International Journal of Immunology is a peer-reviewed open access journal that publishes original research articles as well as review articles in all areas of immunology. Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defense mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in biological sciences. This remarkable growth is stimulated by the influx of investigators from other disciplines such as biochemistry, genetics, molecular biology, microbiology, virology and various medical disciplines. These disciplines are so well interlinked with immunology that no immunological challenge can now be properly addressed without sophisticated applications of expertise of combinations of these disciplines. As a consequence, immunology has become a vast and rich field encompassing discoveries and outlooks that range from the highly clinical to the highly molecular. Although such perspectives may appear diverse, they are, in fact, extremely interdependent. The journal seeks to present a balanced overview of contemporary immunology and melds together different aspects of molecular immunology, immunobiology and clinical immunology.

Immunology is the branch of biomedical science that deals with the response of an organism to antigenic challenge and its recognition of what is self and what is not. It deals with the defense mechanisms including all physical, chemical and biological properties of the organism that help it to combat its susceptibility to foreign organisms, material, etc

Immunology has its origins in the study of how the body protects itself against infectious diseases caused by microorganisms, such as bacteria, viruses, protozoa, and fungi, and also parasitic organisms, such as helminth worms. Research / review articles deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo are of prime interest.




Maurizio Sorice

Full Professor

1989 Specialist in “Allergology and Immunology”, “Sapienza" University, Rome, Italy.
1986 Graduate, "Sapienza" University, Rome, Italy, School of Medicine.

1) Ceccarelli S, Nodale C, Vescarelli E, Pontecorvi P, Manganelli V, Casella G, Onesti MG, Sorice M, Romano F, Angeloni A, Marchese C.
Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis. Stem Cells
Int. 2018 Feb 25;2018:1075156.
2) Garofalo T, Ferri A, Sorice M, Azmoon P, Grasso M, Mattei V, Capozzi A, Manganelli V, Misasi R. (2018) Neuroglobin overexpression plays a
pivotal role in neuroprotection through mitochondrial raft-like microdomains in neuroblastoma SK-N-BE2 cells. Mol Cell Neurosci 88: 167-176.
3) Manganelli V, Capozzi A, Truglia S, Alessandri C, Lococo E, Garofalo T, De Carolis C, Conti F, Valesini G, Sorice M, Longo A, Misasi R.
(2017) Elevated serum level of HMGB1 in patients with the Antiphospholipid Syndrome. J Immunol Res 2017: 4570715.
4) Zohoury N, Bertolaccini ML, Rodriguez-Garcia JL, Shums Z, Ateka-Barrutia O, Sorice M, Norman GL, Khamashta M. (2017) Closing the
serological gap in the Anti-Phospholipid Syndrome: The value of “Non-criteria” Antiphospholipid Antibodies. J Rheumatol. 44: 1597-1602.
5) Conti F, Priori R, Alessandri C, Misasi R, Capozzi A, Pendolino M, Truglia S, Frisenseda S, Sorice M, Valesini G. (2017) Diagnosis of
catastrophic anti-phospholipid syndrome in a patient tested negative for conventional tests. Clin Exp Rheumatol 35: 678-680.
6) Degli Esposti M, Matarrese P, Tinari A, Longo A, Recalchi S, Khosravi-Far R, Malorni W, Misasi R, Garofalo T, Sorice M. (2017) Changes in
membrane lipids drive increased endocytosis following Fas ligation. Apoptosis 22: 681-695.
7) Alessandri C, Agmon-Levin N, Conti F, Perricone C, Ortona E, Pendolino M, Capozzi A, Delunardo F, Mancini R, Truglia S, Spinelli FR,
Ceccarelli F, Sorice M, Shoenfeld Y, Valesini G. (2017) Anti-mutated citrullinated vimentin antibodies in antiphospholipid syndrome: diagnostic
value and relationship with clinical features. Immunol Res 65: 524-531
8) Mattei V, Martellucci S, Santilli F, Manganelli V, Garofalo T, Candelise N, Caruso A, Sorice M, Scaccianoce S, Misasi R. (2017) Morphine
Withdrawal Modifies Prion Protein Expression in Rat Hippocampus. PLoS One 12: e0169571.
9) Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias SL, Mantuano E. (2016) The activities of LDL Receptor-related Protein-1 (LRP1)
compartmentalize into distinct plasma membrane microdomains. Mol Cell Neurosci 76: 42-51.
10) Garofalo T, Matarrese P, Manganelli V, Marconi M, Tinari A, Gambardella L, Faggioni A, Misasi R, Sorice M, Malorni W. (2016) Evidence for
the involvement of lipid rafts localized at the ER-mitochondria associated menbranes in autophagosome phormation. Autophagy 12: 917-935.
11) Sorice M, Iannuccelli C, Manganelli V, Capozzi A, Alessandri A, Lococo E, Garofalo T, Di Franco M, Bombardieri M, Nerviani A, Misasi R,
Valesini G. (2016) Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies.
Rheumatology 55: 1374-1385.
12) Klionski DJ…Sorice M et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 12: 1-222.
