17. D'Amore M, Lisi S, Sisto M, De Marino AV (2013). Paget's disease of bone: new therapeutic strategies. RECENTI PROGRESSI IN MEDICINA, vol. 104, p. 89-92, ISSN: 0034-1193.
  18. Lisi S, Sisto M, D'Amore M, Lofrumento DD, Ribatti D (2013). Emerging avenues linking inflammation, angiogenesis and Sjögren's syndrome. CYTOKINE, vol. 61, p. 693-703, ISSN: 1043-4666. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  19. Lisi S, Sisto M, Lofrumento DD, D'Amore M, De Lucro R, Ribatti D (2013). GRO-α/CXCR2 system and ADAM17 correlated expression in Sjögren's syndrome. INFLAMMATION, vol. 36, p. 759-766, ISSN: 0360-3997. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  20. Sisto M, Lisi S, D’Amore M, De Lucro R, Carati D, Castellana D,  La Pesa V, Zuccarello V, Lofrumento DD. (2012). Saponins from Tribulus Terrestris L. protect human keratinocytes from UVB-induced damage. Journal of Photochemistry & Photobiology, B: Biology, vol.117, p.193-201, ISSN: 1011-1344. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  21. Lisi S, Sisto M, Lofrumento DD, D'Amore M, De Lucro R, Ribatti D (2012). A potential role of the GRO-α/CXCR2 system in Sjögren's syndrome: regulatory effects of pro-inflammatory cytokines. HISTOCHEMISTRY AND CELL BIOLOGY, ISSN: 0948-6143, vol.139, p. 371-379. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  22. Lisi S, Sisto M, Lofrumento DD, D'Amore M (2012). Altered IkappaBalpha expression promotes NF-kappaB activation in monocytes from primary Sjögren's syndrome patients. PATHOLOGY, vol. 44(6), p. 557-561, ISSN: 0031-3025, doi: 10.1097/PAT.0b013e3283580388. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  23. Sisto M, Lisi S, Lofrumento DD, D'Amore M, Ribatti D (2012). Neuropilin-1 is upregulated in Sjögren's syndrome and contributes to pathological neovascularization. HISTOCHEMISTRY AND CELL BIOLOGY, vol. 137, p. 669-677, ISSN: 0948-6143, doi: 10.1007/s00418-012-0910-y. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  24. Notarnicola A, Lisi S, Sisto M, De Marino AV, D'Amore M. (2012). Possible role of oral ibandronate administration in Osteonecrosis of the Jaw: a case report. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, vol. 25, p. 312-316, ISSN: 0394-6320
  25. Lisi S, Sisto M, Lofrumento DD, D'Amore M (2012). Sjögren's syndrome autoantibodies provoke changes in gene expression profiles of inflammatory cytokines triggering a pathway involving TACE/NF-κB. LABORATORY INVESTIGATION, vol. 92, p. 615-624, ISSN: 0023-6837, doi: 10.1038/labinvest.2011.190. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  26. Sisto M, Lisi S, Lofrumento DD, D'Amore M, Frassanito MA, Ribatti D. (2012). Sjögren's syndrome pathological neovascularization is regulated by VEGF-A-stimulated TACE-dependent crosstalk between VEGFR2 and NF-κB.GENES AND IMMUNITY, vol. 13(5), p. 411-420, ISSN: 1466-4879, doi: 10.1038/gene.2012.9. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  27. SISTO M, LISI S, LOFRUMENTO DD, INGRAVALLO G, MAIORANO E, D'AMORE M (2011). A failure of TNFAIP3 negative regulation maintains sustained NF-κB activation in Sjögren's syndrome. HISTOCHEMISTRY AND CELL BIOLOGY, vol. 135, p. 615-625, ISSN: 0948-6143, doi: 10.1007/s00418-011-0821-3. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  28. Panaro MA, Calvello R, Mitolo CI, Sisto M, Cianciulli A. (2011). Evidence for endogenous retroviruses in human chemokine receptor gene introns: possible evolutionary inferences and biological roles. Immunopharmacol Immunotoxicol. vol. 33, p. 291-301.
