International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.


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Members

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XIN WANG

Founder, CEO and Chief Science Officer

During ten years of clinical practice and clinical research, I was awarded the FIRST PRIZE of EXCELLENT PAPER in national Neurologic Rehabilitation Annual Meeting 1998 in China.
In Japan for my PhD degree in Medical Science. I discovered the full length cDNA sequence of BAALC1-6-8 in mammal (Dem A20-4, GenBankTM NO. AB073318), which later was identified as a biomarker for acute leukemia associated with stem cell differentiation, I am the first one who studied BAALC1-6-8  at molecular and cellular biology level and discovered the protein of this gene targeting to membrane(Lipid Raft) through post-translational modifications of its N-terminal motif.
During my postdoc training in National Cancer Institute of NIH in USA, I identified a genetic mutated CERT(an important gene in lipid metabolism of mammal) mouse model that die from cardiovascular dysfunction in embryonic development. This publication had been pointed as "must read" by Faculty 1000.
As a primary author, my research project summary about tumor microenvironment gained "Minority Scholar Award" in AACR meeting.

Based on my knowledge and experience in medical research, a hypothesis of therapeutic strategy of vascular disease and cancer has been established. I found my biotech company in 2013 collaborating with my chinese colleagues in hospitals studying animal models of CODP and MS, and continuing clinical trials. My career goal is to improve human health through scientific critical studies on basic, translational, preventive and clinical research.

 

 

1, Angiogenesis animal Model in Periodontists Rats

2, Hypertension in Chronic Occlusive Pulmonary Disease (COPD)

3, Neovascularizition Affect of Dexamethasone in Multiple Scleroses (MS) mouse models

4, Natural Products on Treatment of Infectious Diseases of Spinal cord (Clinical Trails)

5, Immunotherapy of Cancer

6, Mitochondrial dysfunction in degeneration diseases

7, Leukemia Surveillance

8, Radiation and Human Metabolism 

Minority Scholar Award in AACR—tumor microenvironment complexity: Emerging Roles in
Cancer Therapy in Orlando, FL. 2011 (First Author of Abstract: Role of Intratumoral Hypoxia
on Tenascin C expression in Oropharyngeal)

Faculty of 1000 appointed this paper as “MUST READ”: Wang X, ..., Acharya JK. Mitochondrial Degeneration and Not Apoptosis is the Primary cause of Embryonic Lethality in Ceramide Transfer Protein Mutant Mice. Journal of Cell Biology. 184: 143-158, 2009

Based on discovery of Dem A20-4, patent Leukemia Diagnosis Kit approved (Tatsuo Suzuki's laboratory, L0400008, September 16, 2004)

Discovery of a rat brain-specific cDNA of Dem A20-4 (GenBankTM NO. AB073318, March 16, 2001), which is later named BAALC1-6-8

Women Scholarship for Foreign Students in Japan, 2001

1st Prize of Excellent Paper in the 3rd National Neurologic Rehabilitation Annual Meeting in China, 1998

SOJ Microbiology and Infectious Diseases(2013-present):

http://symbiosisonlinepublishing.com/microbiology-infectiousdiseases

Journal of Microbiology and Experimentation(2014-present):

http://medcraveonline.com/JMEN

Journal of Cardiology and Current Research(2014-present):

http://medcraveonline.com/JCCR (Advisory Board Member)