13) Sorice M, Buttari B, Capozzi A, Profumo E, Facchiano F, Truglia S, Recalchi S, Alessandri C, Conti F, Misasi R, Valesini G, Riganò R. (2016)
Antibodies to age-β2 glycoprotein I in patients with antiphospholipid antibody syndrome. Clin Exp Immunol 184: 174-182.
14) Mattei V, Santacroce C, Tasciotti V, Martellucci S, Santilli F, Manganelli V, Piccoli L, Misasi R, Sorice M, Garofalo T. (2015) Role of lipid rafts in
neuronal differentiation of dental pulp-derived stem cells. Exp Cell Res 339: 231-240.
15) Manganelli V, Capozzi A, Recalchi S, Signore M, Mattei V, Garofalo T, Misasi R, Degli Esposti M, Sorice M. (2015) Altered traffic of cardiolipin
during apoptosis: Exposure on the cell surface as a trigger for “antiphospholipid antibodies”. J Immunol Res 2015: 847985.
16) Ortona E, Colasanti T, Derme M, Iannini I, Vomero M, Sorice M, D’Alessandro F, Nanni Costa A, Malorni W, Orlando G, Framarino-dei-
Malatesta M. (2015) Serum antiphospholipid antibodies in transplanted patients: potential follow-up markers to assess pregnancy risk?
Transplantation 99: e152-154.
17) Misasi R, Capozzi A, Longo A, Recalchi S, Lococo E, Alessandri C, Conti C, Valesini G, Sorice M. (2015) “New” antigenic targets and
methodological approaches for refining laboratory diagnosis of antiphospholipid syndrome. J Immunol Res 2015: 858542.
18) Garofalo T, Manganelli V, Grasso M, Mattei V, Ferri A, Misasi R, Sorice M. (2015) Role of mitochondrial raft-like microdomains in the regulation
of cell apoptosis. Apoptosis 20: 621-634.
19) Barbati C, Alessandri C, Vomero M, Vona R, Colasanti T, Vacirca D, Camerini S, Crescenzi M, Pendolino M, Truglia S, Conti F, Garofalo T,
Sorice M, Pierdominici M, Valesini G, Malorni W, Ortona E. (2015) Autoantibodies specific to D4GDI modulate Rho GTPase mediated
cytoskeleton remodeling and induce autophagy in T lymphocytes. J Autoimmun 58: 78-89.
20) Conti F, Spinelli FR, Colafrancesco S, Truglia S, Ceccarelli F, Fattapposta F, Sorice M, Capozzi A, Ferretti G, Priori R, Martinelli F, Pirone C,
Alessandri C, Valesini G. (2015) Acute longitudinal myelitis following Cryptococcus laurentii pneumonia in a patient with systemic lupus
erythematosus. Lupus 24: 94-97.
21) Conti F, Capozzi A, Truglia S, Lcoco A, Longo A, Misasi R, Alessandri C, Valesini G, Sorice M. (2014) The mosaic of “seronegative“
antiphosholipid syndrome. J Immunol Res 2014: 389601.
22) Matarrese P, Garofalo T, Manganelli V, Gambardella L, Marconi M, Grasso M, Tinari A, Misasi R, Malorni W, Sorice M. (2014) Evidence for the
involvement of GD3 ganglioside in the autophagosome formation and maturation. Autophagy 10: 750-765.
23) Conti F, Alessandri C, Spinelli FR, Capozzi A, Martinelli F, Recalchi S, Misasi R, Valesini G, Sorice M. (2014) TLC immunostaining for
detection of “antiphospholipid” antibodies. Methods Mol Biol 1134: 95-101.
24) Conti F, Spinelli FR, Alessandri C, Pacelli M, Ceccarelli F, Marocchi E, Montali A, Capozzi A, Buttari B, Profumo E, Sorice M, Arca M, Valesini
G, Riganò R. (2014) Subclinical Atherosclerosis in systemic lupus erythematosus and antiphospholipid syndrome; focus on b2GPI-specific T
cell response. Arterioscler Thromb Vasc Biol 34: 661-668.
25) Marconi M, Ascione B, Ciarlo L, Gianni AM, Garofalo T, Sorice M, Locatelli SL, Stella CC, Malorni W, Matarrese P. (2013) Constitutive
localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies. Cell Death Dis Oct 17;4: e863.
26) Capozzi A, Vincentini O, Gizzi P, Porzia A, Longo A, Felli C, Mattei V, Mainiero F, Silano M, Sorice M, Misasi R. (2013) Modulatory effect of
gliadin peptide 10-mer on epithelial intestinal CACO-2 cell inflammatory response. PLoS One 8: e66561.
27) Delunardo F, Scalzi V, Capozzi A, Camerini S, Misasi R, Pierdominici M, Pendolino M, Crescenzi M, Sorice M, Valesini G, Ortona E,
Alessandri C. (2013) Streptococcal-vimentin cross-reactive antibodies induce microvascular cardiac endothelial proinflammatory phenotype in
Rheumatic Heart Disease. Clin Exp Immunol 173: 419-429.