  29. Panaro MA, Calvello R, Mitolo CI, Sisto M, Saccia M, Cianciulli A. (2011). An analysis of the human and mouse CXCR5 gene introns. Immunopharmacol Immunotoxicol. vol. 33, p 342-346.
  30. LISI S, SISTO M, LOFRUMENTO DD, D'AMORE S, D'AMORE M (2011). Advances in the understanding of the Fc gamma receptors-mediated autoantibodies uptake. CLINICAL AND EXPERIMENTAL MEDICINE, vol. 11, p. 1-10, ISSN: 1591-8890. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  31. LISI S, SISTO M (2010). Effects of biological drug adalimumab on tumour necrosis factor-alpha-converting enzyme activation. IMMUNOLOGY AND CELL BIOLOGY, vol. 88(3), p. 297-304, ISSN: 0818-9641. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  32. SISTO M, LISI S, LOFRUMENTO DD, INGRAVALLO G, MITOLO V, D'AMORE M (2010). Expression of pro-inflammatory TACE-TNF-alpha-amphiregulin axis in Sjögren's syndrome salivary glands. HISTOCHEMISTRY AND CELL BIOLOGY, vol. 34, p. 345-353, ISSN: 0948-6143, doi: 10.1007/s00418-010-0735-5. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  33. D'AMORE M, LISI S, SISTO M, CUCCI L, DOW CT (2010). Molecular identification of Mycobacterium avium subspecies paratuberculosis in an Italian patient with Hashimoto's thyroiditis and Melkersson-Rosenthal syndrome. JOURNAL OF MEDICAL MICROBIOLOGY, vol. 59(Pt1), p. 137-139, ISSN: 0022-2615.
  34. LISI S, SISTO M, LO FRUMENTO DD, CUCCI L, FRASSANITO MA, MITOLO V, DAMORE M (2010). Pro-inflammatory role of Anti-Ro/SSA autoantibodies through the activation of Furin-TACE-amphiregulin axis. JOURNAL OF AUTOIMMUNITY, vol. 35(2), p. 160-170, ISSN: 0896-8411. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  35. SISTO M, CUCCI L, D'AMORE M, DOW TC, MITOLO V, LISI S (2010). Proposing a relationship between Mycobacterium avium subspecies paratuberculosis infection and Hashimoto's thyroiditis. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, ISSN: 0036-5548
  36. LISI S, SISTO M, LOFRUMENTO D, FRASSANITO MA, CAPRIO S, ROMANO ML, MITOLO V, D'AMORE M (2010). Regulation of mRNA caspase-8 levels by anti-nuclear autoantibodies. CLINICAL AND EXPERIMENTAL MEDICINE, vol. 10(3), p. 199-203, ISSN: 1591-8890. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  37. SISTO M, LISI S, LOFRUMENTO DD, CAPRIO S, MITOLO V, D'AMORE M (2010). TNF blocker drugs modulate human TNF-alpha-converting enzyme pro-domain shedding induced by autoantibodies. IMMUNOBIOLOGY, vol. 215(11), p. 874-883, ISSN: 0171-2985. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  38. De Marino AV, Lisi S, Sisto M, D'Amore M. (2010). The treatment of the glucocorticoids-induced osteoporosis: recent knowledge]. RECENTI PROGRESSI IN MEDICINA, vol. 101, p. 330-332, ISSN: 0034-1193.
  39. PANARO MA, CIANCIULLI A, CALVELLO R, SACCIA M, SISTO M, ACQUAFREDDA A, MITOLO V (2009). An Analysis of the Human Chemokine CXC Receptor 4 Gene. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 31(1), p. 88-93, ISSN: 0892-3973
  40. LISI S, D'AMORE M, SCAGLIUSI P, MITOLO V, SISTO M (2009). Anti-Ro/SSA autoantibody-mediated regulation of extracellular matrix fibulins in human epithelial cells of the salivary gland. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, vol. 38 (3), p. 198-206, ISSN: 0300-9742.
