International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.


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Members

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Changsheng Du

Professor/Principle Investigator

  • The B.S. in Biology from Hubei Normal University in 1999
  • The M.S. in Cell Biology from Central China Normal University in 2002
  • The Ph.D. in Virology from Institute of Hydrobiology, Chinese Academy of Sciences in 2005
  • The Postdoctoral studies in Cell Biology from Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences in 2009.

Multiple sclerosis (MS) is an autoimmune disease with repeated attacks and progressive disease severity, most people are diagnosed between the ages of 20-40. There is no effective therapeutic drug for MS at present which exhausted the patients and the family members. The main causes for these difficulties were the unknown disease mechanisms and the lack of effective drug targets of MS. Our research focus on studying disease pathogenesis of MS and exploring drug targets for disease treatment, finally to propose a multiple targets orientated therapeutic strategy for MS treatment in the future. During the past years, we revealed the important regulatory function of microRNA (miR-326) and G protein-coupled receptors (GPCR: Opioid receptors, cysLT1 and A2B) in MS pathogenesis. These findings were published as first author or corresponding author in the peer reviewed journals including Nat Immunol, Nat Commun, J Immunol, Cell Res, JBC, CMI which attracted great interests of colleagues from all over the world, and were given comments in Nat Immunol, Nature China, Faculty of 1000. And our findings were selected as “Editors’ choice” and “Editors’ Pick” by Science Signaling and MS Discovery Forum respectively.

  • Cuixia Yang, Weiming Lai, Jinfeng Zhou, Xinyuan Zheng, Yingying Cai, Wanjie Yang, Sirong Xie, Yuan Gao, Changsheng Du#. Betaine Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Dendritic Cell-Derived IL-6 Production and Th17 Differentiation. Journal of Immunology, 2018, 200(4): 1316-1324.
  • Chaoyan Qin*, Jinfeng Zhou*, Yuan Gao*, Weiming Lai, Cuixia Yang, Yingying Cai, Shuai Chen, Changsheng Du#. Critical Role of P2Y12 Receptor in Regulation of Th17 Differentiation and Experimental Autoimmune Encephalomyelitis Pathogenesis. Journal of Immunology. 2017, 199(1): 72-81.
  • Weiming Lai *, Yingying Cai *, Jinfeng Zhou, Shuai Chen, Chaoyan Qin, Cuixia Yang, Junling Liu, Xin Xie, Changsheng Du#. Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation. Cellular & Molecular Immunology. 2017, 14(6): 557-567.
  • Shuai Chen, Jinfeng Zhou, Yingying Cai, Chaoyan Qin, Weiming Lai, Cuixia Yang, Xin Xie, Changsheng Du#. Discovery of BVDU as a promising Drug for autoimmune diseases Therapy by Dendritic-cell-based functional screening. Scientific Reports. 2017, 7: 43820.
  • Yingying Cai, Hu Shen, Chaoyan Qin, Jinfeng Zhou, Weiming Lai, Juping Pan, Changsheng Du#. The Spatio-Temporal Expression Profiles of CD4 + T Cell Differentiation and Function-Related Genes During EAE Pathogenesis. Inflammation, 2017, 40(1): 195-204.
  • Changsheng Du *, Yanhui Duan *, Wei Wei, Yingying Cai, Hui Chai, Jie Lv, Xiling Du, Jian Zhu, Xin Xie. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination. Nature Communications. 2016, 7: 11120-11129.
  • Wei Wei*, Changsheng Du*(Co-first), Jie Lv, Guixian Zhao, Zhenxin Li, Zhiying Wu, Xin Xie. A2B Adenosine Receptor Antagonist alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and TH-17 Differentiation. Journal of Immunology. 2013, 190(1): 138-146.
  • Jie Lv*, Changsheng Du*(Co-first), Wei Wei, Zhiying Wu, Guixian Zhao, Zhenxin Li, Xin Xie. The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. JBC. 2012, 187(34): 28656-28665.
  • Changsheng Du, Xin Xie. G Protein-Coupled Receptors as Therapeutic Targets for Multiple Sclerosis. Cell Research. 2012, 22(7): 1108-1128.
  • Changsheng Du*, Chang Liu*, Jiuhong Kang, Guixian Zhao, Zhiqiang Ye, Shichao Huang, Zhenxin Li, Zhiying Wu, Gang Pei. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nature Immunology. 2009, 10(12): 1252-1259.