28) Colasanti T, Alessandri C, Capozzi A, Sorice M, Delunardo F, Longo A, Pierdominici M, Conti F, Truglia S, Siracusano A, Valesini G, Ortona E,
Margutti P. (2012) Autoantibodies specific to a peptide of b2-glycoprotein I cross-react with TLR4 inducing a pro-inflammatory phenotype in
endothelial cells and monocytes. Blood 120: 3360-3370.
29) Sorice M, Mattei V, Tasciotti V, Manganelli V, Garofalo T, Misasi R. (2012) Trafficking of PrPc to mitochondrial raft-like microdomains during
cell apoptosis. Prion 6: 354-358.
30) Ciarlo L, Manganelli V, Matarrese P, Garofalo T, Tinari A, Gambardella L, Marconi M, Grasso M, Misasi R, Sorice M, Malorni W. (2012) Raftlike
microdomains play a key role in mitochondrial impairment in lymphoid cells from patients with Huntington’s disease. J Lipid Res 53: 2057-
31) Capozzi A, Lococo E, Grasso M, Longo A, Garofalo T, Misasi R, Sorice M. (2012) Detection of antiphospholipid antibodies by automated
chemiluminescence assay. J Immunol Methods 379: 48-52.
32) Conti F, Alessandri C, Sorice M, Capozzi A, Longo A, Garofalo T, Misasi R, Bompane D, Hughes GRV, Khamashta MA, Valesini G. (2012)
Thin-layer chromatography immunostaining in detecting anti-phospholipid antibodies in seronegative anti-phospholipid syndrome. Clin Exp
Immunol 167: 429-437.
33) Capozzi A, Mantuano E, Matarrese P, Saccomanni G, Manera C, Mattei V, Gambardella L, Malorni W, Sorice M, Misasi R. (2012) A new 4-
phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis. Anticancer
Agents Med Chem 12: 653-662.
34) Mattei V, Matarrese P, Garofalo T, Tinari A, Gambardella L, Ciarlo L, Manganelli V, Tasciotti V, Misasi R, Malorni W, Sorice M. (2011)
Recruitment of cellular prion protein to mitochondrial raft-like microdomains contributes to apoptosis execution. Mol Biol Cell 22: 4842-4853.
35) Buttari B, Profumo E, Capozzi A, Sorice M, Riganò R. (2011) Oxidized Human Beta2-Glycoprotein I: Its Impact on Innate Immune Cells.
Current Molecular Medicine 11: 719-725.
36) Sorice M, Garofalo T, Misasi R, Manganelli V, Vona R, Malorni W. (2012) Ganglioside GD3 as a raft component in cell death regulation. Anti
Cancer Agents in Medical Chemistry 12: 376-382.
37) Vacirca D, Delunardo F, Matarrese P, Colasanti T, Margutti P, Siracusano A, Pontecorvo S, Capozzi A, Sorice M, Francia A, Malorni W,
Ortona E. (2012) Autoantibodies to the adenosine triphosphate synthase play a pathogenetic role in Alzheimer’s disease. Neurobiol Aging 33:
38) Buttari B, Profumo E, Capozzi A, Facchiano F, Saso L, Sorice M, Riganò R. (2011) Advanced glycation end products of human
{beta}2glycoprotein I modulate the maturation and function of DCs. Blood 117: 6152-6161.
39) Manganelli V, Signore M, Pacini I, Misasi R, Tellan G, Garofalo T, Lococo E, Chirletti P, Sorice M, Delogu G. (2010) Increased HMGB1
expression and release by mononuclear cells following surgical/anestesia trauma. Crit Care 14: R197.
40) Khamashta MA, Hughes GRV, Ortona E, Capozzi A, Colasanti T, Conti F, Alessandri C, Longo A, Garofalo T, Margutti P, Misasi R, Valesini G,
Sorice M. (2010) Anti-vimentin/cardiolipin antibodies in “seronegative” Antiphospholipid syndrome. Blood Sep 17 [e-Letter].
41) Ortona E, Capozzi A, Colasanti T, Conti F, Alessandri C, Longo A, Garofalo T, Margutti P, Misasi R, Khamashta MA, Hughes GRV, Valesini G,
Sorice M. (2010) Vimentin/cardiolipin complex as a new antigenic target of the antiphospholipid syndrome. Blood 116: 2960-2967.
42) Ciarlo L, Manganelli V, Garofalo T, Matarrese P, Tinari A, Misasi R, Malorni W, Sorice M. (2010) Association of fission proteins with
mitochondrial raft-like domains. Cell Death Differ 17:1047-1058.
43) Sorice M, Matarrese P, Manganelli V, Tinari A, Giammarioli AM, Mattei V, Misasi R, Garofalo T, Malorni W. (2010) Role of GD3-CLIPR-59
association in lymphoblastoid T cell apoptosis triggered by CD95/Fas. PLoS One 5: e8567.
44) Delunardo F, Ortona E, Margutti P, Verdicchio M, Vacirca D, Teggi A, Sorice M, Siracusano A. (2010) Identification of a novel 19 kDa
Echinococcus granulosus antigen. Acta Trop 113: 42-47.