  41. SISTO M, D'AMORE M, LOFRUMENTO DD, SCAGLIUSI P, D'AMORE S, MITOLO V, LISI S (2009). Fibulin-6 expression and anoikis in human salivary gland epithelial cells: implication in Sjogren's syndrome. INTERNATIONAL IMMUNOLOGY, vol. 21, p. 303-311, ISSN: 0953-8178
  42. SISTO M, LISI S, LOFRUMENTO DD, FRASSANITO MA, CUCCI L, D'AMORE S, MITOLO V, D'AMORE M (2009). Induction of TNF-alpha-converting enzyme-ectodomain shedding by pathogenic autoantibodies. INTERNATIONAL IMMUNOLOGY, vol. 21(12), p. 1341-1349, ISSN: 0953-8178. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  43. PANARO MA, SISTO M, MITOLO CI, CIANCIULLI A, MITOLO V (2009). Mutation, selection and the amino acid hydropathic character: a study on receptor genes involved in immune and non-immune functions. ENDOCRINE, METABOLIC & IMMUNE DISORDERS DRUG TARGETS, vol. 9 (1), p. 47-66, ISSN: 1871-5303
  44. D'AMORE M, DE MARINO AV, LISI S, SISTO M, SCAGLIUSI P, D'AMORE S (2009). New and old strategies against osteoporosis. RECENTI PROGRESSI IN MEDICINA, vol. 100(9), p. 393-400, ISSN: 0034-1193
  45. SISTO M, D'AMORE M, CAPRIO S, MITOLO V, SCAGLIUSI P, LISI S (2009). Tumor necrosis factor inhibitors block apoptosis of human epithelial cells of the salivary glands. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1171, p. 407-414, ISSN: 0077-8923
  46. SCAGLIUSI P, SISTO M, LISI S, LAZZARI A, D'AMORE M (2008). Hashimoto's thyroiditis in Melkersson-Rosenthal syndrome patient: casual association or related diseases?. PANMINERVA MEDICA, vol. 50(3), p. 255-257, ISSN: 0031-0808
  47. LISI S, D'AMORE M, LOFRUMENTO D, MITOLO V, FRASSANITO MA, DAMMACCO F, SCAGLIUSI P, SISTO M (2008). Modulation of the Fcγ receptors induced by anti-Ro and anti-La autoantibodies: observations in salivary gland cells. RHEUMATOLOGY INTERNATIONAL, vol. 28(9), p. 943-948, ISSN: 0172-8172
  48. SISTO M, D'AMORE M, SCAGLIUSI P, MITOLO V, LISI S (2008). Selective TNF-alpha gene silencing attenuates apoptosis in human salivary gland epithelial cells. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, vol. 21, p. 1045-1047, ISSN: 0394-6320
  49. SISTO M, LISI S, DAMORE M, MITOLO V, SCAGLIUSI P (2007). Anti-Ro and anti-La autoantibodies induce TNF- production by human salivary gland cells: an in vitro study. REUMATISMO, vol. 59, p. 221-226, ISSN: 0048-7449. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  50. SISTO M, LISI S, LOFRUMENTO D, DAMORE M, SCAGLIUSI P, MITOLO V (2007). Autoantibodies from Sjögren’s sindrome trigger apoptosis in salivary gland cell line. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1108, p. 418-425, ISSN: 0077-8923. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  51. LISI S, SISTO M, SOLETI R, SAPONARO C, SCAGLIUSI P, DAMORE M, SACCIA M, MAFFIONE A.B, MITOLO V (2007). Fcgamma receptors mediate internalization of anti-Ro and anti-La autoantibodies from Sjögren's syndrome and apoptosis in human salivary gland cell line A-253. JOURNAL OF ORAL PATHOLOGY & MEDICINE, vol. 36(9), p. 511-523, ISSN: 0904-2512. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  52. PANARO MA, ACQUAFREDDA A, SISTO M, LISI S, CALVELLO R, MITOLO CI, CIANCIULLI A, MITOLO V (2007). Formyl Peptide Receptors on Immune and Nonimmune Cells: Analysis of Sequence Conservation in FPR Genes. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 29(2), p. 243-269, ISSN: 0892-3973
