International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.


committee

Members

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Veerendra Koppolu

senior scientist

Veerendra KoppoluM.ScPh.DC.Cy is a senior scientist in the Department of Biologics Development at AstraZeneca/Medimmune in Gaithersburg, Maryland, USA. Dr. Koppolu is also a honorary faculty member at non-profit organization Novel Global Community Education Foundation (NGCEF) focused in guiding doctoral students. His lectures are highly valued and was awarded Robert H Emmer award and Michael S Gaines awards for this teaching. Dr. Koppolu has published over 50 peer-reviewed papers including research article, review articles, abstracts, book chapters, and books. Dr. Koppolu is serving as reviewer of 30 peer-reviewed international journals including Biotechnology Journal, Journal of Bacteriology, Future microbiology etc. Dr. Koppolu is Editorial advisory board member of International Journal of Applied and Natural Sciences, Editor of Oncology Reports and Reviews, Editor of Holistic Approaches in Oncotherapy, Editor of Open Access Journal of Surgery, Associate Editor of Cancer Therapy and Oncology International Journal, Associate Editor of Research Reviews on healthcare. Dr. Koppolu is a member in international scientific communities such as “American chemical society, American Society of Microbiology, American Association of cancer research, American Society of clinical oncology, and Internationally certified flow cytometry Association. His primary research interests include pre-clinical and clinical development of immunotherapeutic drugs including monoclonal antibodies, bispecifics, and antibody drug conjugates.  At AstraZeneca, he helped in the development of drug Durvalumab, an FDA approved drug that prevents tumor immune suppression in urinary bladder cancer. He also worked in the development of immunotherapeutic vaccines for triple negative breast cancer. Dr. Koppolu holds a BS and M.Sc (Biotech) from India, PhD from University of Kansas (USA), and a certification in Flow Cytometry (C.Cy)

Ph.D – Cell, Molecular and Developmental Biology

University of Kansas                                                                                   

  • Molecular Mechanisms and Inhibition of Transcription Activation by AraC Family Virulence Activators2008-2013, Lawrence, Ks

M.S – Biotechnology

CSKHPKV University

  • Molecular characterization and diagnosis of viral diseases
    2005-2007, Palampur, India

 

Pre-clinical and clinical development of monoclonal antibodies and novel small molecules as breakthrough therapies for cancer and infectious diseases. Characterization and Potency evaluation of drugs and vaccines.

 

  • Doctoral dissertation defense award (2013)
  • Outstanding Teaching Assistant Award – Microbiology (2012)
  • Outstanding Teaching Assistant Award - Principles of Biology (2009)
  • Nomination for Youth Exchange Program between India and China (2007)
  • Master’s thesis award (2007)
  • BiotechnologyJunior Research Fellowship (2005- 2007)

 

Veerendra Koppolu, Ichie Osaka, Jeff M. Skredenske, Bria Kettle, Scott Hefty and Susan M. Egan “Small molecule inhibitor of Shigella flexneri master virulence regulator, VirF”. Infect Immun. 2013 Nov;81(11):4220-31. PMID: 24002059

Jeff M. Skredenske, Veerendra Koppolu, Ana Kolin, James Deng, Bria Kettle, Byron Taylor and Susan M. Egan “Identification of a small molecule inhibitor of bacterial AraC family activators”. J Biomol Screen. 2013 Jun;18(5):588-98. (PMID: 23364515)

Veerendra Koppoluand Susan M. Egan “Small molecule inhibitor of Shigella flexneri master virulence regulator, VirF”. 7th Asia-Pacific Biotech Congress 2015, China. Abstract

Veerendra Koppolu and Veneela KR Vasigala. "Role of Escherichia coli in Biofuel Production." Microbiology Insights 9 (2016): 29.

Veerendra Koppolu, Veneela KR Vasigala (2016)CTLA-4 Antibodies in Cancer Immunotherapy. MOJ Immunol 3(3): 00092. DOI: 10.15406/moji.2016.03.00092

Veerendra Koppolu, Veneela KR Vasigala(2016) Nivolumab in the treatment of Metastatic Melanoma. (Accepted, Journal of Cancer Research and Therapeutics)

SriHari Raju Mulagapati, Veerendra Koppolu, Raju T Shantha (2017) Decoding of O-linked Glycosylation by Mass Spectrometry. Biochemistry, 201756 (9), pp 1218–1226

Veerendra Koppolu, Veneela KR Vasigala(2017)Cancer Immunotherapy Arsenal: Current and Promising New Approaches. Cancer Therapy and Oncology International Journal. Volume 5 Issue 3 - May 2017