45) Sorice M, Manganelli V, Matarrese P, Tinari A, Misasi R, Malorni W, Garofalo T (2009) Cardiolipin-enriched raft-like microdomains are
essential activating platforms for apoptotic signals on mitochondria. FEBS Lett 583: 2447-2450.
46) Sorice M, Matarrese P, Tinari A, Giammarioli AM, Garofalo T, Manganelli V, Ciarlo L, Gambardella L, Maccari G, Botta M, Misasi R, Malorni W.
(2009) Raft component GD3 associates with tubulin following CD95/Fas ligation. FASEB J 23: 3298-3308.
47) Mattei V, Barenco MG, Tasciotti V, Garofalo T, Longo A, Boller K, Lower J, Misasi R, Montrasio F, Sorice M. (2009) Paracrine diffusion of PrPC
and propagation of prion infectivity by plasma membrane-derived microvesicles. PloS One 4: e5057.
48) Lopez Tresacasa M, Gil-Aguado A, Capozzi A, Sorice M. (2009) Association of anti-C1 inhibitor and anti-protein S antibodies in a patient with
primary anti-phospholipid syndrome. Lupus 18: 182-183.
49) Sorice M, Molinari S, Di Marzio L, Mattei V, Tasciotti V, Ciarlo L, Hiraiwa M, Garofalo T, Misasi R. (2008) Neurotrophic signalling pathway
triggered by prosaposin in PC12 cells occurs through lipid rafts. FEBS J 275: 4903-4912.
50) Malorni W, Garofalo T, Tinari A, Misasi R, Sorice M. (2008) Analyzing lipid rafts dynamics during cell apoptosis. Methods Enzymol 442: 125-
51) Matarrese P, Manganelli V, Garofalo T, Tinari A, Gambardella L, Ndebele K, Khosravi-Far R, Sorice M, Degli Esposti M, Malorni W. (2008)
Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type 2 cells. Biochem J 413: 467-478.
52) Margutti P, Matarrese P, Conti F, Colasanti F, Delunardo F, Capozzi A, Garofalo T, Profumo E, Riganò R, Siracusano A, Alessandri C, Salvati
B, Valesini G, Malorni W, Sorice M, Ortona E. (2008) Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and
endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis. Blood 111: 4559-4570.
53) Delunardo F, Margutti P, Pontecorvo S, Colasanti T, Conti F, Riganò R, Profumo E, Siracusano A, Capozzi A, Principe M, Sorice M, Francia,
Ortona E. (2007) Screening of microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer’s disease. J
Neuroimmunol 192: 105-112.
54) Margutti P, Delunardo F, Colasanti T, Piro E, Profumo E, Riganò R, Siracusano A, Buttari B, Conti F, Alessandri C, Capozzi A, Sorice M,
Ortona E. (2007) Screening of endothelial expression libraries for the identification of novel autoantigens involved in distinct autoimmune
diseases characterized by endothelial dysfunction. Ann NY Acad Sci USA 1109: 178-184.
55) Sorice M, Longo A, Capozzi A, Garofalo T, Misasi R, Alessandri C, Conti F, Buttari B, Riganò R, Ortona E, Valesini G. (2007) Anti-b2-GPI
antibodies induce monocyte release of TNFa and Tissue Factor by signal transduction pathways involving lipid rafts. Arthritis Rheum 56: 2687-
56) Garofalo T, Tinari A, Matarrese P, Giammarioli AM, Manganelli V, Ciarlo L, Misasi R, Sorice M, Malorni W. (2007) Do mitochondria act as
“cargo boats” in the journey of GD3 to the nucleus during apoptosis? FEBS Lett 581: 3899-3903.
57) Malorni W, Giammarioli A, Garofalo T, Sorice M. (2007) Dynamics of lipid raft components during lymphocyte apoptosis: the paradigmatic role
of GD3. Apoptosis 12: 941-949.
58) Tinari A, Garofalo T, Sorice M, Esposti MD, Malorni W. (2007) Mitoptosis: different pathways for mitochondrial execution. Autophagy 3: 282-
59) Riganò R, Buttari B, Profumo E, Ortona E, Delunardo F, Margutti P, Mattei V, Teggi A, Sorice M, Siracusano A. (2007) Echinococcus
Granulosus Antigen B Impairs Human Dendritic Cell Differentiation and Polarizes Immature Dendritic Cell Maturation towards a Th2 Cell
Response. Infect Immunity 75: 1667-1678.
60) Barbat C, Trucy M, Sorice M, Garofalo T, Manganelli V, Fischer A, Mazerolles F (2007) p56lck, LFA-1 and PI3K but not SHP-2 interact with
GM1- or GM3-enriched microdomains in a CD4/p56lck association-dependent manner. Biochem J 402: 471-481.
61) Alessandri C, Sorice M, Bombardieri M, Conigliaro P, Longo A, Garofalo T, Manganelli V, Conti F, Degli Esposti M, Valesini G. (2006)
Antiphospholipid reactivity against cardiolipin metabolites occurring during endothelial cell apoptosis. Arthritis Res Therapy. 8: R180-190.