  53. PANARO MA, CIANCIULLI A, LISI S, SISTO M, ACQUAFREDDA A, MITOLO V (2007). Formyl peptide receptor expression in birds. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 29 (1), p. 1-16, ISSN: 0892-3973
  54. PANARO MA, CIANCIULLI A, ACQUAFREDDA A, LISI S, MITOLO CI, SISTO M, CAVALLO P, MITOLO V (2007). Modeling of Granulocyte Cytoskeletal Responses Following fMLP Challenging. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 29(2), p. 201-224, ISSN: 0892-3973
  55. LISI S, SISTO M, SCAGLIUSI P, MITOLO V, D'AMORE M (2007). Siögren’s syndrome: anti-Ro and anti-La autoantibodies trigger apoptotic mechanism in the human salivary gland cell line, A-253. PANMINERVA MEDICA, vol. 49, p. 103-108, ISSN: 0031-0808. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  56. SISTO M, LISI S, CASTELLANA D, SCAGLIUSI P, D'AMORE M, CAPRIO S, SCAGLIUSI A, ACQUAFREDDA A, PANARO MA, MITOLO V (2006). Autoantibodies from Sjogren's syndrome induce activation of both the intrinsic and extrinsic apoptotic pathways in human salivary gland cell line A-253. JOURNAL OF AUTOIMMUNITY, vol. 27(1), p. 38-49, ISSN: 0896-8411. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  57. PANARO MA, ACQUAFREDDA A, SISTO M, LISI S, MAFFIONE AB, MITOLO V (2006). Biological role of the N-formyl peptide receptors. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 28(1), p. 103-127, ISSN: 0892-3973
  58. SISTO M, PANARO MA, ACQUAFREDDA A, LISI S, MAFFIONE AB, MITOLO V (2006). Chemokine CXC receptor 4: an evolutionary approach. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 28 (4), p. 715-738, ISSN: 0892-3973
  59. PANARO MA, ACQUAFREDDA A, SISTO M, LISI S, SACCIA M, MITOLO V (2006). Evolution of a “conserved” amino acid sequence: a model study of an in silico investigation of the phylogenesis of some immune receptors. CURRENT PHARMACEUTICAL DESIGN, vol. 12 (32), p. 4091-4121, ISSN: 1381-6128
  60. SISTO M, ACQUAFREDDA A, MITOLO V, PANARO MA, LISI S, SACCIA M (2006). Polimorphonuclear cell-mediated oxidative stress: sink for reactive oxygen species and cell various type damage. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 28(1), p. 153-164, ISSN: 0892-3973
  61. LISI S, CALVELLO R, PANARO MA, MAFFIONE AB, SISTO M, MITOLO V (2006). The 18S rRNA is basically composed of two tandem quasirepeats. Insights into the evolution of some innate immunity receptors. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 28 (4), p. 651-663, ISSN: 0892-3973
  62. LISI S, SISTO M, ACQUAFREDDA A, SPINELLI R, SCHIAVONE M, MITOLO V, BRANDONISIO O, PANARO M. (2005). Infection with Leishmania infantum Inhibits actinomycin D-induced apoptosis of human monocytic cell line U-937. JOURNAL OF EUKARYOTIC MICROBIOLOGY, vol. 52, p. 211-217, ISSN: 1066-5234. Sisto M. and Lisi S. contributed equally and should be considered as first authors
  63. PANARO MA, ACQUAFREDDA A, SISTO M, LISI S, CALVELLO R, SACCIA M, MAFFIONE AB, MITOLO V. (2005). Structural similarities between mRNA for the formyl peptide receptors and 18S rRNA. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol. 27, p. 267-284, ISSN: 0892-3973, doi: 10.1081/IPH-200067768
  64. PANARO MA, SPINELLI R, LISI S, SISTO M, ACQUAFREDDA A, FUMAROLA L, MITOLO V, BRANDONISIO O. (2004). Reduced expression of the chemokine receptor CCR1 in human macrophages and U-937 cells in vitro infected with Leishmania infantum. CLINICAL AND EXPERIMENTAL MEDICINE, vol. 3, p. 225-230, ISSN: 1591-8890, doi: 10.1007/s10238-004-0029-0
  65. PANARO MA, BRANDONISIO O, ACQUAFREDDA A, SISTO M, MITOLO V. (2003). Evidences for iNOS expression and nitric oxide production in the human macrophages. CURRENT DRUG TARGETS- IMMUNE, ENDOCRINE & METABOLIC DISORDERS, vol. 3, p. 210-221, ISSN: 1568-0088, doi: 10.2174/1568008033340216
  66. BRANDONISIO O, PANARO MA, FUMAROLA I, SISTO M, LEOGRANDE D, ACQUAFREDDA A, SPINELLI R, MITOLO V. (2002). Macrophage chemotactic protein-1 and macrophage inflammatory protein-1 alpha induce nitric oxide release and enhance parasite killing in Leishmania infantum-infected human macrophages. CLINICAL AND EXPERIMENTAL MEDICINE, vol. 2, p. 125-129, ISSN: 1591-8890, doi: 10.1007/s102380200017
  67. PANARO MA, AMATI L, SISTO M, CARADONNA L, LISI S, MITOLO V, FUMAROLA D. (2001). Embryonal cardiotoxicity of the Helicobacter pylori lipopolysaccharide. CURRENT DRUG TARGETS-IMMUNE, ENDOCRINE & METABOLIC DISORDERS, vol. 1, p. 31-44, ISSN: 1568-0088, doi: 10.2174/1568008013341613
  68. SISTO M, BRANDONISIO O, PANARO MA, ACQUAFREDDA A, LEOGRANDE D, FASANELLA A, TROTTA T, FUMAROLA L, MITOLO V (2001). Inducible nitric oxide synthase expression in Leishmania-infected dog macrophages. COMPARATIVE IMMUNOLOGY, MICROBIOLOGY AND INFECTIOUS DISEASES, vol. 24, p. 247-254, ISSN: 0147-9571, doi: 10.1016/S0147-9571(01)00013-3
  69. BRANDONISIO O, PANARO MA, SISTO M, ACQUAFREDDA A, FUMAROLA L, LEOGRANDE D, MITOLO V. (2001). Nitric oxide production by Leishmania-infected macrophages and modulation by cytokines and prostaglandins. PARASSITOLOGIA, vol. 43, suppl.1, p. 1-6, ISSN: 0048-2951
  70. PANARO MA, BRANDONISIO O, SISTO M, ACQUAFREDDA A, LEOGRANDE D, FUMAROLA L, MITOLO V. (2001). Nitric oxide production by Leishmania-infected macrophages and modulation by prostaglandin E2. CLINICAL AND EXPERIMENTAL MEDICINE, vol. 1, p. 137-143, ISSN: 1591-8890, doi: 10.1007/s10238-001-8025-0
  71. PANARO MA, ACQUAFREDDA A, LISI S, LOFRUMENTO DD, MITOLO V, SISTO M, FASANELLA A, TROTTA T, BERTANI F, CONSENTI B, BRANDONISIO O. (2001). Nitric oxide production by macrophages of dogs vaccinated with killed Leishmania infantum promastigotes. COMPARATIVE IMMUNOLOGY, MICROBIOLOGY AND INFECTIOUS DISEASES, vol. 24, p. 187-195, ISSN: 0147-9571, doi: 10.1016/S0147-9571(00)00026-6