62) Ouasti S, Matarrese P, Paddon R, Khosravi-Far R, Sorice M, Tinari A, Malorni W, Degli Esposti M. (2007) Death receptor ligation triggers
membrane scrambling between Golgi and mitochondria. Cell Death Differ 14: 453-461.
63) Delunardo F, Conti F, Margutti P, Alessandri C, Priori R, Siracusano A, Riganò R, Profumo E, Valesini G, Sorice M, Ortona E. (2006)
Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behcet's disease. Arthritis Res Therapy 8:
64) Sottocornola E, Misasi R, Mattei V, Ciarlo L, Gradini R, Garofalo T, Berra B, Colombo I, Sorice M. (2006) Role of gangliosides in the
association of ErbB2 with lipid rafts in mammary epithelial HC11 cells. FEBS J 273: 1821-1830.
65) Aceti A, Zechini B, Griggi T, Marangi M, Pasquazzi C, Quaranta G, Sorice M. (2005) Undetectable phospho-STAT1 in peripheral blood
mononuclear cells from patients with chronic hepatitis C who do not respond to interferon-a therapy. Liver Int 25: 987-993.
66) Sirinian MI, Belleudi F, Campagna F, Ceridono M, Garofalo Quagliarini TF, R. Verna, S. Calandra, S. Bertolini, M. Sorice, M.R. Torrisi, M. Arca
(2005) Adaptor protein ARH is recruited to the plasma membrane by LDL binding and modulates endocytosis of the LDL/LDLR complex in
hepatocytes. J Biol Chem 280: 38416-38423.
67) Buttari B, Profumo E, Mattei V, Siracusano A, Ortona E, Margutti P, Salvati B, Sorice M, Riganò R (2005) Oxidized (beta)2-glycoprotein I
induces human dentritic cell maturation and promotes a T helper type I response. Blood 106: 3880-3887.
68) Garofalo T, Giammarioli AM, Misasi R, Tinari A, Manganelli V, Gambardella L, Pavan A, Malorni W, Sorice M. (2005) Lipid microdomains
contribute to apoptosis-associated modifications of mitochondria in T cells. Cell Death Differ 12: 1378-1389.
69) Margutti P, Sorice M, Conti, F Delunardo F, Racaniello M, Alessandri C, Siracusano A, Riganò R, Profumo E, Valesini G, Ortona E. (2005)
Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with
psychiatric manifestations. Arthritis Res Therapy 7: R896-R903.
70) Alessandri C, Bombardieri M, Di Prospero L, Conigliaro P, Conti F, Labbadia G, Misasi R, Sorice M, Valesini G. (2005) Antilysobisphosphatidic
acid antibodies in patients with antiphospholipid syndrome and systemic lupus erythematosus. Clin Exp Immunol 140: 173-
71) Trucy M, Barbat C, Sorice M, Fischer A, Mazerolles F. (2004) CD4-induced down regulation of T cell adhesion to B cells is associated with
localization of phosphatidyl inositol 3-kinase and LFA-1 in distinct membrane domains. Eur J Immunol 34: 2168-2178.
72) Misasi R, Garofalo T, Di Marzo L, Mattei V, Gizzi C, Hiraiwa M, Pavan A, Cifone MG, Sorice M. (2004) Prosaposin: a new player in cell death
prevention of U937 monocytic cells. Exp Cell Res 298: 38-47.
73) Margutti P, Delunardo F, Sorice M, Valesini G, Alessandri C, Captano R, Profumo E, Siracusano A, Salvati B, Riganò R, Ortona E. (2004)
Screening of a HUAEC cDNA library identifies actin as a candidate autoantigen associated with carotid atherosclerosis. Clin Exp Immunol 137:
74) Sorice M, Circella A, Cristea IM, Garofalo T, Di Renzo L, Alessandri C, Valesini G, Degli Esposti M. (2004) Cardiolipin and its metabolites
move from mitochondria to other cellular membranes during death receptor-mediated apoptosis. Cell Death Differ 11: 1133-1145.
75) Scaccianoce S, Mattei V, Del Bianco P, Gizzi C, Sorice M, Hiraiwa M, Misasi R. (2004) Hippocampal prosaposin changes during stress: a
glucocorticoid independent event. Hippocampus 14: 275-280.
76) Mattei V, Garofalo T, Misasi R, Circella A, Manganelli V, Lucania G, Pavan A, Sorice M. (2004) Prion protein is a component of the
multimolecular signaling complex involved in T cell activation. FEBS Lett 560: 14-18.
77) Sorice M, Longo A, Garofano T, Mattei V, Misasi R, Pavan A. (2004) Role of GM3 enriched microdomains in signal transduction regulation in T
lymphocytes. Glycocon J 20: 63-70.
78) Pittoni V, Sorice M, Circella A, Cangemi R, Conti L, Ramenghi U, Gandolfi GM, Dianziani U, Valesini G. (2003). Specificity of antinuclear and
antiphospholipid antibodies in sera of patients with autoimmune lymphoproliferative disease (ALD). Clin Exp Rheumatol 21: 377-385.