  72. BRANDONISIO O, PANARO MA, SISTO M, ACQUAFREDDA A, FUMAROLA L, LEOGRANDE D. (2000). Interactions between Leishmania parasites and host cells. PARASSITOLOGIA, vol. 42, p. 183-190, ISSN: 0048-2951

 

ABSTRACTS PUBLISHED IN PEER REVIEWED JOURNALS

  1. D'Amore M, Lisi S, De Lucro R, Ribatti D, Sisto M (2013). IKBA REGULATORY PROTEIN IS DOWNREGULATED IN SJÖGREN'S SYNDROME SALIVARY GLAND EPITHELIAL CELLS . ANNALS OF THE RHEUMATIC DISEASES, vol. 72, ISSN: 0003-4967
  2. D'Amore M, Sisto M, De Lucro R, Ribatti D, Lisi S (2013). ADAM17 INFLUENCES THE GRO-A/CXCR2 SYSTEM EXPRESSION IN SJÖGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES, vol. 72, ISSN: 0003-4967
  3. D'Amore M, Sisto M, Scagliusi P, Cucci L, Lisi S (2011). TUMOR NECROSIS FACTOR-ΑLPHA TRIGGERS THE FURIN-TACE-AMPHIREGULIN AXIS IN SJÖGREN’S SYNDROME. ANNALS OF THE RHEUMATIC DISEASES, vol. 70, p. 688, ISSN: 0003-4967
  4. D'Amore M, Lisi S, Scagliusi P, Cucci L, Sisto M (2011). ANTI-TUMOR NECROSIS FACTOR-ΑLPHA DRUGS MODULATE HUMAN ADAM-17 EXPRESSION IN SJÖGREN’S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES, vol. 70, p. 738, ISSN: 0003-4967
  5. LISI S, D'AMORE M, SCAGLIUSI P, CUCCI L, SISTO M (2010). Effects of Biological drugs Adalimumab and Etanercept on TNF-Alpha-Converting Enzyme activation. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol. 40 (1), p. 62, ISSN: 0014-2972
  6. M. D'AMORE, S. LISI, P. SCAGLIUSI, L. CUCCI, SISTO M (2010). Effects of biological drugs on TNF-alpha-converting enzyme activation. ANNALS OF THE RHEUMATIC DISEASES, vol. 69(3), ISSN: 0003-4967
  7. D'AMORE M, SISTO M, LISI S, D'AMORE S, MITOLO V, SCAGLIUSI P (2009). Adalimumab influences TNF-Alpha converting enzyme expression. REUMATISMO, vol. 61 (1), p. 190, ISSN: 0048-7449
  8. SISTO M, D'AMORE M, SCAGLIUSI P, MITOLO CI, MAFFIONE AB, LISI S (2009). Anti tumor-necrosis-factor agents block apoptosis of non-neoplastic human salivary gland epithelial cells. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 114/suppl.1, ISSN: 1122-6714
  9. D'AMORE M, SISTO M, LISI S, D'AMORE S, MITOLO V, SCAGLIUSI P (2009). Anti tumor-necrosis-factor agents block apoptosis of non-neoplastic human salivary gland epithelial cells: a comparative study. REUMATISMO, vol. 61 (1), p. 189, ISSN: 0048-7449
  10. LISI S, D'AMORE M, MITOLO CI, SCAGLIUSI P, TROTTA T, CARINGELLA ME, CUCCI L, SISTO M (2009). Pathogenic autoantibodies modulate extracellular matrix protein expression. EUROPEAN JOURNAL OF HISTOCHEMISTRY, vol. 53/suppl. 1, ISSN: 1121-760X
  11. PANARO M.A, SAPONARO C, SACCIA M, LISI S, SISTO M, LEPORE S, TROTTA T, MITOLO V (2008). Brain inflammation induced by lipopolysaccharide: the role of CD14/TLR4 complex. An in vitro study. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 113(1), ISSN: 1122-6714
  12. CIANCIULLI A, ACQUAFREDDA A, SISTO M, CAVALLO P, CARINGELLA M.E, LEPORE S, PORRO C, PANARO M.A (2008). NF-kB protective role in the f-met-leu-phe challenger chick embryo neurons. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 113(1), ISSN: 1122-6714