79) Conti F, Sorice M, Circella A, Alessandri C, Pittoni V, Caronti B, Calderaio C, Griggi T, Misasi R, Valesini G. (2003) Beta-2-glycoprotein I
expression on monocytes is increased in anti-phospholipid antibody syndrome and correlates with Tissue Factor expression. Clin Exp Immunol
132: 509-516.
80) Garofalo T, Misasi R, Mattei V, Giammarioli AM, Malorni W, Pontieri GM, Pavan A, Sorice M. (2003) Association of the death-inducing
signaling complex with microdomains after triggering through CD95/Fas. Evidence for caspase-8-ganglioside interaction in T cells. J Biol Chem
278: 8309-8315.
81) Mattei V, Garofalo T, Misasi R, Gizzi C, Mascellino MT, Pontieri GM, Sorice M, Pavan A. (2002) Association of cellular prion protein with
gangliosides in microdomains of neural and lymphocytic cells. Neurochem Res 27: 743-749.
82) Garofalo T, Sorice M, Misasi R, Cinque B, Mattei V, Pontieri GM, Cifone MG, Pavan A. (2002) Ganglioside GM3 activates ERKs in human
lymphocytic cells. J Lipid Res 43: 971-978.
83) Garofalo T, Lenti L, Longo A, Misasi R, Mattei V, Pontieri GM, Pavan A, Sorice M. (2002) Association of GM3 with Zap-70 induced by T cell
activation in plasma membrane microdomains. GM3 as a marker of microdomains in human lymphocytes. J Biol Chem 277: 11233-11238.
84) Sorice M, Ferro D, Misasi R, Pittoni V, Longo A, Circella A, Garofalo T, Gradini R, Violi F, Gruenberg J, Valesini G. (2002) Evidence for
anticoagulant activity and b2-GPI accumulation in late endosomes of endothelial cells induced by anti-LBPA antibodies. Thromb Haemost 87:
85) Sorice M, Garofalo T, Misasi R, Longo A, Mattei V, Sale P, Dolo V, Gradini R, Pavan A. (2001) Evidence for cell surface association between
CXCR4 and ganglioside GM3 after gp120 binding in Sup T1 lymphoblastoid cells. FEBS Lett 506: 55-60.
86) Giammarioli AM, Garofalo T, Sorice M, Misasi R, Gambardella L, Gradini R, Fais S, Pavan A, Malorni W. (2001) GD3 glycosphingolipid
contributes to Fas mediated apoptosis via association with ezrin cytoskeletan protein. FEBS Lett 506: 45-50.
87) Misasi R, Sorice M, Di Marzo L, Campana WM, Molinari S, Cifone MG, Pavan A, Pontieri GM, O’Brien JS. (2001) Prosaposin Treatment
Induces PC12 Entry in the S phase of the Cell Cycle and Prevents Apoptosis: Activation of ERK’s and Sphingosine Kinase. FASEB J 15: 267-
88) Sorice M, Circella A, Misasi R, Pittoni V, Garofalo T, Girelli A, Pavan A, Pontieri GM, Valesini G. (2000) Cardiolipin on the surface of apoptotic
cells as a possible trigger for antiphospholipid antibodies. Clin Exp Immunol 122: 277-284.
89) Dolo V, D’Ascenzo S, Sorice M, Pavan A, Sciannamblo MT, Prinetti A, Chigorno V, Tettamanti G, Sonnino S. (2000) New approaches to the
study of sphingolipid enriched membrane domains: the use of electron microscopic autoradiography to reveal metabolically tritium labeled
sphingolipids in cell cultures. Glycoconjugate J 17: 261-268.
90) Sorice M, Garofalo T, Misasi R, Longo A, Mikulak J, Dolo V, Pontieri GM, Pavan A. (2000) Association between GM3 and CD4-lck complex in
human peripheral blood lymphocytes. Glycoconjugate J 17: 247-252.
91) Misasi R, Sorice M, Garofalo T, Griggi T, Giammarioli AM, d’Ettorre G, Vullo V, Pontieri GM, Malorni W, Pavan A. (2000) Overexpression of
lymphocytic GD3 ganglioside and presence of anti-GD3 antibodies in patients with HIV infection. AIDS Res Hum Retrov 16: 1539-1549.
92) Sorice M, Pittoni V, Griggi T, Losardo A, Leri O, Magno MS, Misasi R, Valesini G. (2000) Specificity of antiphospholipid antibodies in infectious
mononucleosis: a role for anti-cofactor protein antibodies. Clin Exp Immunol 120: 301-306.
93) Visco V, Lucania G, Sansolini T, Dolo V, Garofalo T, Sorice M, Frati L, Torrisi MR, Pavan A. (2000) Expression of GM3 microdomains on the
surfaces of murine fibroblasts correlates with inhibition of cell proliferation. Histochem Cell Biol 113: 43-50.
94) Priori R, Conti F, Pittoni V, Garofalo T, Sorice M, Valesini G. (2000) Is there a role for antiphospholipid-binding protein antibodies in the
pathogenesis of thrombosis in Behçet’s disease? Thromb Haemost 83: 173-174.