  13. SISTO M, DAMORE M, SCAGLIUSI P, CALVELLO R, CARINGELLA ME, LISI S (2008). Transcriptional regulation of human caspase-8 gene in non-neoplastic human salivary gland epithelial cells: implications in Sjögren’s syndrome. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 113 (suppl. 1 a fascicolo 2), p. 262, ISSN: 1122-6714
  14. LEPORE S, PANARO M.A, SISTO M, LISI S, ACQUAFREDDA A, MITOLO C.I, CIANCIULLI A, PORRO C, SCAGLIUSI P, DAMORE M (2007). Fc gamma receptors are involved in the anti-Ro and anti-La autoantibodies penetration into salivary gland cells: an in vitro study. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 112 (1), ISSN: 1122-6714
  15. SISTO M, LISI S, MITOLO V, D'AMORE M, SCAGLIUSI P (2007). ROLE OF ANTI-RO AND ANTI-LA AUTOANTIBODIES FROM SJÖGREN'S SYNDROME: MECHANISM OF TNF-ALPHA-MEDIATED CELL DEATH IN HUMAN SALIVARY GLAND CELL LINE. REUMATISMO, vol. 59, ISSN: 0048-7449
  16. LISI S, SISTO M, MITOLO V, SCAGLIUSI P, D'AMORE M (2007). SJÖGREN'S SYNDROME: APOPTOSIS TRIGGERED BY BINDING OF ANTI-RO AND ANTI-LA AUTOANTIBODIES TO THE FC GAMMA RECEPTORS. REUMATISMO, vol. 59, ISSN: 0048-7449
  17. PANARO M.A, SISTO M, LISI S, LEPORE S, MITOLO C.I, SACCIA M, TROTTA T, MITOLO V, SCAGLIUSI P, DAMORE M (2007).Tumor necrosis factor-alpha related apoptosis in human salivary gland cells treated with anti-Ro and anti-La autoantibodies from Sjögren’s syndrome. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 112 (1), ISSN: 1122-6714
  18. LISI S, DAMORE M, SISTO M, CAPRIO S, SACCIA M, CALVELLO R (2006). Caspase-3 is activated in a salivary gland cell line by Sjögren syndrome autoantibodies. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 111 (3, suppl. 2), ISSN: 1122-6714
  19. SISTO M, SCAGLIUSI P, LISI S, PORRO C, CAPRIO S (2006). Sjögren’s syndrome autoantibodies induce activation of both intrinsic and extrinsic apoptotic pathways in the human salivary gland cell line A-253. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 111 (3, suppl. 2), ISSN: 1122-6714
  20. SPINELLI R, SISTO M, ACQUAFREDDA A. (2005). Induction of nitric oxide release and enhancement of parasite killing by CCL2 and CCL3 chemokines and reduced expression of the CCR1 in human macrophages in vitro infected with Leishmania infantum. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 110, ISSN: 1122-6714
  21. SCAGLIUSI P, LISI S, SISTO M, PANARO MA, CAPRIO S, D'AMORE M, MINENNA G, D'AMORE S, SCAGLIUSI A (2005). La Patogenesi della Sindrome Secca autoanticorpi anti-SSA e anti-SSB e apoptosi. REUMATISMO, vol. 57 (4), ISSN: 0048-7449
  22. SISTO M, CALVELLO R, MAFFIONE AB. (2005). Role of CD14 in lipopolysaccharide-induced toxicity on chick embryo cardiomyocytes. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 110, ISSN: 1122-6714
  23. SISTO M, MAFFIONE AB, MITOLO CI, MITOLO V, SACCIA M. (2004). Cell differential absorbance of ROS products and differential cell damage. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 109, ISSN: 1122-6714