95) Sorice M, Garofalo T, Misasi R, Dolo V, Lucania G, Sansolini T, Parolini I, Sargiacomo M, Torrisi MR, Pavan A. (1999) Glycosphingolipid
domains on cell plasma membrane. Bioscience Rep 19: 197-208.
96) Bordi F, Cametti C, DeLuca F, Naglieri A, Misasi R, Sorice M. (1999) Interactions of mono- and di-sialogangliosides with phospholipids in
mixed monolayers at air-water interface. Colloids & Surfaces B 13: 135-142.
97) De Luca F, Bordi F, Cametti C, Naglieri A, Misasi R, Sorice M. (1999) Cluster Organization of Glycosphingolipid GD1a in Lipid Bilayer
Membranes. A Dielectric and Conductometric Study. Langmuir 15: 2493-2499.
98) Parolini I, Topa S, Sorice M, Pace A, Ceddia P, Montesoro E, Pavan A, Lisanti MP, Peschle C, Sargiacomo M. (1999) Phorbol-ester-induced
disruption of the CD4/lck complex occurs within a detergent-resistant microdomain of the plasma membrane. Involvement of the translocation
of activated PKC isoforms. J Biol Chem 274: 14176-14187.
99) Misasi R, Sorice M, Garofalo T, Griggi T, Campana WM, Giammatteo M, Pavan A, Hiraiwa M, Pontieri GM, O'Brien JS. (1998) Colocalization
and Complex Formation Between Prosaposin and Monosialoganglioside GM3 in Neural Cells. J Neurochem 71: 2313-2321.
100) Garofalo T, Sorice M, Misasi R, Cinque B, Giammatteo M, Pontieri GM, Cifone MG, Pavan A. (1998) A novel mechanism of CD4 downmodulaton
induced by monosialoganglioside GM3: involvement of serine phosphorylation and protein kinase C d translocation. J Biol Chem
273: 35153-35160.
101) Sorice M, Pittoni V, Circella A, Misasi R, Conti F, Longo A, Pontieri GM, Valesini G. (1998) Anti-prothrombin but not "pure" Anti-cardiolipin
Antibodies are Associated with the Clinical Features of the Antiphospholipid Antibody Syndrome. Thromb Haemost 80: 713-715.
102) Marchese C, Sorice M, Finch PW, Frati L, Torrisi MR. (1997) Modulation of Keratinocyte Growth Factor Receptor Expression in Human
Cultured Keratinocytes. Cell Growth Differentiation 8: 989-997.
103) Sorice M, Parolini I, Sansolini T, Garofalo T, Sargiacomo M, Tai T, Peschle C, Torrisi MR, Pavan A. (1997) Evidence for the Existence of
Ganglioside Enriched Plasma Membrane Domains in Human Peripheral Lymphocytes. J Lipid Res 38: 969-980.
104) Cametti C, De Luca F, Macrì MA, Maraviglia B, Misasi R, Sorice M, Pavan A, Garofalo T, Pontieri GM, Bordi F, Zimatore G (1996) Influence of
different glycosphingolipids on the conductometric properties of a model phospholipid membrane system. Collloids & Surfaces B 7: 39-46.
105) Sorice M, Garofalo T, Sansolini T, Griggi T, Circella A, Massetti A, Tai T, Pavan A (1996) Overexpression of monosialoganglioside GM3 on
lymphocyte plasma membrane in patients with HIV infection. J AIDS 12: 112-119.
106) Muller C, Szangolies M, Kukel S, Kiehl M, Sorice M, Griggi T, Lenti L, Bauer R (1996) Characterization of autoantibodies to natural killer cells
in HIV-infected patients. Scand. J. Immunol. 43: 583-592.
107) Misasi R, Sorice M, Carson GS, Griggi T, Lenti L, Pontieri GM, O'Brien JS (1996) Prosaposin and prosaptide, a peptide from prosaposin,
induce an increase of ganglioside content on NS20Y neuroblastoma cells. Glycoconjugate J 13: 195-202.
108) Sorice M, Arcieri P, Griggi T, Circella A, Misasi R, Lenti L, Di Nucci GD, Mariani G (1996) Inhibition of protein S by autoantibodies in patients
with acquired protein S deficiency. Thromb Haemost 75: 555-559.
109) Sorice M, Griggi T, Nicodemo G, Garofalo T, Marangi M, Sanguigni S, Becker SI, Mirelman D (1996) Evidence for the existence of ganglioside
molecules in the antigen of Entamoeba histolytica. Parasite Immunol. 18: 133-137.
110) Sorice M, Circella A, Griggi T, Garofalo T, Nicodemo G, Pittoni V, Pontieri GM, Lenti L, Valesini G. (1996) Anticardiolipin and Anti-b2GPI are
Two Distinct Populations of Autoantibodies. Thromb Haemost. 75: 303-308.
111) Sorice M, Griggi T, Circella A, Nicodemo G, Ciardi M, Mastroianni CM, Lenti L, Sorice F. (1995) Cerebrospinal fluid antiganglioside antibodies
in patients with AIDS. Infection 23: 288-291.
112) Sorice M, Pavan A, Misasi R, Sansolini T, Garofalo T, Lenti L, Pontieri GM, Frati L, Torrisi MR. (1995) Monosialoganglioside GM3 induces
CD4 internalization in human peripheral blood T lymphocytes. Scand J Immunol. 41: 148-156.
113) Cametti C, De Luca F, Macrì MA, Maraviglia B, Zimatore G, Bordi F, Misasi R, Sorice M, Lenti L, Pavan A (1995) To what extent are the
passive electrical parameters of lymphocyte membranes deduced from impedance spectroscopy altered by surface roughness and
microvillosity? Colloids & Surfaces B 3: 309-316.
114) Lafeuillade A, Sorice M, Griggi T, Pellegrino P, Geoffroy M, Profizi N. (1994) Role of autoimmunity in protein S deficiency during HIV-1
infection. Infection 22: 201-203.
115) Sorice M, Griggi T, Circella A, Garofalo T, d'Agostino F, Pittoni V, Pontieri GM, Lenti L, Valesini G. (1994) Detection of antiphospholipid
antibodies by immunostaining on thin layer chromatography plates. J Immunol Methods 173: 49-54.
116) Griggi T, Bauer R, Garofalo T, Kukel S, Lenti L, Massetti AP, Muller C, Sorice M, Pontieri GM. (1994) Autoantibodies against ganglioside GM3
represent a portion of antilymphocyte antibodies in AIDS patients. Scand. J. Immunol. 40: 77-82.
117) Sorice M, Griggi T, Circella A, Lenti L, Arcieri P, Di Nucci G, Mariani G. (1994) Protein S antibodies in acquired protein S deficiencies. Blood
83: 2383-2384.
118) Sorice M, Griggi T, Arcieri P, Circella A, d'Agostino F, Ranieri M, Modrewska R, Lenti L, Mariani G. (1994) Protein S and HIV infection. The
role of anticardiolipin and anti-protein S antibodies. Thromb Res 73: 165-175.
119) Lafeuillade A, Sorice M, Griggi T, Pellegrino P, Geoffroy M, Profizi N, Quilichini R. (1993) Role de l’autoimmunité dans le déficit en protéine S
au cours de l’infection à VIH. Rev Med Interne 14: 1092.
120) Cametti C, De Luca F, Macrì MA, Maraviglia B, Misasi R, Sorice M. (1993) Influence of GM3 and GD3 glycolipids on the conductometric
properties of a model membrane system. Coll Polym Sci 93: 188-190.
121) Cametti C, De Luca F, Macrì MA, Maraviglia B, Misasi R, Sorice M. (1993) Radio-frequency dielectric spectroscopy of synthetic bilayers
containing glycolipids. Colloids & Surfaces A 72: 173-176.
122) Misasi R, Sorice M, Griggi T, d'Agostino F, Garofano T, Masala C, Pontieri GM, Lenti L. (1993) GM3 as a target of anti-lymphocytic
ganglioside antibodies in AIDS patients. Clin Immunol Immunopathol 67: 216-223.
123) Cametti C, De Luca F, D'Ilario A, Macrì MA, Maraviglia B, Bordi F, Lenti L, Misasi R, Sorice M. (1992) Alteration of the passive electrical
properties of lymphocyte membranes induced by GM1 and GM3 glycolipids. Biochim. Biophys. Acta 1111: 197-203.
124) Aceti A, Taliani G, Sorice M, Amendolea MA. (1992) HCV and Sjogren's syndrome. Lancet 339: 1425-1426.
125) Cametti C, De Luca F, D'Ilario A, Maraviglia B, Misasi R, Sorice M, Bordi F, Macrì MA. (1992) Structural alteration of lymphocyte membrane
induced by gangliosides. A conductometric study. Coll Polym Sci 89: 319-323.
126) Sorice M, Lenti L, Misasi R, Contini C, Cignarella L, Griggi T, Vullo V, Masala C. (1992) Evidence for the existence of ganglioside molecules
on Pneumocystis carinii from human lungs. Parasitology 105: 1-6.
127) Sorice M, Lenti L, Misasi R, Di Prima MA, Griggi T, Cignarella L, Vullo V, Masala C. (1991) Anti-glycosphingolipid antibodies in HIV infection.
AIDS 5: 345-346.
128) Masala C, Sorice M, Di Prima MA, Lenti L, Misasi R, Mojon M, Contini C, Vullo V. (1989) Evidence for shared epitopes between cardiolipin
and Pneumocystis carinii. J Infect Dis 160: 736-737.
129) Masala C, Sorice M, Di Prima MA, Lenti L, Misasi R, Contini C, Vullo V. (1989) Anticardiolipin antibodies and Pneumocystis carinii pneumonia
Ann Intern Med 110: 749.
130) Di Prima MA, Sorice M, Vullo V, Mastroianni CM, Amendolea MA, Masala C. (1989) Anticardiolipin antibody in the acquired immunodeficiency
syndrome: a marker of Pneumocystis carinii infection? J Infect 18: 100-101.