  24. SISTO M, ACQUAFREDDA A., GAGLIARDI N., PRICCI M. (2004). Inhibition of apoptosis in the monocytic cell line U-937 following in vitro infection with leishmania infantum. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 109, p. 322, ISSN: 1122-6714
  25. MITOLO V, CALVELLO R, CAVALLO P, SACCIA M, SISTO M (2003). Intracellular infection by Leishmania infantum inhibits human macrophage apoptosis. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 108, ISSN: 1122-6714
  26. PANARO MA, SISTO M, MITOLO CI, LISI S, MEZZINA L. (2003). Regulation of CCR1 expression in human macrophages in vitro infected with Leishmania infantum. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 108, ISSN: 1122-6714
  27. BRANDONISIO O, PANARO MA, FUMAROLA L, ACQUAFREDDA A, SPINELLI R, SISTO M, MITOLO V. (2002). Enhanced nitric oxide release and parasite killing in Leishmania infantum-infected human macrophages treated with macrophage chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1. PARASSITOLOGIA, vol. 44, ISSN: 0048-2951
  28. MITOLO CI, AMATI L, CARADONNA L, SISTO M, LISI S, MITOLO V, PANARO MA. (2001). Cardiotoxicity of the Helicobacter pylori lipopolysaccharide to the embryo. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, vol. 291, suppl.31, ISSN: 1438-4221
  29. BRANDONISIO O, PANARO MA, SISTO M, ACQUAFREDDA A, LEOGRANDE D, FUMAROLA L. (2001). Expression of inducible nitric oxide synthase (iNOS) in dog macrophages in vitro infected with Leishmania infantum. JOURNAL OF EUKARYOTIC MICROBIOLOGY, vol. 48, ISSN: 1066-5234
  30. MEZZINA L, MITOLO V, SACCIA M, SISTO M (2001). Homologies between the 18S ribosomal RNA and the fMLP-receptor mRNA. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 106, ISSN: 1122-6714
  31. PANARO MA, SISTO M, ACQUAFREDDA A, CAVALLO P. (2001). In vitro comparison between three vaccines against Leishmaniosis, with reference to the dog macrophage killing activity. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 106, ISSN: 1122-6714
  32. PANARO MA, ACQUAFREDDA A, LISI S, SISTO M, TROTTA T, SATALINO R, MITOLO V, BRANDONISIO O. (2000). Detection of Inducible Nitric Oxide Synthase and Nitric Oxide Production in Leishmania infantum-infected Human Macrophages. JOURNAL OF EUKARYOTIC MICROBIOLOGY, vol. 47, ISSN: 1066-523
  33. MAFFIONE AB, TROJANO M, CALVELLO R, SISTO M, MITOLO CI, JIRILLO E. (2000). Effects of intravenous gamma-globulin administration on the immune response in patients with multiple sclerosis. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 105, ISSN: 1122-6714
  34. BRANDONISIO O, PANARO MA, SISTO M, ACQUAFREDDA A, LEOGRANDE D, FASANELLA A. (2000). Inducible nitric oxide synthase expression in Leishmania-infected dog macrophages. ACTA PARASITOLOGICA, vol. 45, ISSN: 1230-2821
  35. SISTO M, SACCIA M, LISI S. (2000). Role of prostaglandin E2 (PGE2) on nitric oxide production by human macrophages. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 105, ISSN: 1122-6714